{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T02:11:46Z","timestamp":1785809506555,"version":"3.56.0"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"13","license":[{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100020638","name":"Allergan Aesthetics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020638","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Aesth Plast Surg"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Chinese individuals may seek chin enhancement to address esthetic perceptions regarding chin retrusion. Because studies of the injectable hyaluronic acid gel VYC-25L (Allergan Aesthetics, an AbbVie Company, Irvine, CA) contained few Asian subjects and none from China, its effects on chin retrusion in Chinese individuals are unclear. This 12-month, real-world evidence study evaluated the safety and effectiveness of VYC-25L for chin enhancement in Chinese adults.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>At Hainan Bo\u2019ao Super Hospital, 2 cohorts of prospectively and retrospectively enrolled adults received VYC-25L treatment (maximum 4 mL). Cohort 1 only underwent 3D imaging before and after treatment for digital analysis. The primary effectiveness measure was mean change from baseline in glabella\u2013subnasale\u2013pogonion (G\u2013Sn\u2013Pog) angle at month 3 based on 3D facial images. Both cohorts completed the Global Aesthetic Improvement Scale (GAIS; subjects and investigators) and a satisfaction questionnaire (subjects). Injection site response (ISR) and adverse events were recorded.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Of 90 subjects enrolled (cohort 1, n=36; cohort 2, n=54), 89 completed the study. Mean change from baseline in G\u2013Sn\u2013Pog angle at month 3 was 3.19 degrees (95% CI, 2.55\u20133.83; <jats:italic>P<\/jats:italic> &lt; 0.001 vs 0), with improvement maintained through 12 months. Month 3 \u201cimproved\u201d\/\u201cmuch improved\u201d GAIS responder frequencies were 94.3% (investigators) and 97.1% (subjects); 91.5% of subjects were \u201csatisfied\u201d\/\u201cvery satisfied\u201d with treatment at month 3. Most (&gt;70%) ISRs were mild or moderate in severity. Four treatment-related adverse events occurred (all mild).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>VYC-25L was safe and effective for enhancement of the chin and jaw in Chinese adults.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Level of Evidence III<\/jats:title>\n            <jats:p>This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.springer.com\/00266\" ext-link-type=\"uri\">www.springer.com\/00266<\/jats:ext-link>.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00266-024-04572-3","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T12:11:06Z","timestamp":1740571866000},"page":"3545-3553","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Hyaluronic Acid Injectable Gel VYC-25L Is Safe and Effective for Adults Seeking Chin Enhancement to Correct Chin Retrusion: Results From a Real-world Evidence Study in China"],"prefix":"10.1007","volume":"49","author":[{"given":"Yimin","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danru","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingfeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smita","family":"Chawla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,26]]},"reference":[{"issue":"1","key":"4572_CR1","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.cps.2015.09.021","volume":"43","author":"JM Sykes","year":"2016","unstructured":"Sykes JM, Su\u00e1rez GA (2016) Chin advancement, augmentation, and reduction as adjuncts to rhinoplasty. 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Grace Zhao and Smita Chawla are full-time employees of AbbVie\u00a0and may own AbbVie stock. This study was approved by an independent ethics committee and was conducted in compliance with the Declaration of Helsinki and applicable laws and regulations, including the China Medical Device Good Clinical Practice guidelines. All subjects provided written informed consent prior to any data collection.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}