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Compared with the control group, the TXA group showed a mean reduction in intraoperative blood loss of 171.30 ml (p &lt; 0.00001; 95% CI, 197.58-145.02 ml). Systemic tranexamic acid use was associated with reduced operative time by a mean of14.5 minutes (p &lt; 0.0001; 95% CI, 20.89-8.02 mins) and reduction in the need for transfusion OR= 0.33 (p &lt; 0.01; 95% CI, 0.14-0.77).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>This systematic review and meta-analysis supports the prophylactic use of tranexamic acid during orthognathic surgery in reducing blood loss, operative time and the risk of needing blood transfusions without increasing risk of thromboembolic complications.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Level of Evidence I<\/jats:title>\n            <jats:p>This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to Table of Contents or the online Instructions to Authors \u00a0<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.springer.com\/00266\" ext-link-type=\"uri\">www.springer.com\/00266<\/jats:ext-link>.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00266-025-04738-7","type":"journal-article","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T18:43:12Z","timestamp":1741632192000},"page":"2932-2946","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Prophylactic Tranexamic Acid Use in Orthognathic Surgery: A Systematic Review and Meta-analysis"],"prefix":"10.1007","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2197-0519","authenticated-orcid":false,"given":"Hooman","family":"Baghaie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khilan","family":"Shukla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Stone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Breik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary","family":"Munn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,10]]},"reference":[{"issue":"1","key":"4738_CR1","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1001\/jamaoto.2015.2678","volume":"142","author":"S Zaghi","year":"2016","unstructured":"Zaghi S, Holty J-EC, Certal V, et al. 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