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Vulvar scarring is\u00a0the most common long-term effect associated with FGM, representing one of the main unmet issues in FGM women\u2019s health. Regenerative therapies based on the use of adipose-derived stem cells are considered the standard of care for ameliorating scarring and fibrosis. This study aimed to explore the potential of fat grafting in the treatment of post-FGM vulvar scars.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirteen FGM survivors with vulvar scars underwent autologous fat grafting and were assessed using the Vulvar architecture severity scale (VASS), Female genital self-image scale (FGSIS), Female sexual function index (FSFI), and Hospital anxiety and depression scale (HADS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At an average follow-up of 12.23 months (\u00b1\u20093.03), clinical results (VASS) showed a significant improvement in all vulvar aesthetic units treated with FG (\n                      <jats:italic>p\u2009<\/jats:italic>\n                      &lt;\u20090.001). Patients reported improvements in genital-related self-image (FGSIS) (\n                      <jats:italic>p\u2009<\/jats:italic>\n                      =\u20090.001), sexual function (FSFI) (\n                      <jats:italic>p\u2009<\/jats:italic>\n                      =\u20090.019), and psychological well-being (HADS) (\n                      <jats:italic>p\u2009<\/jats:italic>\n                      =\u20090.002).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Fat grafting ameliorates FGM-related vulvar scars and improves volumetric contouring of vulvar aesthetic units, with a positive effect on women\u2019s quality of life. This minimally invasive intervention has far-reaching implications, providing a cost-effective solution accessible even in low-resource settings to potentially improve the overall well-being of millions of women living worldwide with a form of FGM. The results of this study warrant further testing in future clinical trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence IV<\/jats:title>\n                    <jats:p>\n                      This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.springer.com\/00266\" ext-link-type=\"uri\">www.springer.com\/00266<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00266-025-04895-9","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T10:59:45Z","timestamp":1747997985000},"page":"6954-6966","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Novel Approach to Female Genital Mutilation Reconstruction with Fat Grafting and Adipose Stem Cell Therapies: A Minimally Invasive Solution with a Potential Impact on Millions of Women Worldwide"],"prefix":"10.1007","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8783-3192","authenticated-orcid":false,"given":"Aurora","family":"Almadori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Butler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzia","family":"Salgarello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,23]]},"reference":[{"key":"4895_CR1","volume-title":"Female genital mutilation\/cutting: A statistical overview and exploration of the dynamics of change","author":"United Nations Children\u2019s Fund","year":"2013","unstructured":"United Nations Children\u2019s Fund. 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