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The patients were divided into two groups: one receiving botulinum toxin micro-droplet injection combined with micro-crosslinked hyaluronic acid sodium gel (\n                      <jats:italic>n<\/jats:italic>\n                      =56) and the other receiving botulinum toxin micro-droplet injection combined with focused ultrasound technology (\n                      <jats:italic>n<\/jats:italic>\n                      =58). The study assessed baseline characteristics, procedural aspects, recovery, side effects, facial laxity and rejuvenation (FLR), and quality of life using validated rating scales and criteria.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study revealed several significant findings. The procedural duration was shorter in the micro-crosslinked sodium hyaluronate gel group, whereas the time to return to normal activities was shorter in the focused ultrasound group. The incidence of edema and erythema was significantly lower in the focused ultrasound group. FLR scale scores showed better skin elasticity and tightness in the focused ultrasound group, while quality of life scores indicated variations in emotion management and return to social function between the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The study emphasizes the multifaceted impact of botulinum toxin micro-droplet injection combined with micro-crosslinked sodium hyaluronate gel and focused ultrasound technology on various parameters in facial rejuvenation treatment. These findings provide valuable insights into the differential effects of these treatment modalities, highlighting the need for personalized approaches and patient-centered care in cosmetic dermatology and plastic surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence II<\/jats:title>\n                    <jats:p>\n                      This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to\u00a0Authors \u00a0\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.springer.com\/00266\" ext-link-type=\"uri\">www.springer.com\/00266<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00266-025-04903-y","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T10:52:50Z","timestamp":1749034370000},"page":"5284-5291","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Comparative Study of the Effects of Botulinum Toxin Micro-droplet Injection Combined with Micro-crosslinked Sodium Hyaluronate Gel or Focused Ultrasound Technology in Facial Rejuvenation Treatment"],"prefix":"10.1007","volume":"49","author":[{"given":"Yanan","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yerong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4385-3595","authenticated-orcid":false,"given":"Demei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,4]]},"reference":[{"key":"4903_CR1","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1159\/000354083","volume":"65","author":"MC De Vos","year":"2013","unstructured":"De Vos MC, Van den Brande H, Boone B, Van Borsel J. 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