{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T13:03:25Z","timestamp":1780059805690,"version":"3.54.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"19","license":[{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Xcodes Co., LTD.","award":["109426CJ"],"award-info":[{"award-number":["109426CJ"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Aesth Plast Surg"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Supraperiosteal injection by calcium hydroxyapatite (CaHA) fillers is an efficient treatment for facial rejuvenation to achieve bony recontouring, facial augmentation and lifting. However, a safe and efficient injection technique for Asians was not described, and an assessment scale to quantify \u201cfacial anti-aging\u201d does not exist.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We enrolled 16 Asian women (\n                      <jats:italic>n<\/jats:italic>\n                      = 32) to receive a single session of six-point calcium hydroxyapatite (CaHA, Radiesse\u00ae Plus) filler injections between July 1, 2021, and July 1, 2022. The six injection sites included the eyebrow arch, lateral eyebrow, lateral zygoma, piriform fossa, lateral chin, and anteromedial cheek. Efficacy was assessed at weeks 0 (immediately post-treatment), 4, 12, and 24 using a specialized angular and length measurement system, with outcomes further evaluated using an 11-level anti-aging scale.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the four angular and six linear parameters assessed, statistically significant variations were observed across five time points. Regarding post hoc analyses, the Eyebrow-Tail angle showed a statistically significant change at week 24, increasing by 2.84\u00b0 (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001) and corresponding to an anti-aging scale value of 6. This parameter indicated eyebrow lifting. The Tragus-Oral (\u221210.4 mm,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.004) and Lower Facial Contouring (\u22129.8 mm,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.044) showed statistically significant reductions and received aging scale ratings of 10 and 9, respectively, at week 24. These two parameters indicated achieving jawline refining. Overall, the final anti-aging scale improved from an average of 50\u201359, with minimal or ignorable ecchymosis and swelling at week 24.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The 6-point calcium hydroxyapatite filler injection achieved facial rejuvenation. After a single session, the injection recontoured the jawline and lifted the eyebrow tail.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence IV<\/jats:title>\n                    <jats:p>\n                      This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine Ratings, please refer to Table of Contents or online Instructions to Authors\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.springer.com\/00266\" ext-link-type=\"uri\">www.springer.com\/00266<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00266-025-05045-x","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T15:08:15Z","timestamp":1751555295000},"page":"5316-5324","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Novel Six-Point Supraperiosteum Injection with Calcium Hydroxyapatite for Jawline Refining and Facial Anti-aging in Asian Patients"],"prefix":"10.1007","volume":"49","author":[{"given":"Bing-Qi","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Jhen","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0463-7346","authenticated-orcid":false,"given":"Chang-Cheng","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man-Lok","family":"Lio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Chun","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiu-Mei","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung-Hsueh","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Chuan","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,3]]},"reference":[{"key":"5045_CR1","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1093\/asj\/sjaa339","volume":"41","author":"A Swift","year":"2021","unstructured":"Swift A, Liew S, Weinkle S, Garcia JK, Silberberg MB. 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(Grant No.109426CJ). Other authors declare that they have no conflict of interest to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The research was approved by the institutional review board of China Medical University Hospital in Taichung (CMUH109-REC1-137).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"All authors listed have made a substantial, direct, and intellectual contribution to the work, and gave final approval of the version to be published.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}}]}}