{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:26:04Z","timestamp":1790742364355,"version":"4.1.0"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100007642","name":"Universit\u00e0 degli Studi di Roma Tor Vergata","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007642","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Aesth Plast Surg"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The author presents his own experience using breast implants (BIs) or fat grafting, commonly called lipofilling (LPF), to correct breast hypoplasia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Compare the aesthetic results obtained in a study group (SG) using BIs in breast hypoplasia correction with those of a control group (CG) treated with LPF, analyzing the influence of breast and chest deformities (tuberous breast, breast volume differences\/asymmetries, nipple\u2013areola complex asymmetry, pectus excavatum, and carinatum) in the outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A randomized, open-label controlled study was performed. A total of 95 patients affected by breast hypoplasia (SG) were treated with BI, comparing results with the CG (n = 90) treated with LPF. The pre-operative analysis was conducted through anamnesis (considering also the patient\u2019s expectations), clinical and photographic assessment, and an instrumental evaluation based on magnetic resonance imaging, mammography, and ultrasound. Post-operative follow-up occurred at 1, 2, 4 weeks, 3, 6, 12 months, and then annually until the fourth year.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      87,5% (n = 83) of SG patients treated with BI showed excellent aesthetic outcomes after 12 months compared with the CG patients treated with LPF, who showed the same results in 70% (n = 63) of cases. Breast augmentation maintenance in the SG was significantly higher than in the CG (\n                      <jats:italic>p\u2009<\/jats:italic>\n                      &lt;\u2009.0001). However, more natural results were reported in the CG than in the SG (\n                      <jats:italic>p\u2009<\/jats:italic>\n                      &lt;\u2009.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>BI and LPF were safe and effective in this controlled trial. CG's patients displayed more natural results, obtaining a better pectus excavatum correction, while SG\u2019s patients showed more evident and lasting results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence I<\/jats:title>\n                    <jats:p>\n                      This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.springer.com\/00266\" ext-link-type=\"uri\">www.springer.com\/00266<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00266-025-05204-0","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T17:03:44Z","timestamp":1757005424000},"page":"1044-1056","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Breast Implants or Lipofilling in Augmentation Mammoplasty? A Randomized, Open-Label, Controlled Trial"],"prefix":"10.1007","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3123-3977","authenticated-orcid":false,"given":"Pietro","family":"Gentile","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,4]]},"reference":[{"issue":"3","key":"5204_CR1","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1093\/asj\/sjv181","volume":"36","author":"Y Bayram","year":"2016","unstructured":"Bayram Y, Zor F, Karagoz H, et al. Challenging breast augmentations: the influence of preoperative anatomical features on the final result. Aesthet Surg J. 2016;36(3):313\u201320.","journal-title":"Aesthet Surg J"},{"issue":"9","key":"5204_CR2","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1093\/asj\/sjz292","volume":"40","author":"P Gentile","year":"2020","unstructured":"Gentile P, Kothari A, Casella D, et al. 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The investigation protocol was developed in agreement with an associate professor contract #13489\/2021 between the author and the University of Tor Vergata, Rome, Italy, and as a part of a research project approved by the Surgical Science Department with number: E83C22001960005.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"All procedures performed were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and Animal Rights"}},{"value":"All participants gave their informed consent in writing before inclusion in the study. In detail, all patients received detailed oral and written information about the study, including the associated risks, benefits, and alternative therapies, and signed an informed consent form before any study procedures.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}}]}}