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Scar outcomes were assessed over 12 months using the Patient and Observer Scar Assessment Scale (POSAS), modified Vancouver Scar Scale (mVSS), 3D imaging, colorimetry, and adverse event reports.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Both BTX-A and CO\n 2<\/jats:sub>\n AFL-IPL groups showed significantly improved POSAS and mVSS scores compared to the control group at 6 and 12 months (\n p<\/jats:italic>\n < 0.001), with no significant difference between the two treatment arms. BTX-A treatment had fewer adverse events and lower pain scores. Colorimetry and 3D imaging revealed no significant differences between groups.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Both BTX-A and CO\n 2<\/jats:sub>\n AFL-IPL effectively prevented post-thyroidectomy scarring, each outperforming silicone dressings. While their efficacy was comparable, BTX-A offered greater convenience, safety, and patient comfort, making it a more practical option for routine clinical use, with CO\n 2<\/jats:sub>\n AFL-IPL serving as an effective alternative where laser therapy is available.\n <\/jats:p>\n <\/jats:sec>\n \n Level of Evidence I<\/jats:title>\n \n This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors\n www.springer.com\/00266<\/jats:ext-link>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1007\/s00266-026-05717-2","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T16:03:57Z","timestamp":1774454637000},"page":"3510-3522","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Combination Therapy of Intense Pulsed Light and Fractional Carbon Dioxide Laser Versus Botulinum Toxin Type A in Post-thyroidectomy Scar Prevention: A Prospective, Randomized Controlled Trial"],"prefix":"10.1007","volume":"50","author":[{"given":"Rong Xin","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen Jiang","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Yi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian Ming","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Dong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian Kun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2692-0744","authenticated-orcid":false,"given":"Gang","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,25]]},"reference":[{"key":"5717_CR1","doi-asserted-by":"publisher","first-page":"2567","DOI":"10.1097\/CM9.0000000000003284","volume":"137","author":"Z Lyu","year":"2024","unstructured":"Lyu Z, Zhang Y, Sheng C, Huang Y, Zhang Q, Chen K. 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