{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:22:39Z","timestamp":1791901359340,"version":"4.3.4"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Allergan Aesthetics, an AbbVie Company"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Aesth Plast Surg"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The definition of health encompasses mental, emotional, and social well-being, rather than simply the absence of disease. As a result, corrective aesthetic treatments are increasingly being viewed as an integral component of overall health rather than confined solely to the domain of aesthetics. In the realm of facial aesthetics, the corrective patient archetype is distinctly focused on rebalancing or proportioning facial features to improve confidence and self-perception. Minimally invasive treatments, such as botulinum toxin and hyaluronic acid (HA) gels, are known for their efficacy, tolerability, and ability to improve psychological and social outcomes. Additionally, hybrid injectables are gaining traction for their immediate filling and lifting effects that also provide biostimulating effects over time in the injected area.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Here, we present a clinical review of the literature, accompanied by examples that illustrate the practical application of onabotulinumtoxinA, HA gels, and hybrid injectables (HA and calcium hydroxyapatite; Allergan Aesthetics, an AbbVie Company) for patients seeking corrections, including facial asymmetries (e.g., facial paralysis and hemifacial microsomia), trauma, and scarring, emphasizing the importance of tailored approaches to achieve optimal outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results and Conclusions<\/jats:title>\n                    <jats:p>OnabotulinumtoxinA, HA gels, and hybrid injectables were effective, tolerable, and enhanced patients\u2019 quality of life by addressing both aesthetic and functional concerns. Overall, further research is needed to refine these treatments and expand their applications in corrective aesthetic medicine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence IV<\/jats:title>\n                    <jats:p>\n                      This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors\u00a0\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.springer.com\/00266\" ext-link-type=\"uri\">www.springer.com\/00266<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00266-026-05747-w","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T18:33:19Z","timestamp":1776364399000},"page":"4461-4475","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Minimally Invasive Aesthetic Treatments for the Corrective Patient Archetype: Transforming Lives"],"prefix":"10.1007","volume":"50","author":[{"given":"Isaac","family":"Shturman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamilton","family":"Garz\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Coimbra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Villafranca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Zimbres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"de los Angeles Pyke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Van Der Graaff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luiza","family":"Dabronzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,16]]},"reference":[{"issue":"2","key":"5747_CR1","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1111\/jocd.13227","volume":"19","author":"S Liew","year":"2020","unstructured":"Liew S, Silberberg M, Chantrey J. Understanding and treating different patient archetypes in aesthetic medicine. J Cosmet Dermatol. 2020;19(2):296\u2013302.","journal-title":"J Cosmet Dermatol"},{"issue":"3","key":"5747_CR2","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1111\/ajd.13273","volume":"61","author":"GJ Goodman","year":"2020","unstructured":"Goodman GJ, Liew S, Callan P, Hart S. Facial aesthetic injections in clinical practice: pretreatment and posttreatment consensus recommendations to minimise adverse outcomes. Australas J Dermatol. 2020;61(3):217\u201325.","journal-title":"Australas J Dermatol"},{"issue":"6","key":"5747_CR3","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1016\/j.jaad.2009.06.040","volume":"61","author":"MF Brin","year":"2009","unstructured":"Brin MF, Boodhoo TI, Pogoda JM, James LM, Demos G, Terashima Y, et al. Safety and tolerability of onabotulinumtoxinA in the treatment of facial lines: a meta-analysis of individual patient data from global clinical registration studies in 1678 participants. J Am Acad Dermatol. 2009;61(6):961\u201370.","journal-title":"J Am Acad Dermatol"},{"issue":"5","key":"5747_CR4","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1111\/dsu.12463","volume":"40","author":"M Cavallini","year":"2014","unstructured":"Cavallini M, Cirillo P, Fundaro SP, Quartucci S, Sciuto C, Sito G, et al. Safety of botulinum toxin A in aesthetic treatments: a systematic review of clinical studies. Dermatol Surg. 2014;40(5):525\u201336.","journal-title":"Dermatol Surg"},{"issue":"5","key":"5747_CR5","first-page":"309","volume":"98","author":"J Dong","year":"2016","unstructured":"Dong J, Gantz M, Goldenberg G. Efficacy and safety of new dermal fillers. Cutis. 2016;98(5):309\u201313.","journal-title":"Cutis"},{"key":"5747_CR6","first-page":"295","volume":"6","author":"D Funt","year":"2013","unstructured":"Funt D, Pavicic T. Dermal fillers in aesthetics: an overview of adverse events and treatment approaches. Clin Cosmet Investig Dermatol. 2013;6:295\u2013316.","journal-title":"Clin Cosmet Investig Dermatol"},{"issue":"19","key":"5747_CR7","doi-asserted-by":"publisher","first-page":"1818","DOI":"10.1212\/WNL.0000000000002560","volume":"86","author":"DM Simpson","year":"2016","unstructured":"Simpson DM, Hallett M, Ashman EJ, Comella CL, Green MW, Gronseth GS, et al. Practice guideline update summary: botulinum neurotoxin for the treatment of blepharospasm, cervical dystonia, adult spasticity, and headache: report of the guideline development subcommittee of the American academy of neurology. Neurology. 2016;86(19):1818\u201326.","journal-title":"Neurology"},{"key":"5747_CR8","volume-title":"Spasticity in adults: management using botulinum toxin. national guidelines","author":"Royal College of Physicians","year":"2018","unstructured":"Royal College of Physicians. Spasticity in adults: management using botulinum toxin. national guidelines. 2nd ed. London: Royal College of Physicians; 2018.","edition":"2nd ed"},{"key":"5747_CR9","doi-asserted-by":"crossref","unstructured":"American Urogynecologic Society, American College of Obstetricians and Gynecologists. Committee opinion: onabotulinumtoxinA and the bladder. Female Pelvic Med Reconstr Surg. 2014;20(5):245-7.","DOI":"10.1097\/SPV.0000000000000112"},{"key":"5747_CR10","volume-title":"Diagnosis and treatment of non-neurogenic overactive bladder (OAB) in adults: an AUA\/SUFU guideline","author":"EA Gormley","year":"2019","unstructured":"Gormley EA, Lightner DJ, Burgio KL, Chai TC, Clemens JQ, Culkin DJ, et al. Diagnosis and treatment of non-neurogenic overactive bladder (OAB) in adults: an AUA\/SUFU guideline. Linthicum, MD: American Urological Association; 2019."},{"issue":"5","key":"5747_CR11","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1097\/PRS.0000000000002119","volume":"137","author":"H Sundaram","year":"2016","unstructured":"Sundaram H, Liew S, Signorini M, Vieira Braz A, Fagien S, Swift A, et al. Global aesthetics consensus: hyaluronic acid fillers and botulinum toxin type A\u2014recommendations for combined treatment and optimizing outcomes in diverse patient populations. Plast Reconstr Surg. 2016;137(5):1410\u201323.","journal-title":"Plast Reconstr Surg"},{"issue":"1-2","key":"5747_CR12","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.jns.2014.12.030","volume":"349","author":"J Jankovic","year":"2015","unstructured":"Jankovic J, Adler CH, Charles D, Comella C, Stacy M, Schwartz M, et al. Primary results from the cervical dystonia patient registry for observation of onabotulinumtoxinA efficacy (CD PROBE). J Neurol Sci. 2015;349(1\u20132):84\u201393.","journal-title":"J Neurol Sci"},{"issue":"12","key":"5747_CR13","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1097\/PHM.0000000000000781","volume":"96","author":"A Esquenazi","year":"2017","unstructured":"Esquenazi A, Lee S, Mayer N, Garreta R, Patel A, Elovic E, et al. Patient registry of spasticity care world: data analysis based on physician experience. Am J Phys Med Rehabil. 2017;96(12):881\u20138.","journal-title":"Am J Phys Med Rehabil"},{"issue":"2","key":"5747_CR14","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.pmrj.2016.06.016","volume":"9","author":"DM Simpson","year":"2017","unstructured":"Simpson DM, Patel AT, Alfaro A, Ayyoub Z, Charles D, Dashtipour K, et al. OnabotulinumtoxinA injection for poststroke upper-limb spasticity: guidance for early injectors from a Delphi panel process. PM R. 2017;9(2):136\u201348.","journal-title":"PM R"},{"issue":"9","key":"5747_CR15","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1111\/j.1526-4610.2010.01766.x","volume":"50","author":"A Blumenfeld","year":"2010","unstructured":"Blumenfeld A, Silberstein SD, Dodick DW, Aurora SK, Turkel CC, Binder WJ. Method of injection of onabotulinumtoxinA for chronic migraine: a safe, well-tolerated, and effective treatment paradigm based on the PREEMPT clinical program. Headache. 2010;50(9):1406\u201318.","journal-title":"Headache"},{"issue":"5","key":"5747_CR16","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1111\/head.13074","volume":"57","author":"AM Blumenfeld","year":"2017","unstructured":"Blumenfeld AM, Silberstein SD, Dodick DW, Aurora SK, Brin MF, Binder WJ. Insights into the functional anatomy behind the PREEMPT injection paradigm: guidance on achieving optimal outcomes. Headache. 2017;57(5):766\u201377.","journal-title":"Headache"},{"issue":"1","key":"5747_CR17","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-018-0840-8","volume":"19","author":"AM Blumenfeld","year":"2018","unstructured":"Blumenfeld AM, Stark RJ, Freeman MC, Orejudos A, Manack Adams A. Long-term study of the efficacy and safety of onabotulinumtoxinA for the prevention of chronic migraine: COMPEL study. J Headache Pain. 2018;19(1):13.","journal-title":"J Headache Pain"},{"issue":"4","key":"5747_CR18","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1136\/jnnp.2008.159657","volume":"80","author":"DM Simpson","year":"2009","unstructured":"Simpson DM, Gracies JM, Yablon SA, Barbano R, Brashear A. Botulinum neurotoxin versus tizanidine in upper limb spasticity: a placebo-controlled study. J Neurol Neurosurg Psychiatry. 2009;80(4):380\u20135.","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"19","key":"5747_CR19","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.1056\/NEJMoa1208872","volume":"367","author":"AG Visco","year":"2012","unstructured":"Visco AG, Brubaker L, Richter HE, Nygaard I, Paraiso MF, Menefee SA, et al. Anticholinergic therapy versus onabotulinumtoxina for urgency urinary incontinence. N Engl J Med. 2012;367(19):1803\u201313.","journal-title":"N Engl J Med"},{"issue":"7","key":"5747_CR20","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1093\/asj\/sjw079","volume":"36","author":"S Liew","year":"2016","unstructured":"Liew S, Scamp T, de Maio M, Halstead M, Johnston N, Silberberg M, et al. Efficacy and safety of a hyaluronic acid filler to correct aesthetically detracting or deficient features of the Asian nose: a prospective, open-label, long-term study. Aesthet Surg J. 2016;36(7):760\u201372.","journal-title":"Aesthet Surg J"},{"key":"5747_CR21","doi-asserted-by":"publisher","first-page":"267","DOI":"10.2147\/CCID.S239667","volume":"13","author":"P Ogilvie","year":"2020","unstructured":"Ogilvie P, Thulesen J, Leys C, Sykianakis D, Chantrey J, Safa M, et al. Expert consensus on injection technique and area-specific recommendations for the hyaluronic acid dermal filler VYC-12L to treat fine cutaneous lines. Clin Cosmet Investig Dermatol. 2020;13:267\u201374.","journal-title":"Clin Cosmet Investig Dermatol"},{"issue":"5","key":"5747_CR22","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1001\/jamafacial.2018.0230","volume":"20","author":"MB Hall","year":"2018","unstructured":"Hall MB, Roy S, Buckingham ED. Novel use of a volumizing hyaluronic acid filler for treatment of infraorbital hollows. JAMA Facial Plast Surg. 2018;20(5):367\u201372.","journal-title":"JAMA Facial Plast Surg"},{"issue":"10","key":"5747_CR23","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1097\/DSS.0000000000001127","volume":"43","author":"F Niforos","year":"2017","unstructured":"Niforos F, Acquilla R, Ogilvie P, Safa M, Signorini M, Creutz L, et al. A prospective, open-label study of hyaluronic acid-based filler with lidocaine (VYC-15L) treatment for the correction of infraorbital skin depressions. Dermatol Surg. 2017;43(10):1271\u201380.","journal-title":"Dermatol Surg"},{"issue":"3","key":"5747_CR24","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1097\/DSS.0000000000002057","volume":"46","author":"P Ogilvie","year":"2020","unstructured":"Ogilvie P, Fink B, Leys C, Lipko-Godlewska S, Niforos F, Kelly K, et al. Improvement of radial cheek lines with hyaluronic acid-based dermal filler VYC-17.5L: results of the BEAM study. Dermatol Surg. 2020;46(3):376\u201385.","journal-title":"Dermatol Surg"},{"key":"5747_CR25","unstructured":"International Society of Aesthetic Plastic Surgery. ISAPS international survey on aesthetic\/cosmetic procedures performed in 2022. 2023. Available at: https:\/\/www.isaps.org\/discover\/about-isaps\/global-statistics\/global-survey-2022-full-report-and-press-releases\/. Accessed June 5, 2025."},{"key":"5747_CR26","unstructured":"International Society of Aesthetic Plastic Surgery. ISAPS international survey on aesthetic\/cosmetic procedures performed in 2023. 2024. Available at: https:\/\/www.isaps.org\/discover\/about-isaps\/global-statistics\/global-survey-2023-full-report-and-press-releases\/International Society of Aesthetic Plastic Surgery; 2024. Accessed June 5, 2025."},{"issue":"9","key":"5747_CR27","first-page":"e6190","volume":"12","author":"A Braz","year":"2024","unstructured":"Braz A, de Paula Eduardo CC, Pierce A, Grond A, Kutikov A, Nakab L. A novel hybrid injectable for soft-tissue augmentation: analysis of data and practical experience. Plast Reconstr Surg. 2024;12(9):e6190.","journal-title":"Plast Reconstr Surg"},{"issue":"6","key":"5747_CR28","doi-asserted-by":"publisher","first-page":"e5055","DOI":"10.1097\/GOX.0000000000005055","volume":"11","author":"BSF Bravo","year":"2023","unstructured":"Bravo BSF, de Almeida TSC, Carvalho RM, Machado CJ, Bravo LG, Elias MC. Dermal thickness increase and aesthetic improvement with hybrid product combining hyaluronic acid and calcium hydroxyapatite: a clinical and sonographic analysis. Plast Reconstr Surg Glob Open. 2023;11(6):e5055.","journal-title":"Plast Reconstr Surg Glob Open"},{"issue":"8","key":"5747_CR29","doi-asserted-by":"publisher","first-page":"2186","DOI":"10.1111\/jocd.15706","volume":"22","author":"F Urdiales-G\u00e1lvez","year":"2023","unstructured":"Urdiales-G\u00e1lvez F, Braz A, Cavallini M. Facial rejuvenation with the new hybrid filler HArmonyCa(TM): clinical and aesthetic outcomes assessed by 2D and 3D photographs, ultrasound, and elastography. J Cosmet Dermatol. 2023;22(8):2186\u201397.","journal-title":"J Cosmet Dermatol"},{"issue":"12","key":"5747_CR30","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1093\/asj\/sjy239","volume":"39","author":"S Dayan","year":"2019","unstructured":"Dayan S, Rivkin A, Sykes JM, Teller CF, Weinkle SH, Shumate GT, et al. Aesthetic treatment positively impacts social perception: analysis of subjects from the HARMONY study. Aesthet Surg J. 2019;39(12):1380\u20139.","journal-title":"Aesthet Surg J"},{"issue":"2","key":"5747_CR31","doi-asserted-by":"publisher","first-page":"NP115","DOI":"10.1093\/asj\/sjab114","volume":"42","author":"JL Cohen","year":"2022","unstructured":"Cohen JL, Rivkin A, Dayan S, Shamban A, Werschler WP, Teller CF, et al. Multimodal facial aesthetic treatment on the appearance of aging, social confidence, and psychological wellbeing: HARMONY study. Aesthet Surg J. 2022;42(2):NP115\u201324.","journal-title":"Aesthet Surg J"},{"issue":"3","key":"5747_CR32","doi-asserted-by":"publisher","first-page":"161","DOI":"10.3390\/toxins16030161","volume":"16","author":"F Carr\u00e9","year":"2024","unstructured":"Carr\u00e9 F, Amar J, Tank\u00e9r\u00e9 F, Foirest C. Botulinum toxin injections to manage sequelae of peripheral facial palsy. Toxins (Basel). 2024;16(3):161.","journal-title":"Toxins (Basel)."},{"issue":"4","key":"5747_CR33","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1097\/MOO.0000000000000176","volume":"23","author":"JA Cabin","year":"2015","unstructured":"Cabin JA, Massry GG, Azizzadeh B. Botulinum toxin in the management of facial paralysis. Curr Opin Otolaryngol Head Neck Surg. 2015;23(4):272\u201380.","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"issue":"3","key":"5747_CR34","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1007\/s00266-022-03193-y","volume":"47","author":"DD Coimbra","year":"2023","unstructured":"Coimbra DD, Stefanello B. Myomodulation with facial fillers: a comprehensive technical guide and retrospective case series. Aesthetic Plast Surg. 2023;47(3):1162\u201374.","journal-title":"Aesthetic Plast Surg"},{"issue":"3","key":"5747_CR35","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1007\/s00266-018-1116-z","volume":"42","author":"M de Maio","year":"2018","unstructured":"de Maio M. Myomodulation with injectable fillers: an innovative approach to addressing facial muscle movement. Aesthetic Plast Surg. 2018;42(3):798\u2013814.","journal-title":"Aesthetic Plast Surg"},{"issue":"3","key":"5747_CR36","doi-asserted-by":"publisher","first-page":"77","DOI":"10.15406\/jdc.2024.08.00271","volume":"8","author":"R Denkova","year":"2024","unstructured":"Denkova R, Stoycheva Z, Zvolinska A, Cavallini M. Myomodulation with HA fillers: a novel non-surgical therapy for facial paralysis. J Dermatol Cosmetol. 2024;8(3):77\u201381.","journal-title":"J Dermatol Cosmetol"},{"issue":"2","key":"5747_CR37","first-page":"41","volume":"26","author":"A Sahan","year":"2017","unstructured":"Sahan A, Tamer F. Restoring facial symmetry through non-surgical cosmetic procedures after permanent facial paralysis: a case report. Acta Dermatovenerol Alp Pannonica Adriat. 2017;26(2):41\u20132.","journal-title":"Acta Dermatovenerol Alp Pannonica Adriat"},{"issue":"4","key":"5747_CR38","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1007\/s12663-023-02053-9","volume":"22","author":"NVV Reddy","year":"2023","unstructured":"Reddy NVV, Potturi A, Rajan R, Jhawar D, Bharath Bhushan YW, Pasupuleti A. Facial asymmetry\u2014demystifying the entity. J Maxillofac Oral Surg. 2023;22(4):749\u201361.","journal-title":"J Maxillofac Oral Surg"},{"issue":"2","key":"5747_CR39","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1007\/s00266-017-1008-7","volume":"42","author":"SH Lee","year":"2018","unstructured":"Lee SH, Min HJ, Kim YW, Cheon YW. The efficacy and safety of early postoperative botulinum toxin A injection for facial scars. Aesthetic Plast Surg. 2018;42(2):530\u20137.","journal-title":"Aesthetic Plast Surg"},{"issue":"Pt B","key":"5747_CR40","doi-asserted-by":"publisher","first-page":"1682","DOI":"10.1016\/j.ijbiomac.2018.09.188","volume":"120","author":"SNA Bukhari","year":"2018","unstructured":"Bukhari SNA, Roswandi NL, Waqas M, Habib H, Hussain F, Khan S, et al. Hyaluronic acid, a promising skin rejuvenating biomedicine: a review of recent updates and pre-clinical and clinical investigations on cosmetic and nutricosmetic effects. Int J Biol Macromol. 2018;120(Pt B):1682\u201395.","journal-title":"Int J Biol Macromol"},{"key":"5747_CR41","doi-asserted-by":"publisher","first-page":"285","DOI":"10.2147\/CCID.S132626","volume":"10","author":"SN Hussain","year":"2017","unstructured":"Hussain SN, Goodman GJ, Rahman E. Treatment of a traumatic atrophic depressed scar with hyaluronic acid fillers: a case report. Clin Cosmet Investig Dermatol. 2017;10:285\u20137.","journal-title":"Clin Cosmet Investig Dermatol"},{"issue":"12","key":"5747_CR42","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1097\/DSS.0000000000004315","volume":"50","author":"R Siperstein","year":"2024","unstructured":"Siperstein R, Nestor E, Meran S. Prospective clinical trial demonstrating the efficacy of hyaluronic acid filler for the improvement of atrophic facial scars up to 2 years. Dermatol Surg. 2024;50(12):1143\u20138.","journal-title":"Dermatol Surg"},{"issue":"1","key":"5747_CR43","first-page":"1","volume":"4","author":"R Rauso","year":"2020","unstructured":"Rauso R. HA fillers: a new \u201ctool\u201d to face facial post surgical deformities? J Clin Cosmet Dermatol. 2020;4(1):1\u20132.","journal-title":"J Clin Cosmet Dermatol."},{"issue":"5","key":"5747_CR44","first-page":"486","volume":"7","author":"DA Kasper","year":"2008","unstructured":"Kasper DA, Cohen JL, Saxena A, Morganroth GS. Fillers for postsurgical depressed scars after skin cancer reconstruction. J Drugs Dermatol. 2008;7(5):486\u20137.","journal-title":"J Drugs Dermatol"},{"issue":"7","key":"5747_CR45","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1185\/030079904125003962","volume":"20","author":"M Naumann","year":"2004","unstructured":"Naumann M, Jankovic J. Safety of botulinum toxin type A: a systematic review and meta-analysis. Curr Med Res Opin. 2004;20(7):981\u201390.","journal-title":"Curr Med Res Opin"},{"key":"5747_CR46","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.toxicon.2014.07.009","volume":"90","author":"J Ramirez-Castaneda","year":"2014","unstructured":"Ramirez-Castaneda J, Jankovic J. Long-term efficacy, safety, and side effect profile of botulinum toxin in dystonia: a 20-year follow-up. Toxicon. 2014;90:344\u20138.","journal-title":"Toxicon"},{"issue":"11","key":"5747_CR47","doi-asserted-by":"publisher","first-page":"1602","DOI":"10.1111\/dsu.12343","volume":"39","author":"D Jones","year":"2013","unstructured":"Jones D, Murphy DK. Volumizing hyaluronic acid filler for midface volume deficit: 2-year results from a pivotal single-blind randomized controlled study. Dermatol Surg. 2013;39(11):1602\u201311.","journal-title":"Dermatol Surg"},{"issue":"5","key":"5747_CR48","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1097\/DSS.0000000000001529","volume":"44","author":"G Monheit","year":"2018","unstructured":"Monheit G, Beer K, Hardas B, Grimes PE, Weichman BM, Murphy DK, et al. Safety and effectiveness of the hyaluronic acid dermal filler VYC-17.5L for nasolabial folds: results of a randomized, controlled study. Dermatol Surg. 2018;44(5):670\u20138.","journal-title":"Dermatol Surg"},{"issue":"3","key":"5747_CR49","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1097\/DSS.0000000000001035","volume":"43","author":"RG Geronemus","year":"2017","unstructured":"Geronemus RG, Bank DE, Hardas B, Shamban A, Weichman BM, Murphy DK. Safety and effectiveness of VYC-15L, a hyaluronic acid filler for lip and perioral enhancement: one-year results from a randomized, controlled study. Dermatol Surg. 2017;43(3):396\u2013404.","journal-title":"Dermatol Surg"},{"key":"5747_CR50","doi-asserted-by":"publisher","first-page":"791","DOI":"10.2147\/CCID.S216222","volume":"12","author":"F Niforos","year":"2019","unstructured":"Niforos F, Ogilvie P, Cavallini M, Leys C, Chantrey J, Safa M, et al. VYC-12 injectable gel is safe and effective for improvement of facial skin topography: a prospective study. Clin Cosmet Investig Dermatol. 2019;12:791\u20138.","journal-title":"Clin Cosmet Investig Dermatol"},{"issue":"9","key":"5747_CR51","doi-asserted-by":"publisher","first-page":"NP499","DOI":"10.1093\/asj\/sjaa013","volume":"40","author":"P Ogilvie","year":"2020","unstructured":"Ogilvie P, Benouaiche L, Philipp-Dormston WG, Belhaouari L, Gaymans F, Sattler G, et al. VYC-25L hyaluronic acid injectable gel is safe and effective for long-term restoration and creation of volume of the lower face. Aesthet Surg J. 2020;40(9):NP499-510.","journal-title":"Aesthet Surg J"},{"issue":"6","key":"5747_CR52","doi-asserted-by":"publisher","first-page":"853","DOI":"10.5114\/ada.2019.82795","volume":"37","author":"H Witmanowski","year":"2020","unstructured":"Witmanowski H, B\u0142ochowiak K. The whole truth about botulinum toxin\u2014a review. Adv Dermatol Allergol. 2020;37(6):853\u201361.","journal-title":"Adv Dermatol Allergol"},{"issue":"7","key":"5747_CR53","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1111\/jdv.14295","volume":"31","author":"WG Philipp-Dormston","year":"2017","unstructured":"Philipp-Dormston WG, Bergfeld D, Sommer BM, Sattler G, Cotofana S, Snozzi P, et al. Consensus statement on prevention and management of adverse effects following rejuvenation procedures with hyaluronic acid based fillers. J Eur Acad Dermatol Venereol. 2017;31(7):1088\u201395.","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"5747_CR54","doi-asserted-by":"publisher","first-page":"205","DOI":"10.2147\/CCID.S80446","volume":"8","author":"K De Boulle","year":"2015","unstructured":"De Boulle K, Heydenrych I. Patient factors influencing dermal filler complications: prevention, assessment, and treatment. Clin Cosmet Investig Dermatol. 2015;8:205\u201314.","journal-title":"Clin Cosmet Investig Dermatol"},{"issue":"3","key":"5747_CR55","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1007\/s00266-017-0798-y","volume":"41","author":"F Urdiales-Galvez","year":"2017","unstructured":"Urdiales-Galvez F, Delgado NE, Figueiredo V, Lajo-Plaza JV, Mira M, Ortiz-Marti F, et al. Preventing the complications associated with the use of dermal fillers in facial aesthetic procedures: an expert group consensus report. Aesthetic Plast Surg. 2017;41(3):667\u201377.","journal-title":"Aesthetic Plast Surg"},{"key":"5747_CR56","doi-asserted-by":"publisher","first-page":"603","DOI":"10.2147\/CCID.S180904","volume":"11","author":"I Heydenrych","year":"2018","unstructured":"Heydenrych I, Kapoor KM, De Boulle K, Goodman G, Swift A, Kumar N, et al. A 10-point plan for avoiding hyaluronic acid dermal filler-related complications during facial aesthetic procedures and algorithms for management. Clin Cosmet Investig Dermatol. 2018;11:603\u201311.","journal-title":"Clin Cosmet Investig Dermatol"},{"issue":"6","key":"5747_CR57","doi-asserted-by":"publisher","first-page":"961e","DOI":"10.1097\/PRS.0000000000002184","volume":"137","author":"M Signorini","year":"2016","unstructured":"Signorini M, Liew S, Sundaram H, De Boulle KL, Goodman GJ, Monheit G, et al. Global aesthetics consensus: Avoidance and management of complications from hyaluronic acid fillers\u2014evidence- and opinion-based review and consensus recommendations. Plast Reconstr Surg. 2016;137(6):961e-e971.","journal-title":"Plast Reconstr Surg"},{"key":"5747_CR58","doi-asserted-by":"publisher","first-page":"779","DOI":"10.2147\/CCID.S315711","volume":"14","author":"I Heydenrych","year":"2021","unstructured":"Heydenrych I, De Boulle K, Kapoor KM, Bertossi D. The 10-point plan 2021: updated concepts for improved procedural safety during facial filler treatments. Clin Cosmet Investig Dermatol. 2021;14:779\u2013814.","journal-title":"Clin Cosmet Investig Dermatol"},{"issue":"2","key":"5747_CR59","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1007\/s00266-017-1063-0","volume":"42","author":"F Urdiales-Galvez","year":"2018","unstructured":"Urdiales-Galvez F, Delgado NE, Figueiredo V, Lajo-Plaza JV, Mira M, Moreno A, et al. Treatment of soft tissue filler complications: expert consensus recommendations. Aesthetic Plast Surg. 2018;42(2):498\u2013510.","journal-title":"Aesthetic Plast Surg"},{"issue":"7","key":"5747_CR60","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1093\/asj\/sjv018","volume":"35","author":"JL Cohen","year":"2015","unstructured":"Cohen JL, Biesman BS, Dayan SH, DeLorenzi C, Lambros VS, Nestor MS, et al. Treatment of hyaluronic acid filler-induced impending necrosis with hyaluronidase: consensus recommendations. Aesthet Surg J. 2015;35(7):844\u20139.","journal-title":"Aesthet Surg J"}],"container-title":["Aesthetic Plastic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00266-026-05747-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00266-026-05747-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00266-026-05747-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T15:03:31Z","timestamp":1782745411000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00266-026-05747-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,16]]},"references-count":60,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["5747"],"URL":"https:\/\/doi.org\/10.1007\/s00266-026-05747-w","relation":{},"ISSN":["0364-216X","1432-5241"],"issn-type":[{"value":"0364-216X","type":"print"},{"value":"1432-5241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,16]]},"assertion":[{"value":"2 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Daniel Coimbra: Speaker, Allergan Aesthetics, an AbbVie Company. Hamilton Garz\u00f3n: No conflicts to disclose. Isaac Shturman: Speaker and consultant for Allergan Aesthetics, an AbbVie Company. Jorge Villafranca: Speaker and consultant for Allergan Aesthetics, an AbbVie Company. Silvia Zimbres: Medical consultant and speaker for AbbVie\/Allergan Aesthetics, an AbbVie Company, Johnson & Johnson\/Kenvue, Neauvia, NAOS, and L\u2019Or\u00e9al. Maria de los Angeles Pyke, Irina Van Der Graaff, and Maria Luiza Dabronzo: full-time employees of AbbVie and may own AbbVie stock.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and Animal Rights"}},{"value":"All participants give their informed consent in writing prior to inclusion in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}}]}}