{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T15:43:51Z","timestamp":1782747831786,"version":"3.54.5"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Aesth Plast Surg"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1007\/s00266-026-05801-7","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:11:56Z","timestamp":1777392716000},"page":"3785-3793","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Single-Stage Reconstruction with a Bilayer Artificial Dermal Regeneration Matrix for Nasal Skin Malignancies Defects in Middle-Aged and Elderly Asian Patients: Minimizing Scarring and Morbidity"],"prefix":"10.1007","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4640-3783","authenticated-orcid":false,"given":"Huafeng","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weilin","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingping","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"issue":"3","key":"5801_CR1","doi-asserted-by":"publisher","first-page":"143","DOI":"10.7181\/acfs.2020.00234","volume":"21","author":"TK Kim","year":"2020","unstructured":"Kim TK, Jeong JY. Surgical anatomy for Asian rhinoplasty: Part II. Arch Craniofac Surg. 2020;21(3):143\u201355.","journal-title":"Arch Craniofac Surg."},{"issue":"4","key":"5801_CR2","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1055\/s-0035-1564818","volume":"29","author":"J Park","year":"2015","unstructured":"Park J, Suhk J, Nguyen AH. Nasal analysis and anatomy: anthropometric proportional assessment in asians-aesthetic balance from forehead to chin. Part II Semin Plast Surg. 2015;29(4):226\u201331.","journal-title":"Part II. Semin Plast Surg."},{"issue":"5","key":"5801_CR3","doi-asserted-by":"publisher","first-page":"268","DOI":"10.7181\/acfs.2021.00465","volume":"22","author":"IS Koh","year":"2021","unstructured":"Koh IS, Sun H. A practical approach to nasal reconstruction in Asian patients. Arch Craniofac Surg. 2021;22(5):268\u201375.","journal-title":"Arch Craniofac Surg."},{"issue":"9","key":"5801_CR4","doi-asserted-by":"publisher","first-page":"2668","DOI":"10.3390\/ijms19092668","volume":"19","author":"S Del Bino","year":"2018","unstructured":"Del Bino S, Duval C, Bernerd F. Clinical and biological characterization of skin pigmentation diversity and its consequences on UV impact. Int J Mol Sci. 2018;19(9):2668.","journal-title":"Int J Mol Sci"},{"issue":"4","key":"5801_CR5","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1055\/s-0035-1564815","volume":"29","author":"MJ Lee","year":"2015","unstructured":"Lee MJ, Song H-M. Asian rhinoplasty with rib cartilage. Semin Plast Surg. 2015;29(4):262\u20138.","journal-title":"Semin Plast Surg"},{"key":"5801_CR6","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.msec.2015.03.013","volume":"52","author":"F Wang","year":"2015","unstructured":"Wang F, Wang M, She Z, Fan K, Xu C, Chu B, et al. Collagen\/chitosan based two-compartment and bi-functional dermal scaffolds for skin regeneration. Mater Sci Eng C Mater Biol Appl. 2015;52:155\u201362.","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"issue":"3","key":"5801_CR7","doi-asserted-by":"publisher","first-page":"e0120322","DOI":"10.1371\/journal.pone.0120322","volume":"10","author":"ACC Wosgrau","year":"2015","unstructured":"Wosgrau ACC, Jeremias TdS, Leonardi DF, Pereima MJ, Di Giunta G, Trentin AG. Comparative experimental study of wound healing in mice: pelnac versus integra. PLoS ONE. 2015;10(3):e0120322.","journal-title":"PLoS ONE"},{"key":"5801_CR8","unstructured":"National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: basal cell skin cancer (version 2.2026). https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/nmsc.pdf. Accessed 26 Apr 2026."},{"key":"5801_CR9","unstructured":"National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: squamous cell skin cancer (version 2.2026). https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/squamous.pdf. Accessed 26 Apr 2026."},{"issue":"12","key":"5801_CR10","first-page":"639","volume":"56","author":"L Losco","year":"2020","unstructured":"Losco L, Bolletta A, Pierazzi DM, Spadoni D, Cuomo R, Marcasciano M, et al. reconstruction of the nose: management of nasal cutaneous defects according to aesthetic subunit and defect size. A Rev Med (Kaunas). 2020;56(12):639.","journal-title":"A Rev. Med (Kaunas)"},{"issue":"3","key":"5801_CR11","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1055\/s-0041-1726024","volume":"37","author":"H Dereba\u015f\u0131nl\u0131o\u011flu","year":"2021","unstructured":"Dereba\u015f\u0131nl\u0131o\u011flu H, \u00d6zkaya NK. Analysis of basal cell carcinoma and squamous cell carcinoma according to nasal subunit location. Facial Plast Surg. 2021;37(3):407\u201310.","journal-title":"Facial Plast Surg"},{"issue":"3","key":"5801_CR12","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/s12070-021-02475-2","volume":"74","author":"JM N\u00fa\u00f1ez-Casta\u00f1eda","year":"2022","unstructured":"N\u00fa\u00f1ez-Casta\u00f1eda JM, Chang-Grozo SL. Surgical treatment and reconstruction of nasal defects according to the aesthetic subunits principles. Indian J Otolaryngol Head Neck Surg. 2022;74(3):305\u201313.","journal-title":"Indian J Otolaryngol Head Neck Surg."},{"issue":"7","key":"5801_CR13","doi-asserted-by":"publisher","first-page":"2224","DOI":"10.1097\/01.PRS.0000123614.73743.4D","volume":"113","author":"NM Blanco","year":"2004","unstructured":"Blanco NM, Edwards J, Zamboni WA. Dermal substitute (Integra) for open nasal wounds. Plast Reconstr Surg. 2004;113(7):2224\u20135.","journal-title":"Plast Reconstr Surg"},{"key":"5801_CR14","volume":"15","author":"MA Applebaum","year":"2015","unstructured":"Applebaum MA, Daggett JD, Carter WL. Nasal tip reconstruction using integra bilayer wound matrix: an alternative to the forehead flap. Eplasty. 2015;15:e52.","journal-title":"Eplasty"},{"issue":"4","key":"5801_CR15","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1097\/PRS.0000000000006072","volume":"144","author":"AK Seth","year":"2019","unstructured":"Seth AK, Ratanshi I, Dayan JH, Disa JJ, Mehrara BJ. Nasal reconstruction using the integra dermal regeneration template. Plast Reconstr Surg. 2019;144(4):966\u201370.","journal-title":"Plast Reconstr Surg"},{"issue":"1","key":"5801_CR16","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1055\/s-0042-1742750","volume":"36","author":"M Depani","year":"2022","unstructured":"Depani M, Grush AE, Parham MJ, Jones LM, Thornton JF. Use of biologic agents in nasal and scalp reconstruction. Semin Plast Surg. 2022;36(1):17\u201325.","journal-title":"Semin Plast Surg"},{"issue":"11","key":"5801_CR17","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000006319","volume":"12","author":"I Mataro","year":"2024","unstructured":"Mataro I, D\u2019Antonio S, D\u2019Alessio M, Petroccione C, D\u2019Angelo D, La Padula S, et al. Dermal substitute integra for the treatment of mammalian bite injuries of nose: a new reconstructive ladder. Plast Reconstr Surg Glob Open. 2024;12(11):e6319.","journal-title":"Plast Reconstr Surg Glob Open"},{"issue":"4","key":"5801_CR18","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1080\/2000656X.2017.1421547","volume":"52","author":"X Qiu","year":"2018","unstructured":"Qiu X, Wang J, Wang G, Wen H. Vascularization of Lando((R)) dermal scaffold in an acute full-thickness skin-defect porcine model. J Plast Surg Hand Surg. 2018;52(4):204\u20139.","journal-title":"J Plast Surg Hand Surg"}],"container-title":["Aesthetic Plastic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00266-026-05801-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00266-026-05801-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00266-026-05801-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T14:44:19Z","timestamp":1782744259000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00266-026-05801-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,28]]},"references-count":18,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["5801"],"URL":"https:\/\/doi.org\/10.1007\/s00266-026-05801-7","relation":{},"ISSN":["0364-216X","1432-5241"],"issn-type":[{"value":"0364-216X","type":"print"},{"value":"1432-5241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,28]]},"assertion":[{"value":"24 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"For this type of study formal consent is not required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}