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This study conducted a network meta-analysis to compare the efficacy of the combined treatment with that of the single laser treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed, Embase, Cochrane Library, and Web of Science databases were systematically searched up to 28 April 2025. Two independent reviewers conducted study selection, data extraction, and risk-of-bias assessment. The quality of the included studies was evaluated using the Risk of Bias (RoB) 2.0 tool. A Bayesian network meta-analysis model was employed to calculate the standardized mean difference (SMD) and corresponding 95% confidence intervals (CIs) for VSS scores. Treatment rankings were determined using the surface under the cumulative ranking curve (SUCRA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 14 randomized controlled trials were included, involving 326 patients. The network meta-analysis showed that the therapeutic effect of FCO\n                      <jats:sub>2<\/jats:sub>\n                      L combined with PDL was significantly better than that of the single therapy. Specifically: Compared with single PDL: SMD = \u2009\u2212\u20091.29 (95% CI: \u2009\u2212\u20091.94, \u2009\u2212\u20090.65). The SUCRA probability ranking showed that the combined ranking of FCO\n                      <jats:sub>2<\/jats:sub>\n                      L combined with PDL was the highest (probability &gt; 80%), followed by single FCO\n                      <jats:sub>2<\/jats:sub>\n                      L (70%-75%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The combined use of FCO\n                      <jats:sub>2<\/jats:sub>\n                      L and PDL has significant advantages in improving hypertrophic scars. Although using FCO\n                      <jats:sub>2<\/jats:sub>\n                      L alone is effective, its therapeutic effect is not as good as the combined strategy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence I<\/jats:title>\n                    <jats:p>\n                      This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.springer.com\/00266\" ext-link-type=\"uri\">www.springer.com\/00266<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00266-026-05829-9","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T16:19:45Z","timestamp":1776269985000},"page":"4450-4460","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Efficacy of Combined Carbon Dioxide Fractional Laser and Pulse Dye Laser versus Monotherapy for Hypertrophic Scars: A Network Meta-Analysis of Randomized Controlled Trials"],"prefix":"10.1007","volume":"50","author":[{"given":"Derong","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baiye","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaofan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwen","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingcheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xunyu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,15]]},"reference":[{"issue":"10052","key":"5829_CR1","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1016\/S0140-6736(16)31406-4","volume":"388","author":"CC Finnerty","year":"2016","unstructured":"Finnerty CC, Jeschke MG, Branski LK, Barret JP, Dziewulski P, Herndon DN. 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