{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T19:54:24Z","timestamp":1785527664328,"version":"3.56.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","award":["RFP-2022-P-002"],"award-info":[{"award-number":["RFP-2022-P-002"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Aesth Plast Surg"],"DOI":"10.1007\/s00266-026-05918-9","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T21:35:52Z","timestamp":1785274552000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Systemic Tacrolimus Attenuates Peri-Implant Capsule Formation and Inflammatory\/Fibrotic Signaling in a Rat Silicone Implant Model"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0096-7401","authenticated-orcid":false,"given":"Hyung Bae","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nara","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Ho","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Sup","family":"Eom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"5918_CR1","first-page":"165","volume":"18","author":"A Pirjavec Mahi\u0107","year":"2020","unstructured":"Pirjavec Mahi\u0107 A, Grebi\u0107 D, \u010cargonja P, Kusti\u0107 D. Silicone gel breast implants: past, present, and future. Acta Med Hist Adriat. 2020;18:165\u201376.","journal-title":"Acta Med Hist Adriat"},{"key":"5918_CR2","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1097\/SLA.0000000000002990","volume":"269","author":"CJ Coroneos","year":"2019","unstructured":"Coroneos CJ, Selber JC, Offodile AC 2nd, Butler CE, Clemens MW. US FDA breast implant postapproval studies: long-term outcomes in 99,993 patients. Ann Surg. 2019;269:30\u20136.","journal-title":"Ann Surg"},{"key":"5918_CR3","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1007\/s00266-021-02141-6","volume":"45","author":"Y Bachour","year":"2021","unstructured":"Bachour Y. Capsular contracture in breast implant surgery: where are we now and where are we going? Aesthet Plast Surg. 2021;45:1328\u201337.","journal-title":"Aesthet Plast Surg"},{"key":"5918_CR4","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1097\/PRS.0000000000007453","volume":"147","author":"O Haran","year":"2021","unstructured":"Haran O, Bracha G, Tiosano A, et al. Postirradiation capsular contracture in implant-based breast reconstruction: management and outcome. Plast Reconstr Surg. 2021;147:11\u20139.","journal-title":"Plast Reconstr Surg"},{"key":"5918_CR5","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.1097\/01.prs.0000222233.54505.d2","volume":"118","author":"A Araco","year":"2006","unstructured":"Araco A, Gravante G, Araco F, Delogu D, Cervelli V. Capsular contracture: results of 3002 patients with aesthetic breast augmentation. Plast Reconstr Surg. 2006;118:1499\u2013500.","journal-title":"Plast Reconstr Surg"},{"key":"5918_CR6","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1055\/s-0041-1731793","volume":"35","author":"T Safran","year":"2021","unstructured":"Safran T, Nepon H, Chu CK, et al. Current concepts in capsular contracture: pathophysiology, prevention, and management. Semin Plast Surg. 2021;35:189\u201397.","journal-title":"Semin Plast Surg"},{"key":"5918_CR7","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.jaut.2004.03.005","volume":"23","author":"D Wolfram","year":"2004","unstructured":"Wolfram D, Rainer C, Niederegger H, Piza H, Wick G. Cellular and molecular composition of fibrous capsules formed around silicone breast implants with special focus on local immune reactions. J Autoimmun. 2004;23:81\u201391.","journal-title":"J Autoimmun"},{"key":"5918_CR8","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1007\/s00266-019-01383-9","volume":"43","author":"Y Bachour","year":"2019","unstructured":"Bachour Y, Poort L, Verweij SP, et al. PCR characterization of microbiota on contracted and non-contracted breast capsules. Aesthet Plast Surg. 2019;43:918\u201326.","journal-title":"Aesthet Plast Surg"},{"key":"5918_CR9","first-page":"e2037","volume":"7","author":"JN Walker","year":"2019","unstructured":"Walker JN, Pinkner CL, Pinkner JS, Hultgren SJ, Myckatyn TM. The detection of bacteria and matrix proteins on clinically benign and pathologic implants. Plast Reconstr Surg. 2019;7:e2037.","journal-title":"Plast Reconstr Surg"},{"key":"5918_CR10","doi-asserted-by":"publisher","first-page":"E210","DOI":"10.1002\/lary.25178","volume":"125","author":"D Mizokami","year":"2015","unstructured":"Mizokami D, Araki K, Tanaka N, et al. Tacrolimus prevents laryngotracheal stenosis in an acute-injury rat model. Laryngoscope. 2015;125:E210\u20135.","journal-title":"Laryngoscope"},{"key":"5918_CR11","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1007\/s00266-018-1119-9","volume":"42","author":"O Colak","year":"2018","unstructured":"Colak O, Ozer K, Dikmen A, Ozakinci H, Ozkaya O. Evaluation of safe systemic immunosuppression created with dexamethasone in prevention of capsular contracture: a glance to distinct perspectives with Toll-like receptors. Aesthetic Plast Surg. 2018;42:1133\u201343.","journal-title":"Aesthetic Plast Surg"},{"key":"5918_CR12","doi-asserted-by":"publisher","first-page":"2025","DOI":"10.1097\/01.prs.0000287381.93729.e2","volume":"120","author":"OA Zimman","year":"2007","unstructured":"Zimman OA, Toblli J, Stella I, Ferder M, Ferder L, Inserra F. The effects of angiotensin-converting-enzyme inhibitors on the fibrous envelope around mammary implants. Plast Reconstr Surg. 2007;120:2025\u201333.","journal-title":"Plast Reconstr Surg"},{"key":"5918_CR13","doi-asserted-by":"publisher","first-page":"S40","DOI":"10.1006\/clin.1996.0140","volume":"80","author":"S Ho","year":"1996","unstructured":"Ho S, Clipstone N, Timmermann L, et al. The mechanism of action of cyclosporin A and FK506. Clin Immunol Immunopathol. 1996;80:S40-45.","journal-title":"Clin Immunol Immunopathol"},{"key":"5918_CR14","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1007\/s00392-005-0237-y","volume":"94","author":"B Scheller","year":"2005","unstructured":"Scheller B, Grandt A, Wnendt S, Lorenz G, B\u00f6hm M, Nickenig G. Comparative study of tacrolimus and paclitaxel stent coating in the porcine coronary model. Z Kardiol. 2005;94:445\u201352.","journal-title":"Z Kardiol"},{"key":"5918_CR15","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1007\/s00392-010-0165-3","volume":"99","author":"JM Siller-Matula","year":"2010","unstructured":"Siller-Matula JM, Tentzeris I, Vogel B, et al. Tacrolimus-eluting carbon-coated stents versus sirolimus-eluting stents for prevention of symptom-driven clinical end points. Clin Res Cardiol. 2010;99:645\u201350.","journal-title":"Clin Res Cardiol"},{"key":"5918_CR16","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.ejvs.2016.11.027","volume":"53","author":"K Ak","year":"2017","unstructured":"Ak K, Ak E, Dericioglu O, et al. Tacrolimus-eluting suture inhibits neointimal hyperplasia: an experimental in vivo study in rats. Eur J Vasc Endovasc Surg. 2017;53:431\u20137.","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"5918_CR17","doi-asserted-by":"publisher","first-page":"5039","DOI":"10.2174\/1381612825666181206123828","volume":"24","author":"S Kotta","year":"2018","unstructured":"Kotta S, Nair A, Alsabeelah N. 3D printing technology in drug delivery: recent progress and application. Curr Pharm Des. 2018;24:5039\u201348.","journal-title":"Curr Pharm Des"},{"key":"5918_CR18","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.actbio.2022.11.050","volume":"157","author":"SH Hwang","year":"2023","unstructured":"Hwang SH, Kim J, Heo C, et al. 3D printed multi-growth factor delivery patches fabricated using dual-crosslinked decellularized extracellular matrix-based hybrid inks to promote cerebral angiogenesis. Acta Biomater. 2023;157:137\u201348.","journal-title":"Acta Biomater"},{"key":"5918_CR19","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.jconrel.2016.06.015","volume":"238","author":"HG Yi","year":"2016","unstructured":"Yi HG, Choi YJ, Kang KS, et al. A 3D-printed local drug delivery patch for pancreatic cancer growth suppression. J Control Release. 2016;238:231\u201341.","journal-title":"J Control Release"},{"key":"5918_CR20","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1080\/17425247.2017.1247803","volume":"14","author":"L Elviri","year":"2017","unstructured":"Elviri L, Bianchera A, Bergonzi C, Bettini R. Controlled local drug delivery strategies from chitosan hydrogels for wound healing. Expert Opin Drug Deliv. 2017;14:897\u2013908.","journal-title":"Expert Opin Drug Deliv"}],"container-title":["Aesthetic Plastic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00266-026-05918-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00266-026-05918-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00266-026-05918-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:14:21Z","timestamp":1785521661000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00266-026-05918-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,28]]},"references-count":20,"alternative-id":["5918"],"URL":"https:\/\/doi.org\/10.1007\/s00266-026-05918-9","relation":{},"ISSN":["0364-216X","1432-5241"],"issn-type":[{"value":"0364-216X","type":"print"},{"value":"1432-5241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,28]]},"assertion":[{"value":"28 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All applicable institutional and\/or national guidelines for the care and use of animals were followed","order":2,"name":"Ethics","label":"Human and Animal Rights","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"For this type of study informed consent is not required.","order":3,"name":"Ethics","label":"Informed Consent","group":{"name":"EthicsHeading","label":"Declarations"}}]}}