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Elastic compression significantly attenuated this response, reducing leukocyte counts in subcutaneous lavage, histological inflammatory infiltrates, and the expression of key pro-inflammatory genes and proteins, including NF-\u03baB, IL-1\u03b2, and TNF-\u03b1, at both 24 and 72 hours post-induction. Mechanistically, these effects may result from the compressive force altering microvascular dynamics and modulating macrophage polarization and mechanotransduction pathways, including TLR4 and integrin signaling. Additionally, compression preserved redox homeostasis, as indicated by stable oxidative stress markers and antioxidant responses. To our knowledge, this is the first study to demonstrate that elastic compression modulates inflammation at molecular, cellular, and tissue levels in an acute inflammation model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>These findings support the therapeutic potential of elastic compression as a non-pharmacological strategy for managing acute inflammation, with possible applications in postoperative care, traumatic edema, and other soft tissue inflammatory conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Further translational and clinical studies are warranted to validate these outcomes and guide evidence-based application protocols.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>No Level Assigned<\/jats:title>\n                    <jats:p>\n                      This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.springer.com\/00266\" ext-link-type=\"uri\">www.springer.com\/00266<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00266-026-05983-0","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T16:08:23Z","timestamp":1782144503000},"page":"6419-6431","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Elastic Compression Attenuates Inflammatory Response in a Model of Acute Subcutaneous Abdominal Inflammation"],"prefix":"10.1007","volume":"50","author":[{"given":"Rubya Pereira","family":"Zaccaron","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina Borges","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ligia Milanez","family":"Venturini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"de Roch Casagrande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila","family":"da Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielli","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor Ramos","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolini","family":"Mendes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahisa","family":"Scussel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Andrez","family":"Machado-De-\u00c1vila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Thirupathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4908-2257","authenticated-orcid":false,"given":"Paulo Cesar Lock","family":"Silveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"5983_CR1","doi-asserted-by":"publisher","first-page":"2679","DOI":"10.2217\/nnm-2019-0119","volume":"14","author":"K Amin","year":"2019","unstructured":"Amin K, Moscalu R, Imere A, et al. 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All procedures were conducted in accordance with Brazilian legislation on the use of animals for scientific and educational purposes (Law 11.794, DOU 27\/05\/2013, MCTI, p. 7), and complied with the guidelines of the National Council for the Control of Animal Experimentation (Conselho Nacional de Controle de Experimenta\u00e7\u00e3o Animal\u2014CONCEA) and the National Commission for Animal Welfare (Comiss\u00e3o Nacional de Bem-Estar Animal\u2014COBEA). Additionally, all procedures adhered to the ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines.","order":2,"name":"Ethics","label":"Ethical Statement","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"In accordance with the ethical publication standards outlined by the Committee on Publication Ethics (COPE), we hereby declare that no generative artificial intelligence tools were used at any stage of the development of this manuscript, including writing, data analysis, interpretation, or image creation. All intellectual contributions are solely the work of the listed authors. The authors take full responsibility for the content and originality of this submission.","order":3,"name":"Ethics","label":"AI Use Declaration","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"As this is an experimental study conducted in an animal model, the classification by level of evidence is not applicable. This type of categorization is primarily intended for clinical studies involving human participants. Therefore, basic science, experimental research, animal studies, and cadaveric models do not require the assignment of an evidence level, in accordance with the principles of Evidence-Based Medicine.","order":4,"name":"Ethics","label":"Evidence-Based Medicine","group":{"name":"EthicsHeading","label":"Declarations"}}]}}