{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T15:16:08Z","timestamp":1788189368540,"version":"build-2803163510"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"16","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Aesth Plast Surg"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dermal fillers are widely utilized in esthetic medicine for soft tissue augmentation and facial rejuvenation. Generally safe, complications are mostly minor. Permanent complications, though rare, are disastrous and overwhelmingly caused by insufficient understanding of facial anatomy, wrong filler selection, technique, and poor diagnosis and management. This review aims to bridge the knowledge gaps that lead to permanent complications, provide guidelines to avoid them, and create best practices to manage them should they occur.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A PRISMA-guided systematic search of PubMed (2000\u20132024) was conducted using relevant search terms of English-language publications reporting irreversible outcomes or complications of fillers persisting beyond 12 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Blindness, stroke, chronic granulomatous inflammation, and irreversible tissue necrosis represent the most severe outcomes. The preponderance of evidence indicates that anatomic injection site, wrong technique, filler permanence, rather than injected volume alone, are the principal determinants of irreversible injury. HA fillers remain preferable due to reversibility; permanent fillers pose increased long-term complication risk. The following synthesis examines anatomically based injection safety principles, product selection criteria by location, and complication prevention strategies supported by peer-reviewed literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Safe and effective dermal filler practice is grounded in anatomic precision, meticulous technique, informed product selection, and preparedness to manage complications. Continuous education, adherence to evidence-based protocols, and awareness of high-risk anatomic regions could significantly reduce adverse outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence IV<\/jats:title>\n                    <jats:p>\n                      This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.springer.com\/00266\" ext-link-type=\"uri\">www.springer.com\/00266<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00266-026-05989-8","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T16:25:21Z","timestamp":1781540721000},"page":"6754-6764","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Permanent Complications After Dermal Fillers: Risks, Prevention, and Management Strategies"],"prefix":"10.1007","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0685-8022","authenticated-orcid":false,"given":"Simran K.","family":"Chandawarkar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Amjad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"key":"5989_CR1","unstructured":"Food and Drug Administration. 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