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This study assessed the efficacy and durability of associating abobotulinumtoxinA and Restylane\n                      <jats:sup>\u00ae<\/jats:sup>\n                      Skinbooster Vital for the treatment of canthal lines.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Twenty-four Brazilian women with dynamic periorbital wrinkles (Merz 5-point scale, levels II-IV) participated in this randomized, double-blinded, split-face trial. After bilateral abobotulinumtoxinA injections, one side of the face was randomized to receive Restylane\n                      <jats:sup>\u00ae<\/jats:sup>\n                      Skinbooster Vital, and the contralateral side underwent a simulated injection. Electromyography (EMG) activity, wrinkle severity, skin texture, and satisfaction with treatments were assessed at baseline and at 1, 2, 3, and 6 months. Data were analyzed using two-way repeated measures ANOVA, Bonferroni\u2019s post-hoc tests, and the Mann-Whitney U test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      EMG showed significant reductions over time, with no differences between treatments\u00a0protocols (\n                      <jats:italic>p<\/jats:italic>\n                      &gt; 0.05). For canthal wrinkle severity, the combined protocol (AbobotulinumtoxinA + Restylane\u00ae Skinbooster Vital) demonstrated lower scores at 3 months (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.0001) and 6 months (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.003) compared with AbobotulinumtoxinA alone, as reported by patients. Skin texture progressively improved following Restylane\u00ae Skinbooster Vital application, remaining significantly higher at 3 (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.0001) and 6 months (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.002) when compared with AbobotulinumtoxinA alone. Patient satisfaction increased in both protocols, with superior results at 3 months in the combined protocol group (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.009).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The association of abobotulinumtoxinA with Restylane\u00ae Skinbooster Vital provides enhanced and lasting improvements in severe canthal wrinkles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence I<\/jats:title>\n                    <jats:p>\n                      This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.springer.com\/00266\" ext-link-type=\"uri\">www.springer.com\/00266<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00266-026-06059-9","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T15:24:00Z","timestamp":1783524240000},"page":"7469-7479","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of AbobotulinumtoxinA and Skinbooster for Periorbital Wrinkles: A Randomized, Controlled, Double-Blind, Split-Face Study"],"prefix":"10.1007","volume":"50","author":[{"given":"Ana Claudia Laureano Navarro","family":"Shishido","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia Le\u00e3o Leite","family":"Tostes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryanne Brissian","family":"de Souza Nobre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline Rosa","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Alexandre","family":"de Sousa Mendes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Claudia","family":"Carbone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"S\u00e1nchez-Ayala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Barbosa","family":"C\u00e2mara-Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0921-342X","authenticated-orcid":false,"given":"Giancarlo","family":"De la Torre Canales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"issue":"3","key":"6059_CR1","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1080\/09546634.2020.1832189","volume":"33","author":"A Kolodziejczak","year":"2022","unstructured":"Kolodziejczak A, Rotsztejn H. 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The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The funder had no impact on the outcome of the clinical reports collection. The author A.C.C works as a speaker for Galderma, Brazil.\u00a0Livia Leao Leite Tostes works as a speaker for AbbVie (Allergan). Galderma\u00a0and AbbVie Brazil had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The company had no impact on the outcome of the study. All other authors declare no conflicts of interest.","order":1,"name":"Ethics","label":"Conflicts of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study protocol received ethical approval from the Research Ethics Committee of Uninga University (CAAE: 81365624.1.0000.5220) and adhered to the principles outlined in the Declaration of Helsinki. Written and signed informed consent was obtained from all participants prior to enrollment in the study and for the publication of any potentially identifiable images included in this article.","order":2,"name":"Ethics","label":"Ethical Approval","group":{"name":"EthicsHeading","label":"Declarations"}}]}}