{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:01:10Z","timestamp":1790186470528,"version":"4.1.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Aesth Plast Surg"],"DOI":"10.1007\/s00266-026-06261-9","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:08:26Z","timestamp":1790183306000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Efficacy of 595-nm Pulsed Dye Laser versus CO2 Fractional Laser in the Treatment of Scars Following Cleft Lip Repair"],"prefix":"10.1007","author":[{"given":"Haoshu","family":"Chi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubo","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyue","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"issue":"2","key":"6261_CR1","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.jormas.2021.05.008","volume":"123","author":"N Salari","year":"2022","unstructured":"Salari N, Darvishi N, Heydari M, et al. Global prevalence of cleft palate, cleft lip and cleft palate and lip: a comprehensive systematic review and meta-analysis. J Stomatol Oral Maxillofac Surg. 2022;123(2):110\u201320.","journal-title":"J Stomatol Oral Maxillofac Surg"},{"issue":"2","key":"6261_CR2","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/S0094-1298(03)00133-0","volume":"31","author":"M Cohen","year":"2004","unstructured":"Cohen M. Residual deformities after repair of clefts of the lip and palate. Clin Plast Surg. 2004;31(2):331\u201345.","journal-title":"Clin Plast Surg"},{"issue":"2","key":"6261_CR3","doi-asserted-by":"publisher","first-page":"e15","DOI":"10.1597\/15-095","volume":"54","author":"PC Aravena","year":"2017","unstructured":"Aravena PC, Gonzalez T, Oyarz\u00fan T, et al. Oral health-related quality of life in children in Chile treated for cleft lip and palate: a case-control approach. Cleft Palate Craniofac J. 2017;54(2):e15\u201320.","journal-title":"Cleft Palate Craniofac J"},{"issue":"7-8","key":"6261_CR4","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1080\/14764172.2018.1461230","volume":"20","author":"NS Sadick","year":"2018","unstructured":"Sadick NS, Cardona A. Laser treatment for facial acne scars: a review. J Cosmet Laser Ther. 2018;20(7\u20138):424\u201335.","journal-title":"J Cosmet Laser Ther"},{"issue":"1","key":"6261_CR5","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14539","volume":"34","author":"DD Zhang","year":"2021","unstructured":"Zhang DD, Zhao WY, Fang QQ, et al. The efficacy of fractional CO2\u00a0laser in acne scar treatment: a meta-analysis. Dermatol Ther. 2021;34(1):e14539.","journal-title":"Dermatol Ther"},{"issue":"4","key":"6261_CR6","doi-asserted-by":"publisher","first-page":"208","DOI":"10.3109\/14764172.2015.1114648","volume":"18","author":"A-S Al-Mohamady","year":"2016","unstructured":"Al-Mohamady A-S, Ibrahim SM, et al. Pulsed dye laser versus long-pulsed Nd:YAG laser in the treatment of hypertrophic scars and keloid: a comparative randomized split-scar trial. J Cosmet Laser Ther. 2016;18(4):208\u201312.","journal-title":"J Cosmet Laser Ther"},{"issue":"6","key":"6261_CR7","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1089\/wound.2023.0106","volume":"13","author":"H Chi","year":"2024","unstructured":"Chi H, Peng H, Zhao X, et al. The effectiveness of 595-nm pulsed dye laser for the treatment of bilateral cleft-lip scars in Asian patients: a 6-month prospective, randomized, self-controlled trial. Adv Wound Care New Rochelle. 2024;13(6):322\u20138.","journal-title":"Adv Wound Care New Rochelle"},{"issue":"2","key":"6261_CR8","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1097\/DSS.0000000000003688","volume":"49","author":"H Chi","year":"2023","unstructured":"Chi H, Zhao X, Shen L, et al. Optimal timing of fractional CO2 laser on cleft lip scars: a single-blind randomized controlled cohort study. Dermatol Surg. 2023;49(2):145\u20138.","journal-title":"Dermatol Surg"},{"issue":"4","key":"6261_CR9","first-page":"238","volume":"67","author":"D Elliot","year":"1985","unstructured":"Elliot D, Cory-Pearce R, Rees GM. The behaviour of presternal scars in a fair-skinned population. Ann R Coll Surg Engl. 1985;67(4):238\u201340.","journal-title":"Ann R Coll Surg Engl"},{"issue":"3","key":"6261_CR10","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/0305-4179(90)90033-S","volume":"16","author":"WH Lewis","year":"1990","unstructured":"Lewis WH, Sun KK. Hypertrophic scar: a genetic hypothesis. Burns. 1990;16(3):176\u20138.","journal-title":"Burns"},{"issue":"2","key":"6261_CR11","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1002\/lsm.1035","volume":"28","author":"A Capon","year":"2001","unstructured":"Capon A, Souil E, Gauthier B, et al. Laser assisted skin closure (LASC) by using a 815-nm diode-laser system accelerates and improves wound healing. Lasers Surg Med. 2001;28(2):168\u201375.","journal-title":"Lasers Surg Med"},{"issue":"2","key":"6261_CR12","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1080\/14764172.2017.1358452","volume":"20","author":"F Du","year":"2018","unstructured":"Du F, Yu Y, Zhou Z, et al. Early treatment using fractional CO2 laser before skin suture during scar revision surgery in Asians. J Cosmet Laser Ther. 2018;20(2):102\u20135.","journal-title":"J Cosmet Laser Ther"},{"issue":"2","key":"6261_CR13","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1097\/00006534-200208000-00031","volume":"110","author":"TA Mustoe","year":"2002","unstructured":"Mustoe TA, Cooter RD, Gold MH, et al. International clinical recommendations on scar management. Plast Reconstr Surg. 2002;110(2):560\u201371.","journal-title":"Plast Reconstr Surg"},{"issue":"2","key":"6261_CR14","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1001\/jamadermatol.2013.7761","volume":"150","author":"RR Anderson","year":"2014","unstructured":"Anderson RR, Donelan MB, Hivnor C, et al. Laser treatment of traumatic scars with an emphasis on ablative fractional laser resurfacing: consensus report. JAMA Dermatol. 2014;150(2):187\u201393.","journal-title":"JAMA Dermatol"},{"issue":"20","key":"6261_CR15","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1097\/CM9.0000000000000467","volume":"132","author":"H Cai","year":"2019","unstructured":"Cai H, Liu Y, Zhang L, et al. Multi-wavelength laser treatments of spider nevi. Chin Med J. 2019;132(20):2417\u201322.","journal-title":"Chin Med J"},{"key":"6261_CR16","doi-asserted-by":"publisher","DOI":"10.5978\/islsm.14-re-01","author":"T Omi","year":"2025","unstructured":"Omi T, Numano K. The role of the CO2 laser and fractional CO2 laser in dermatology. Lasers Med Sci. 2025. https:\/\/doi.org\/10.5978\/islsm.14-re-01.","journal-title":"Lasers Med Sci"},{"issue":"20","key":"6261_CR17","doi-asserted-by":"publisher","first-page":"2417","DOI":"10.1097\/CM9.0000000000000467","volume":"132","author":"C Zhang","year":"2019","unstructured":"Zhang C, Ge HS, Yang S, Zhang XJ. Clinical efficacy of 595-nm pulsed-dye laser in treatment of childhood facial spider nevi: a retrospective study of 110 patients. Chin Med J (Engl). 2019;132(20):2417\u201322.","journal-title":"Chin Med J (Engl)"},{"issue":"1","key":"6261_CR18","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-024-04230-9","volume":"40","author":"LTT H\u1ea3i","year":"2025","unstructured":"H\u1ea3i LTT, Ph\u01b0\u01a1ng BTT, Minh PN, Firas AN. Efficacy of the 595 nm pulsed dye laser in the treatment of hemangiomas in Vietnamese patients. Lasers Med Sci. 2025;40(1):41.","journal-title":"Lasers Med Sci"},{"key":"6261_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.156498","volume":"140","author":"RY Shang","year":"2025","unstructured":"Shang RY, Yang JC, Hu WG, et al. Artesunate attenuates skin hypertrophic scar formation by inhibiting fibroblast activation and EndMT of vascular endothelial cells. Phytomedicine. 2025;140:156498.","journal-title":"Phytomedicine"},{"issue":"1","key":"6261_CR20","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-16376-z","volume":"12","author":"EA Molina","year":"2022","unstructured":"Molina EA, Hartmann B, Oliver MA, et al. Angiogenic gene characterization and vessel permeability of dermal microvascular endothelial cells isolated from burn hypertrophic scar. Sci Rep. 2022;12(1):12222.","journal-title":"Sci Rep"},{"issue":"2","key":"6261_CR21","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10630","volume":"9","author":"Y Tan","year":"2023","unstructured":"Tan Y, Zhang M, Kong Y, et al. Fibroblasts and endothelial cells interplay drives hypertrophic scar formation: Insights from in vitro and in vivo models. Bioeng Transl Med. 2023;9(2):e10630.","journal-title":"Bioeng Transl Med."},{"key":"6261_CR22","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1007\/0-387-30128-3_11","volume":"557","author":"S Hermanns","year":"2006","unstructured":"Hermanns S, Klapka N, Gasis M, et al. The collagenous wound healing scar in the injured central nervous system inhibits axonal regeneration. Adv Exp Med Biol. 2006;557:177\u201390.","journal-title":"Adv Exp Med Biol"},{"issue":"4","key":"6261_CR23","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3109\/14764172.2014.1003242","volume":"17","author":"Q Su","year":"2015","unstructured":"Su Q, Lin T, Wu Q, et al. Efficacy of 595nm pulsed dye laser therapy for Mibelli angiokeratoma. J Cosmet Laser Ther. 2015;17(4):209\u201312.","journal-title":"J Cosmet Laser Ther"},{"issue":"7","key":"6261_CR24","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1080\/09546634.2019.1704679","volume":"32","author":"C Zhang","year":"2021","unstructured":"Zhang C, Yin K, Shen YM. Efficacy of fractional carbon dioxide laser therapy for burn scars: a meta-analysis. J Dermatolog Treat. 2021;32(7):845\u201350.","journal-title":"J Dermatolog Treat"},{"issue":"1","key":"6261_CR25","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1097\/BOR.0b013e32835b13b6","volume":"25","author":"LA DiPietro","year":"2013","unstructured":"DiPietro LA. Angiogenesis and scar formation in healing wounds. Curr Opin Rheumatol. 2013;25(1):87\u201391.","journal-title":"Curr Opin Rheumatol"}],"container-title":["Aesthetic Plastic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00266-026-06261-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00266-026-06261-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00266-026-06261-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:08:27Z","timestamp":1790183307000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00266-026-06261-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,23]]},"references-count":25,"alternative-id":["6261"],"URL":"https:\/\/doi.org\/10.1007\/s00266-026-06261-9","relation":{},"ISSN":["0364-216X","1432-5241"],"issn-type":[{"value":"0364-216X","type":"print"},{"value":"1432-5241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,23]]},"assertion":[{"value":"16 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"No conflict of interest exits in the submission of this manuscript, and it is approved by all authors for publication. This manuscript has not been published and is not under consideration for publication elsewhere.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study protocol was approved by the Research Ethical Review Committee of Shanghai Ninth People\u2019s Hospital (SH9H-2023-T473\u20132).","order":2,"name":"Ethics","label":"Ethical Approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The written informed consent was obtained from all participants (or their guardians).","order":3,"name":"Ethics","label":"Informed Consent","group":{"name":"EthicsHeading","label":"Declarations"}}]}}