{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:43:44Z","timestamp":1792683824287,"version":"4.5.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100009754","name":"Galderma","doi-asserted-by":"publisher","award":["10842601"],"award-info":[{"award-number":["10842601"]}],"id":[{"id":"10.13039\/501100009754","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Aesth Plast Surg"],"abstract":"Abstract<\/jats:title>\n \n Introduction<\/jats:title>\n This study aimed to evaluate the efficacy of fan-shaped poly-L-lactic acid (PLLA) injections for facial lifting in Asian patients using quantitative measurements.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Twelve Asian participants aged 18\u201350 years were enrolled in this prospective, open-label study. PLLA (Sculptra\u00ae, Galderma) was injected with blunt cannulas at two key anatomical sites: the temporal region (targeting the sub-superficial fascia) and the buccal region (above the SMAS layer near the anterior border of the masseter). Injections were administered in a retrograde, fan-shaped pattern. Facial assessments were performed at baseline and at weeks 4, 12, and 24 using 4-angle and 6-length measurements via the OBSERV\u00ae A+ skin analysis system. Participant satisfaction was also evaluated.<\/jats:p>\n <\/jats:sec>\n \n Result<\/jats:title>\n At week 24, the tragus\u2013oral commissure length shortened from 221.17\u2009\u00b1\u200916.90\u00a0mm to 209.14\u2009\u00b1\u200910.14 mm (p\u2009<\u20090.05), while the lower facial contour length was reduced from 264.83\u2009\u00b1\u200918.04\u00a0mm to 251.93\u2009\u00b1\u200912.21\u00a0mm (p\u2009<\u20090.05). Both measurements showed earlier significance at week 12(p\u2009<\u20090.01). In the upper face, the eyebrow peak angle rose from 21.79\u2009\u00b1\u20093.75\u00b0 to 24.02\u2009\u00b1\u20094.92\u00b0 at week 24 (p\u2009<\u20090.05), and the vertical palpebral fissure length increased from 9.92\u2009\u00b1\u20091.27\u00a0mm to 10.42\u2009\u00b1\u20091.05 mm at week 24(p\u2009<\u20090.05). The canthus\u2013oral\u2013nasal angle showed a transient increase at week 4 (37.8\u2009\u00b1\u20096.1\u00b0 to 41.64\u2009\u00b1\u20094.26\u00b0, p\u2009<\u20090.05) but was not sustained thereafter. No serious adverse events were observed, and patient satisfaction remained consistently high throughout the study period.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Fan-shaped PLLA injections are a minimally invasive, well-tolerated, and effective approach to facial rejuvenation in Asian patients, yielding measurable improvements in periorbital features and sustained contour enhancement in the mid- and lower face.<\/jats:p>\n <\/jats:sec>\n \n Level of Evidence II<\/jats:title>\n \n This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors\n www.springer.com\/00266<\/jats:ext-link>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Important Points<\/jats:title>\n \n \n \n Fan-shaped PLLA injections provide a safe, minimally invasive option for mid- and lower-face rejuvenation, especially suitable for Asian patients.<\/jats:p>\n <\/jats:list-item>\n \n Facial contour improvements, including reduced tragus\u2013oral and lower facial lengths, are maintained for up to 24 weeks.<\/jats:p>\n <\/jats:list-item>\n \n Although upper facial effects were less sustained, combining Fan-shaped PLLA injections with collagen-stimulating agents like hyaluronic acid may enhance and prolong results.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1007\/s00266-026-06346-5","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:12:17Z","timestamp":1792681937000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Prospective Cohort Study Demonstrating Measurable Facial Lifting with Fan-Shaped Poly-L-Lactic Acid Injections in Asian Patients"],"prefix":"10.1007","author":[{"given":"Pei-Hsuan","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Han","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0463-7346","authenticated-orcid":false,"given":"Chang-Cheng","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung-Hsueh","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Chuan","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,22]]},"reference":[{"key":"6346_CR1","doi-asserted-by":"publisher","first-page":"e3219","DOI":"10.1097\/GOX.0000000000003219","volume":"8","author":"HJ Moon","year":"2020","unstructured":"Moon HJ, Gao ZW, Hu ZQ, Wang H, Wang XJ. 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The study was designed, analyzed, and interpreted independently by the academic authors with no influence from the sponsor. Data are available upon reasonable request from the corresponding author. Author Chang-Cheng Chang has received research grants from Galderma S.A. (Grant No.10842601). Other authors declare that they have no conflict of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures performed in studies involving human participants were conducted in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.","order":2,"name":"Ethics","label":"Statement of Human and Rights","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This research was approved by the institutional review board of China Medical University Hospital in Taichung (CMUH113-REC2-025).","order":3,"name":"Ethics","label":"Compliance with Ethical Standards","group":{"name":"EthicsHeading","label":"Declarations"}}]}}