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During the preparation of this work, the authors, whose first language is not English, used artificial intelligence (AI)-assisted tools for language editing and readability enhancement. After using these tools, the authors reviewed and edited the content as needed and took full responsibility for the final version of the manuscript.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal procedures were performed in accordance with the US Public Health Service Policy on Humane Care and Use of Laboratory Animals and were approved by the relevant Animal Experiments Local Ethics Committee (Approval Date: 01.02.2021, Approval No: 5). The study adhered to both institutional and international ethical guidelines for animal research. Furthermore, the study was conducted and reported in compliance with the ARRIVE 2.0 guidelines (Animal Research: Reporting of In Vivo Experiments) to ensure transparency and reproducibility.","order":2,"name":"Ethics","label":"Ethical Approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"For this type of study, informed consent is not required.","order":3,"name":"Ethics","label":"Informed Consent","group":{"name":"EthicsHeading","label":"Declarations"}}]}}