{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T22:45:25Z","timestamp":1777329925555,"version":"3.51.4"},"reference-count":0,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,2,20]],"date-time":"2014-02-20T00:00:00Z","timestamp":1392854400000},"content-version":"vor","delay-in-days":4647,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2001,6]]},"abstract":"<jats:title>Abstract.<\/jats:title><jats:p>In patients with differentiated thyroid cancer (DTC) total or near\u2010total thyroidectomy, postoperative <jats:sup>131<\/jats:sup>I ablation, and thyroid suppression therapy are reported to be associated with fewer recurrences than other treatments. Many patients with DTC after total thyroidectomy and radioablation therapy have diffuse hepatic uptake of radioiodine, and its clinical importance is debated. Some investigators report that diffuse liver uptake correlates with uptake in the thyroid bed or the presence of metastatic thyroid cancer somewhere in the body, whereas others note no such correlation. The purpose of this research was to determine the clinical importance of diffuse hepatic uptake of radioiodine after <jats:sup>131<\/jats:sup>I ablative therapy in patients with DTC. We retrospectively reviewed 141 posttherapy scans done in 118 patients with DTC. Patients had had total thyroidectomy and were hypothyroid when serum thyroglobulin (Tg) levels were obtained, and they were treated with 30 to 200\u00a0mCi of <jats:sup>131<\/jats:sup>I. Scans were performed 3 to 21\u00a0days after radioablation therapy. Information was collected regarding the patients' age and gender, the interval between the ablation therapy and scan, uptake of radioiodine, serum thyroglobulin level, thyroid\u2010stimulating hormone (TSH) level, thyroglobulin antibodies, TNM classification, mortality, and recurrence. Diffuse liver uptake was classified from 0 to 4 depending on hepatic brightness. Radioiodine scans were done to determine whether there was uptake in the thyroid bed or elsewhere. Statistical analyses included analysis of variance and Kaplan\u2010Meier survival analysis. Diffuse hepatic uptake was observed (grades 1\u20134) in 96.4% of the patients; thus 3.6% had no hepatic uptake. There was no significant association between liver uptake and the uptake in the thyroid bed, the dose of <jats:sup>131<\/jats:sup>I administered for ablation therapy, thyroglobulin levels, age, stage of the disease, presence of local or distant metastases, recurrence, or survival. Diffuse hepatic uptake was therefore not associated with residual normal thyroid or metastases as suggested by some but not all previous investigators.<\/jats:p>","DOI":"10.1007\/s00268-001-0021-8","type":"journal-article","created":{"date-parts":[[2003,10,27]],"date-time":"2003-10-27T18:06:14Z","timestamp":1067277974000},"page":"718-722","source":"Crossref","is-referenced-by-count":19,"title":["Association between Residual Thyroid Carcinoma and Diffuse Hepatic Uptake of <sup>131<\/sup>I following Radioiodine Ablation in Postoperative Total Thyroidectomy Patients"],"prefix":"10.1002","volume":"25","author":[{"given":"Fatma Atalay","family":"Tatar","sequence":"first","affiliation":[{"name":"Department of Surgery University of California San Francisco\/Mount Zion Medical Center 1600 Divisadero Street, Room C347 San Francisco, California 94143\u20101674 USA<!--<country1>US<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugene","family":"Morita","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University of California San Francisco\/Mount Zion Medical Center 1600 Divisadero Street San Francisco, California 94143 USA<!--<country1>US<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip H.G.","family":"Ituarte","sequence":"additional","affiliation":[{"name":"Department of Surgery University of California San Francisco\/Mount Zion Medical Center 1600 Divisadero Street, Room C347 San Francisco, California 94143\u20101674 USA<!--<country1>US<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph R.","family":"Cavalieri","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Veterans Affairs Medical Center 4150 Clement Street, San Francisco California 94121 USA<!--<country1>US<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quan\u2010Yang","family":"Duh","sequence":"additional","affiliation":[{"name":"Surgical Service Veterans Affairs Medical Center 4150 Clement Street, San Francisco, California 94121 USA<!--<country1>US<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David C.","family":"Price","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nuclear Medicine Program The Medical Center at the University of California San Francisco, Room L\u2010340 San Francisco California 94143\u20100252 USA<!--<country1>US<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allan E.","family":"Siperstein","sequence":"additional","affiliation":[{"name":"Department of Surgery University of California San Francisco\/Mount Zion Medical Center 1600 Divisadero Street, Room C347 San Francisco, California 94143\u20101674 USA<!--<country1>US<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orlo H.","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Surgery University of California San Francisco\/Mount Zion Medical Center 1600 Divisadero Street, Room C347 San Francisco, California 94143\u20101674 USA<!--<country1>US<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,20]]},"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-001-0021-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-001-0021-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-001-0021-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T20:24:05Z","timestamp":1705004645000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-001-0021-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,6]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2001,6]]}},"alternative-id":["10.1007\/s00268-001-0021-8"],"URL":"https:\/\/doi.org\/10.1007\/s00268-001-0021-8","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,6]]}}}