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More than half of the patients with primary aldosteronism detected in this way have normal circulating potassium levels, so measurement of potassium is not enough to exclude primary aldosteronism. When primary aldosteronism is diagnosed, fewer than one\u2010third of patients are suitable for surgery as initial treatment, but this still represents a significant percentage of hypertensive patients. After excluding glucocorticoid\u2010suppressible primary aldosteronism, adrenal venous sampling is essential to detect unilateral production of aldosterone and diagnose angiotensin\u2010responsive aldosterone\u2010producing adenoma. One cannot rely on the computed tomography scan. If all hypertensive patients are screened for primary aldosteronism and the workup is continued methodically in those with a positive screening test, patients with unilateral overproduction of aldosterone who potentially can be cured surgically are not denied the possibility of cure.<\/jats:p>","DOI":"10.1007\/s00268-001-0033-4","type":"journal-article","created":{"date-parts":[[2003,10,27]],"date-time":"2003-10-27T18:08:51Z","timestamp":1067278131000},"page":"941-947","source":"Crossref","is-referenced-by-count":78,"title":["Primary aldosteronism: Are we diagnosing and operating on too few patients?"],"prefix":"10.1002","volume":"25","author":[{"given":"Richard D.","family":"Gordon","sequence":"first","affiliation":[{"name":"Endocrine\u2010Hypertension Research Unit University of Queensland Department of Medicine Greenslopes Hospital 4120 Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Stowasser","sequence":"additional","affiliation":[{"name":"Endocrine\u2010Hypertension Research Unit University of Queensland Department of Medicine Greenslopes Hospital 4120 Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Rutherford","sequence":"additional","affiliation":[{"name":"Endocrine\u2010Hypertension Research Unit University of Queensland Department of Medicine Greenslopes Hospital 4120 Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,7]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"6","article-title":"Primary aldosteronism, a new clinical syndrome","volume":"45","author":"Conn J.W.","year":"1955","journal-title":"J. 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