{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:54:44Z","timestamp":1792148084974,"version":"4.4.0"},"reference-count":12,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2001,7,1]],"date-time":"2001-07-01T00:00:00Z","timestamp":993945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2001,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Laparoscopic splenectomy (LS) is an alternative to open surgery. However, there is a theoretic risk of splenosis and abdominal cavity dissemination of splenic cells if the splenic capsule is broken, as seen by experimental evidence of tumoral cell mobilization by the pneumoperitoneum. We evaluated the features of splenosis after splenectomy operated via an open approach or under laparoscopic control in an experimental model in the rat. A total of 65 Sprague\u2010Dawley rats were distributed in seven groups that included the open approach, CO<jats:sub>2<\/jats:sub> pneumoperitoneum LS, or wall lift LS with or without a splenic graft. Splenic function was evaluated 90\u00a0day later through (1) scintigraphy with Tc\u2010labeled heat\u2010damaged erythrocytes; (2) determination of circulating \u201cpitted\u201d cells; and (3) analysis of the distribution of splenic pulp in the peritoneal cavity. Scintigraphy did not show viable residual tissue in any group after splenectomy; splenic activity in the splenic fossa was observed in 40% of the animals with grafts. Splenectomy increased the \u201cpit\u201d cell count, but it was reduced to normal values with a splenic graft. Necropsy showed normal splenic tissue in the splenic fossa in 100% of animals with a graft. Abdominal implants were observed significantly more frequently after CO<jats:sub>2<\/jats:sub> LS than after the open surgery or a wall lift LS (80% vs. 20% vs. 30%; <jats:italic>p<\/jats:italic>&lt;0.05). In addition, trocar site implants were observed with CO<jats:sub>2<\/jats:sub> LS (<jats:italic>n<\/jats:italic>=3) or wall lift LS (<jats:italic>n<\/jats:italic>=2), whereas there were no implants in the wound in the open group. We conclude that in an experimental rat model the pneumoperitoneum may facilitate abdominal splenosis after LS if the splenic capsule is ruptured or if splenic tissue spills compared with surgery without gas (open or laparoscopic).<\/jats:p>","DOI":"10.1007\/s00268-001-0045-0","type":"journal-article","created":{"date-parts":[[2003,10,27]],"date-time":"2003-10-27T18:08:51Z","timestamp":1067278131000},"page":"882-885","source":"Crossref","is-referenced-by-count":18,"title":["Evaluation of risk of splenosis during laparoscopic splenectomy in rat model"],"prefix":"10.1002","volume":"25","author":[{"given":"Joan Josep","family":"Espert","sequence":"first","affiliation":[{"name":"Service of General and Digestive Surgery Hospital Clinic Villarroel 170 08036 Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduard M.","family":"Targarona","sequence":"additional","affiliation":[{"name":"Service of General and Digestive Surgery Hospital Clinic Villarroel 170 08036 Barcelona Spain"},{"name":"Service of General and Digestive Surgery Hospital de Sant Pau Avenida P. Claret 165 08025 Barcelona Spain"},{"name":"Service of Nuclear Medicine Hospital Clinic Villarroel 170 08036 Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernest","family":"Bombuy","sequence":"additional","affiliation":[{"name":"Service of General and Digestive Surgery Hospital Clinic Villarroel 170 08036 Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Setoain","sequence":"additional","affiliation":[{"name":"Service of General and Digestive Surgery Hospital de la Santa Creu i Sant Pau Sant Antoni M. Claret 167 08025 Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Visa","sequence":"additional","affiliation":[{"name":"Service of General and Digestive Surgery Hospital Clinic Villarroel 170 08036 Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Trias","sequence":"additional","affiliation":[{"name":"Service of General and Digestive Surgery Hospital de Sant Pau Avenida P. Claret 165 08025 Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019509\u2010199901000\u201000001"},{"key":"e_1_2_1_3_1","first-page":"147","article-title":"Present status of laparoscopic splenectomy for hematological diseases: certitudes and unresolved issues","volume":"5","author":"Gigot J.F.","year":"1998","journal-title":"Semin Laparosc. 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