{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T07:14:11Z","timestamp":1783581251690,"version":"3.55.0"},"reference-count":0,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2001,7,9]],"date-time":"2001-07-09T00:00:00Z","timestamp":994636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2001,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Preoperative irradiation has been used to produce tumor regression and allow complete resection of rectal cancer with a sphincter\u2010saving procedure. To evaluate the associated toxicity, the response in the primary tumor, and the postsurgical morbidity in a group of patients with locally advanced rectal cancer treated with preoperative chemoradiation therapy and low anterior resection, 120 patients were treated with 45\u00a0Gy of preoperative radiotherapy and a bolus infusion of 5\u2010fluorouracil 450\u00a0mg\/m<jats:sup>2<\/jats:sup> on days 1 to 5 and 28 to 32 of radiotherapy. Four to six weeks later, 16 lesions were found unresectable; 36 patients underwent abdominoperineal resection or pelvic exenteration, and in the remaining 68 a low anterior resection was performed. For the purpose of this study only the latter group was included. There were 38\u00a0men and 30 women, with a mean age of 54.7 \u00b1 13.1 years. Gastrointestinal and hematologic acute toxicity grade 3 to 4 occurred in 12 and 7 patients, respectively. The mean distance of the tumor above the anal verge was 8.2 \u00b1 2.6\u00a0cm. In 10 patients the surgical resection included neighboring pelvic organs; 16 patients (23.5%) required a temporary diverting colostomy. The main causes of surgical morbidity were clinical anastomotic leakage in seven (10%), abdominal wall infection in five (7.4%), anastomotic stenosis in three (4.5%), and intraabdominal abscess in one (1.5%). No operative deaths occurred. The postsurgical stages were as follows: no tumor in the specimen, 17 (25%); T1, 4 (6%); T2, 12 (17%); T3, 17 (25%); T4, 5 (7%); any T with N+, 9 (13%); and any T, N with M+, 4 (6%). The median and mean follow\u2010ups were 30.0\u00a0months and 37.4 \u00b1 25.0\u00a0months, respectively. The local recurrence rate was 2.9%, and the distant recurrence rate was 17%. The administration of preoperative chemoradiation therapy for locally advanced rectal cancer is associated with tolerable toxicity, a high rate of response in the primary tumor that allowed anal sphincter preservation, and a low rate of local recurrence.<\/jats:p>","DOI":"10.1007\/s00268-001-0071-y","type":"journal-article","created":{"date-parts":[[2003,10,27]],"date-time":"2003-10-27T18:08:51Z","timestamp":1067278131000},"page":"1006-1011","source":"Crossref","is-referenced-by-count":34,"title":["Preoperative Chemoradiation Therapy and Anal Sphincter Preservation with Locally Advanced Rectal Adenocarcinoma"],"prefix":"10.1002","volume":"25","author":[{"given":"Pedro","family":"Luna\u2010P\u00e9rez","sequence":"first","affiliation":[{"name":"Colorectal Service Surgical Oncology Department Hospital de Oncolog\u00eda, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social Avenida Cuauht\u00e9moc 330, Colonia Doctores, CP 06720, M\u00e9xico, D.F. M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sa\u00fal","family":"Rodr\u00edguez\u2010Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Colorectal Service Surgical Oncology Department Hospital de Oncolog\u00eda, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social Avenida Cuauht\u00e9moc 330, Colonia Doctores, CP 06720, M\u00e9xico, D.F. M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dar\u00edo F.","family":"Rodriguez\u2010Coria","sequence":"additional","affiliation":[{"name":"Colorectal Service Surgical Oncology Department Hospital de Oncolog\u00eda, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social Avenida Cuauht\u00e9moc 330, Colonia Doctores, CP 06720, M\u00e9xico, D.F. M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Radiotherapy Department, Hospital de Oncolog\u00eda, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social Avenida Cuauht\u00e9moc 330, Colonia Doctores, CP 06720, M\u00e9xico, D.F. M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Labastida","sequence":"additional","affiliation":[{"name":"Statistical Section Hospital de Oncolog\u00eda, Centro M\u00e9dico Nacional Siglo XXI Instituto Mexicano del Seguro Social Avenida Cuauht\u00e9moc 330, Colonia Doctores, CP 06720 M\u00e9xico, D.F. M\u00e9xico<!--<country1>Mexico<\/country1>-->"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Silva","sequence":"additional","affiliation":[{"name":"Medical Oncology Department Hospital de Oncolog\u00eda Centro M\u00e9dico Nacional Siglo XXI Instituto Mexicano del Seguro Social Avenida Cuauht\u00e9moc 330, Colonia Doctores, CP 06720 M\u00e9xico, D.F., M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marvin J.","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Department of Surgery St. Elizabeth's Medical Center of Boston Tufts University School of Medicine 736 Cambridge Street, CMP1, Boston Massachusetts 02135 USA<!--<country1>USA<\/country1>-->"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,7,9]]},"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-001-0071-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-001-0071-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-001-0071-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T19:42:29Z","timestamp":1705002149000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-001-0071-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,7,9]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2001,8]]}},"alternative-id":["10.1007\/s00268-001-0071-y"],"URL":"https:\/\/doi.org\/10.1007\/s00268-001-0071-y","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,7,9]]}}}