{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:44:50Z","timestamp":1761518690495},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2002,6,1]],"date-time":"2002-06-01T00:00:00Z","timestamp":1022889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2002,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Elevated serum concentrations of 1\u201384 parathyroid hormone (PTH) after operation for sporadic parathyroid adenoma have been re\u2010ported in previous studies, years after operation for primary hyperparathyroidism (pHPT). The cause and significance of this finding have not been elucidated. Primary hyperparathyroidism was diagnosed in 195 patients from January 1987 to December 1998. Operation for pHPT was performed in 124 patients. To evaluate long\u2010term effects of elevated serum 1\u201384\u00a0PTH, biochemical variables and pre\u2010 and postoperative diseases were investigated from hospital case records. Of the 124 patients operated on, 103 had a solitary adenoma. Among these patients, 60 had normal serum concentrations of 1\u201384\u00a0PTH and calcium postoperatively, 38 patients had follow\u2010up for more than 12\u00a0months (range 12\u2013207\u00a0months\u2014group A). Persistent elevated serum concentrations of 1\u201384\u00a0PTH and normocalcemia were found in 23 patients. Fourteen patients had follow\u2010up for more than 12\u00a0months (range 15\u201376\u00a0months\u2014group B). Two patients had persistent pHPT, and 18 were normocalcemic, but in this retrospective study data on serum 1\u201384\u00a0PTH were not available. No significant differences were found between groups A and B at the time of diagnosis concerning clinical characteristics. More that 12\u00a0months after operation for pHPT, the patients in group B, with persistent elevated serum concentrations of 1\u201384\u00a0PTH, had a significantly (<jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>=11, <jats:italic>p<\/jats:italic>=0.005, and power of test 0.66) higher frequency of cardiovascular diseases from isch\u00e9mie heart disease and hypertension. Persistent elevated serum concentrations of 1\u201384\u00a0PTH after operation for sporadic parathyroid adenoma may be associated with development of cardiovascular disease. This group of patients therefore needs lifelong control and, possibly, medical intervention.<\/jats:p>","DOI":"10.1007\/s00268-001-0285-z","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T13:47:51Z","timestamp":1033912071000},"page":"657-660","source":"Crossref","is-referenced-by-count":21,"title":["Normocalcemia and persistent elevated serum concentrations of 1\u201384 parathyroid hormone after operation for sporadic parathyroid adenoma: evidence of increased morbidity from cardiovascular disease"],"prefix":"10.1002","volume":"26","author":[{"given":"Henrik","family":"Vestergaard","sequence":"first","affiliation":[{"name":"Department of Endocrinology Herlev Hospital University of Copenhagen DK\u20102730 Herlev Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars \u00d8stergaard","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Herlev Hospital University of Copenhagen DK\u20102730 Herlev Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,6]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"1021","article-title":"Parathyroid hormone: before and after parathyroidectomy","volume":"100","author":"Duh Q\u2010Y","year":"1986","journal-title":"Surgery"},{"key":"e_1_2_1_3_1","first-page":"898","article-title":"Parathyroid metabolism after operative treatment of hypercalcemic (primary) hyperparathyroidism","volume":"102","author":"Irvin GL","year":"1987","journal-title":"Surgery"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039\u20106060(96)80186\u20103"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.45.609"},{"key":"e_1_2_1_6_1","first-page":"1123","article-title":"Long\u2010term effects of parathyroid operation on serum calcium and parathyroid hormone values in sporadic primary hyperparathyroidism","volume":"112","author":"Lundgren E","year":"1992","journal-title":"Surgery"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650061423"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.82.1.106"},{"key":"e_1_2_1_9_1","first-page":"455","volume-title":"Practical Statistics for Medical Research","author":"Altman DG","year":"1991"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01658740"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102362.1998.00289.x"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.54.5.539"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895\u20104356(97)00104\u20102"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102265.1999.00651.x"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3100439"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110299"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1994.148"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.4.1598"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1997.41"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-001-0285-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-001-0285-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-001-0285-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T20:13:55Z","timestamp":1705004035000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-001-0285-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,6]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2002,6]]}},"alternative-id":["10.1007\/s00268-001-0285-z"],"URL":"https:\/\/doi.org\/10.1007\/s00268-001-0285-z","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,6]]}}}