{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:57:00Z","timestamp":1792097820296,"version":"4.4.0"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2002,11,1]],"date-time":"2002-11-01T00:00:00Z","timestamp":1036108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2002,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In Western experience, the long\u2010term survival benefit after extended pancreaticoduodenectomy (EPD) in patients with pancreatic ductal adenocarcinoma is still controversial. The aim of this work was to evaluate weather EPD for pancreatic ductal adenocarcinoma prolongs long\u2010term survival compared to standard pancreaticoduodenectomy (SPD). From November 1992 to September 1996, we performed pancreatic resections in 30 patients affected by stage I\u2013III pancreatic ductal adenocarcinoma: 13 patients underwent SPD and 17 patients underwent EPD, consecutively. The two groups of patients were similar for all the demographic, clinical, and pathological characteristics, and all the intraoperative factors considered except the number of resected lymph nodes (mean number per case=34.2 \u00b1 15.5\u00a0in the EPD group versus 12.8 \u00b1 3.6\u00a0in the SPD group, <jats:italic>p<\/jats:italic>&lt;0.001) and the operative time (median time per case=375\u00a0minutes in the EPD group versus 270\u00a0minutes in the SPD group, <jats:italic>p<\/jats:italic>=0.009). Patients in the two groups experienced a similar postoperative course. The estimated survival probability at 1 and 3 years after operation was 0.76 (95% confidence interval [CI]: 0.49 to 0.90) and 0.24 (95% CI: 0.07 to 0.45) in the EPD group; 0.31 (95% CI: 0.09 to 0.55) and 0.08 (95% CI: 0.00 to 0.29) in the SPD group (<jats:italic>p<\/jats:italic>=0.014). According to a Cox model, the treatment was associated with R0 patients\u2019 long\u2010term survival (SPD versus EPD: hazard ratio (HR)=4.82, 95% CI: 1.66 to 14.00, <jats:italic>p<\/jats:italic>=0.004). Grading of tumor differentiation was confirmed to be a relevant prognostic factor (poor versus moderate: HR=4.33, 95% CI: 1.49 to 12.61, <jats:italic>p<\/jats:italic>=0.007), whereas type of resection had no significant effect (pylorus\u2010preserving versus hemigastrectomy: HR=1.49, 95% CI: 0.56 to 3.95, <jats:italic>p<\/jats:italic>=0.42). The proportion of R0 patients with local recurrence was lower in the EPD group (20.0% versus 70.0%, <jats:italic>p<\/jats:italic>=0.034).<\/jats:p>","DOI":"10.1007\/s00268-002-5976-6","type":"journal-article","created":{"date-parts":[[2002,11,21]],"date-time":"2002-11-21T22:31:26Z","timestamp":1037917886000},"page":"1309-1314","source":"Crossref","is-referenced-by-count":33,"title":["Results of pancreaticoduodenectomy for pancreatic cancer: Extended versus standard procedure"],"prefix":"10.1002","volume":"26","author":[{"given":"Calogero","family":"Iacono","sequence":"first","affiliation":[{"name":"Department of Surgery Division of General Surgery C University of Verona University Hospital 37134 Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Accordini","sequence":"additional","affiliation":[{"name":"Unit of Epidemiology and Medical Statistics University of Verona 37134 Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Bortolasi","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of General Surgery C University of Verona University Hospital 37134 Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Facci","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of General Surgery C University of Verona University Hospital 37134 Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Zamboni","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Verona University Hospital 37134 Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ettore","family":"Montresor","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of General Surgery C University of Verona University Hospital 37134 Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Domenico","family":"Marinello","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of General Surgery C University of Verona University Hospital 37134 Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Serio","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of General Surgery C University of Verona University Hospital 37134 Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010198808000\u201000014"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097\u20100142(19960215)77:4<640::AID\u2010CNCR9>3.0.CO;2\u2010K"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010198404000\u201000008"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1989.01410010137027"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1091\u2010255X(97)80132\u20101"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010199810000\u201000007"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010199905000\u201000003"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02469594"},{"key":"e_1_2_1_10_1","volume-title":"General Rules for Surgery and Pathological Studies on Cancer of the Pancreas","author":"Japanese Pancreatic Society","year":"1986"},{"key":"e_1_2_1_11_1","first-page":"397","article-title":"Les pancreatectomies avec curage ganglionnaire","volume":"93","author":"Couinaud C","year":"1967","journal-title":"J. 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A propos d\u2019une s\u00e9rie de 59 cas","volume":"120","author":"Masson B","year":"1994","journal-title":"Chirurgie"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002\u20109610(05)80406\u20104"},{"key":"e_1_2_1_26_1","first-page":"855","article-title":"Ductal adenocarcinoma of the pancreas head: survival after regional versus extended lymphadenectomy","volume":"45","author":"Henne\u2010Bruns D","year":"1998","journal-title":"Hepato\u2010Gastroenterology"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s005340050086"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097\u20100142(19921015)70:8<2061::AID\u2010CNCR2820700808>3.0.CO;2\u2010V"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002\u20109610(05)80167\u20109"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002689910089"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-002-5976-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-002-5976-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-002-5976-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T15:57:52Z","timestamp":1704988672000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-002-5976-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,11]]},"references-count":29,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2002,11]]}},"alternative-id":["10.1007\/s00268-002-5976-6"],"URL":"https:\/\/doi.org\/10.1007\/s00268-002-5976-6","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,11]]}}}