{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T16:24:25Z","timestamp":1788625465938,"version":"build-2803163510"},"reference-count":0,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2002,6,24]],"date-time":"2002-06-24T00:00:00Z","timestamp":1024876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2002,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Anterior resection and abdomino\u2010perineal resection are the surgical techniques used most frequently in the treatment of rectal cancer. Local recurrence rates of 10% to 14% are described after these conventional procedures. Preoperative neoadjuvant radiotherapy reduces local failure. Because local excision techniques can be applied to treat early rectal cancer in selected patients, we evaluated the results of preoperative high\u2010dose radiotherapy and transanal endoscopic microsurgical excision (TEM) in patients with T2 rectal cancer. All patients underwent preoperative irradiation with 5,040 cGy, divided over 5 weeks. Fourty days after completion of radiotherapy, the patients underwent complete full\u2010thickness local excision of the rectal lesion including adjacent perirectal fat by TEM. The patients were followed for up to 8 years. Thirty\u2010five patients, with pT2 rectal cancer as determined by pathological examination of the surgical specimen were enrolled in the present study. The tumors were responsive to preoperative radiotherapy in 82.8% of cases. No intraoperative complications and no conversion to open surgery were observed. No major complications and no mortality occurred during the 60\u2010day postoperative period. Minor postoperative complications were observed in 5 patients (14.3%). The median follow\u2010up of the patients was 38\u00a0months (range 24 to 96\u00a0months). One local recurrence (2.85%) was noted. The probability of surviving at 96\u00a0months after completion of treatment was 83%. Local excision by TEM combined with preoperative high\u2010dose radiotherapy can achieve results similar to those observed after conventional surgery in patients with pT2 rectal cancer.\n<\/jats:p>","DOI":"10.1007\/s00268-002-6359-8","type":"journal-article","created":{"date-parts":[[2003,11,19]],"date-time":"2003-11-19T20:53:30Z","timestamp":1069275210000},"page":"1170-1174","source":"Crossref","is-referenced-by-count":91,"title":["Long\u2010term Results of Patients with pT2 Rectal Cancer Treated with Radiotherapy and Transanal Endoscopic Microsurgical Excision"],"prefix":"10.1002","volume":"26","author":[{"given":"Emanuele","family":"Lezoche","sequence":"first","affiliation":[{"name":"II Clinica Chirurgica Department of Surgery \"P. Stefanini \" University of Roma \"La Sapienza,\" Viale del Policlinico 155 00161 Roma Italy<!--<country1>ITALY<\/country1>-->"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Guerrieri","sequence":"additional","affiliation":[{"name":"Clinica di Chirurgia Generale Umberto I Hospital University of Ancona Piazza Cappelli 1 60121 Ancona Italy<!--<country1>ITALY<\/country1>-->"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro M.","family":"Paganini","sequence":"additional","affiliation":[{"name":"Clinica di Chirurgia Generale Umberto I Hospital University of Ancona Piazza Cappelli 1 60121 Ancona Italy<!--<country1>ITALY<\/country1>-->"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Feliciotti","sequence":"additional","affiliation":[{"name":"Clinica di Chirurgia Generale Umberto I Hospital University of Ancona Piazza Cappelli 1 60121 Ancona Italy<!--<country1>ITALY<\/country1>-->"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,6,24]]},"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-002-6359-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-002-6359-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-002-6359-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T20:41:58Z","timestamp":1703709718000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-002-6359-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,6,24]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2002,9]]}},"alternative-id":["10.1007\/s00268-002-6359-8"],"URL":"https:\/\/doi.org\/10.1007\/s00268-002-6359-8","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,6,24]]}}}