{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:54:09Z","timestamp":1790690049229,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2002,11,1]],"date-time":"2002-11-01T00:00:00Z","timestamp":1036108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2002,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Anastomotic insufficiency is considered to be one of the most serious complications associated with esophageal reconstruction. The purposes of this study were to identify (1) the relationship between anastomotic insufficiency and tissue blood flow (TBF) in the gastric tube in the perioperative period, and (2) the effects of intravenous prostaglandin E<jats:sub>1<\/jats:sub> (PGE<jats:sub>1<\/jats:sub>) on TBF in the gastric tube. The study group consisted of 44 patients who were to undergo esophagectomy for esophageal cancer. Intraoperative and postoperative TBF on the serosal side of the gastric tube were measured by laser\u2010Doppler tissue blood flowmetry. The TBF of the Leakage(+) group (<jats:italic>n<\/jats:italic>=5) was poorer than that of the Leakage(\u2212) group (<jats:italic>n<\/jats:italic>=39) during the intraoperative and postoperative periods. There was a significant difference in TBF between the two groups at postoperative day (POD) 3. There was a tendency in the PGE<jats:sub>1<\/jats:sub>(+) group (<jats:italic>n<\/jats:italic>=18) to exhibit richer blood flow through the anastomosis than the PGE<jats:sub>1<\/jats:sub>(\u2212) group (<jats:italic>n<\/jats:italic>=26), intraoperatively, but the difference was not significant. Two of five Leakage(+) cases were also in the PGE<jats:sub>1<\/jats:sub>1(+) group. There was no relationship between intraoperative medication with PGE<jats:sub>1<\/jats:sub> and incidence of leakage. The TBF of three\u2010field lymph node dissection and reconstruction of the retrosternal route group (<jats:italic>n<\/jats:italic>=21) was poorer than that of the two\u2010field lymph\u2010node dissection and reconstruction of the posterior mediastinal route group (<jats:italic>n<\/jats:italic>=23). The TBF in the gastric tube after esophagectomy may be a predictor of anastomotic insufficiency. However, PGE<jats:sub>1<\/jats:sub> treatment in the intraoperative period alone is not effective in preventing anastomotic insufficiency.<\/jats:p>","DOI":"10.1007\/s00268-002-6366-9","type":"journal-article","created":{"date-parts":[[2002,11,21]],"date-time":"2002-11-21T22:31:26Z","timestamp":1037917886000},"page":"1319-1323","source":"Crossref","is-referenced-by-count":77,"title":["Predictive value of blood flow in the gastric tube in anastomotic insufficiency after thoracic esophagectomy"],"prefix":"10.1002","volume":"26","author":[{"given":"Tatsuya","family":"Miyazaki","sequence":"first","affiliation":[{"name":"Department of Surgery I Gunma University Faculty of Medicine 3\u201039\u201022, Showa\u2010machi, Maebashi 371\u20108511 Gunma Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Kuwano","sequence":"additional","affiliation":[{"name":"Department of Surgery I Gunma University Faculty of Medicine 3\u201039\u201022, Showa\u2010machi, Maebashi 371\u20108511 Gunma Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Surgery I Gunma University Faculty of Medicine 3\u201039\u201022, Showa\u2010machi, Maebashi 371\u20108511 Gunma Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minako","family":"Yoshikawa","sequence":"additional","affiliation":[{"name":"Department of Surgery I Gunma University Faculty of Medicine 3\u201039\u201022, Showa\u2010machi, Maebashi 371\u20108511 Gunma Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Ojima","sequence":"additional","affiliation":[{"name":"Department of Surgery I Gunma University Faculty of Medicine 3\u201039\u201022, Showa\u2010machi, Maebashi 371\u20108511 Gunma Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhiko","family":"Tsukada","sequence":"additional","affiliation":[{"name":"Department of Surgery I Gunma University Faculty of Medicine 3\u201039\u201022, Showa\u2010machi, Maebashi 371\u20108511 Gunma Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)33811-5"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010199409000\u201000012"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00294412"},{"key":"e_1_2_1_5_1","first-page":"421","volume-title":"Disease of the Esophagus, Pathophysiology, Diagnosis, Conservative and Surgical Treatment","author":"Yoshida M","year":"1998"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00316816"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010199511000\u201000008"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002\u20109610(80)90193\u20102"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800691217"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800720113"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00316817"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930540109"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00316812"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/110241598750005679"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002\u20109610(92)90393\u20106"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002\u20109610(99)80238\u20104"},{"key":"e_1_2_1_17_1","first-page":"599","article-title":"Impaired healing of cervical oesophagogastrostomies can be predicted by estimation of gastric serosal blood perfusion by laser\u2010Doppler flowmetry","volume":"160","author":"Pierie JP","year":"1994","journal-title":"Eur. J. Surg."},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246\u2010199909000\u201000020"},{"key":"e_1_2_1_19_1","first-page":"660","volume-title":"The Pharmacological Basis of Therapeutics","author":"Moneada S","year":"1985"},{"key":"e_1_2_1_20_1","first-page":"631","article-title":"A canine model for measuring tissue blood flow of small intestine by laser flowmetry","volume":"18","author":"Oka S","year":"1988","journal-title":"Kitasato Med."},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022\u20104804(71)90113\u20102"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02468717"},{"key":"e_1_2_1_23_1","first-page":"H34","article-title":"Motility and blood flow distribution within the wall of the gastrointestinal tract","volume":"235","author":"Chou CC","year":"1978","journal-title":"Am. J. Physiol."},{"key":"e_1_2_1_24_1","first-page":"H25","article-title":"Determination of blood flow and shunting of 9 and 15\u2010micrometer spheres in regional beds","volume":"237","author":"Fan FC","year":"1979","journal-title":"Am. J. Physiol."},{"key":"e_1_2_1_25_1","first-page":"G668","article-title":"Continuous measurement of intestinal mucosal blood flow by laser\u2010Doppler velocimetry","volume":"242","author":"Shepherd AP","year":"1982","journal-title":"Am. J. Phvsiol."},{"key":"e_1_2_1_26_1","first-page":"G617","article-title":"Differences in reactive hyperemia between the intestinal mucosa and musclaris","volume":"247","author":"Shepherd AP","year":"1984","journal-title":"Am. J. Physiol."},{"key":"e_1_2_1_27_1","first-page":"G221","article-title":"Laser\u2010Doppler, H2 clearance, and microsphere estimates of mucosal blood flow","volume":"249","author":"Kvietys PR","year":"1985","journal-title":"Am. J. Physiol."},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003\u20104975(99)00065\u2010X"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01659093"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-002-6366-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-002-6366-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-002-6366-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T15:59:12Z","timestamp":1704988752000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-002-6366-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,11]]},"references-count":28,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2002,11]]}},"alternative-id":["10.1007\/s00268-002-6366-9"],"URL":"https:\/\/doi.org\/10.1007\/s00268-002-6366-9","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,11]]}}}