{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T20:23:07Z","timestamp":1789676587885,"version":"4.0.1"},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,2,28]],"date-time":"2014-02-28T00:00:00Z","timestamp":1393545600000},"content-version":"vor","delay-in-days":4107,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2002,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Laparoscopic techniques have become a standard approach for diagnostic and therapeutic procedures in many surgical disciplines. Recent progress in endoscopic surgery is based on the integration of computer\u2010enhanced telemanipulation systems. Because robot\u2010assisted radical prostatectomies take up to 10 hours, the present study was performed to evaluate the effects of prolonged intraperitoneal CO<jats:sub>2<\/jats:sub> insufflation on hemodynamics and gas exchange in 15 patients with prostate cancer. When CO<jats:sub>2<\/jats:sub> insufflation was initiated, peak inspiratory pressure increased and reached significant values after a 1.5\u2010hour period of intraperitoneal CO<jats:sub>2<\/jats:sub> insufflation. With the release of CO<jats:sub>2<\/jats:sub>, peak inspiratory pressure decreased close to baseline values. A significant increase in heart rate was observed after a 4\u2010hour period of increased intraabdominal pressure. Mean arterial blood pressure and central venous pressure remained stable during CO<jats:sub>2<\/jats:sub> insufflation. Minute ventilation was adjusted according to repeated blood gas analyses to maintain pH, base excess (BE), bicarbonate (HCO<jats:sub>3<\/jats:sub><jats:sup>\u2212<\/jats:sup>), and PaCO<jats:sub>2<\/jats:sub> within physiologic ranges. The present data show, that prolonged CO<jats:sub>2<\/jats:sub> insufflation during totally endoscopic robot\u2010assisted radical prostatectomy results in only minor changes in hemodynamics and acid\u2010base status. Because of the limited experience with long\u2010term pneumoperitoneum, we consider invasive haemodynamic monitoring and repeat blood gas analysis essential for such operations.<\/jats:p>","DOI":"10.1007\/s00268-002-6404-7","type":"journal-article","created":{"date-parts":[[2002,12,5]],"date-time":"2002-12-05T15:48:22Z","timestamp":1039103302000},"page":"1423-1427","source":"Crossref","is-referenced-by-count":47,"title":["Effects of prolonged pneumoperitoneum on hemodynamics and acid\u2010base balance during totally endoscopic robot\u2010assisted radical prostatectomies"],"prefix":"10.1002","volume":"26","author":[{"given":"Dirk","family":"Meininger","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Intensive Care Medicine, and Pain Control J.W. 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