{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T23:36:51Z","timestamp":1789429011838,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,2,28]],"date-time":"2014-02-28T00:00:00Z","timestamp":1393545600000},"content-version":"vor","delay-in-days":4107,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2002,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Total thyroidectomy is not frequently performed in cases of benign disease because of the associated risk of postoperative hypoparathyroidism and recurrent laryngeal nerve (RLN) damage. We chose a series of patients who had undergone total thyroidectomy (TT) for benign thyroid tumors to evaluate the safety of this approach and its role in the treatment of nonmalignant lesions of the thyroid. We considered only patients with a minimum follow\u2010up of 24\u00a0months. Records of 526 patients who underwent TT were carefully reviewed, assessing for perioperative complications and late sequelae. The mean age was 44 \u00b1 15.7 years; 109 patients (20.7%) were male and 417 (79.3%) were female. Altogether, 65 patients (12.3%) were operated on for toxic goiter, 429 (81.6%) for bilateral nodular goiter, and 32 (6.1%) for thyroiditis. Postoperative hemorrhage requiring reoperation occurred in 8 cases (1.5%). The incidences of permanent RLN palsy (considered as a percentage of the nerves at risk) and permanent hypocalcemia were 0.4% and 3.4%, respectively. A trend toward a decrease in the complication rate was observed during the last 5 years. There were no disease recurrences during a mean follow\u2010up of 44\u00a0months. The results of our series show that TT can be performed safely in patients, with a low incidence of lifetime disabilities. TT has the advantage of reducing\/avoiding the risk of disease recurrence and reoperation and should therefore be considered a valuable option for treating benign thyroid diseases.<\/jats:p>","DOI":"10.1007\/s00268-002-6426-1","type":"journal-article","created":{"date-parts":[[2002,12,5]],"date-time":"2002-12-05T15:48:22Z","timestamp":1039103302000},"page":"1468-1471","source":"Crossref","is-referenced-by-count":119,"title":["Total thyroidectomy for management of benign thyroid disease: Review of 526 cases"],"prefix":"10.1002","volume":"26","author":[{"given":"Rocco","family":"Bellantone","sequence":"first","affiliation":[{"name":"Divisione di Endocrinochirurgia Dipartimento di Scienze Chirurgiche Universit\u00e0 Cattolica del Sacro Cuore L. go A. Gemelli 8 00168 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celestino Pio","family":"Lombardi","sequence":"additional","affiliation":[{"name":"Divisione di Endocrinochirurgia Dipartimento di Scienze Chirurgiche Universit\u00e0 Cattolica del Sacro Cuore L. go A. Gemelli 8 00168 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Bossola","sequence":"additional","affiliation":[{"name":"Divisione di Endocrinochirurgia Dipartimento di Scienze Chirurgiche Universit\u00e0 Cattolica del Sacro Cuore L. go A. Gemelli 8 00168 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Boscherini","sequence":"additional","affiliation":[{"name":"Divisione di Endocrinochirurgia Dipartimento di Scienze Chirurgiche Universit\u00e0 Cattolica del Sacro Cuore L. go A. Gemelli 8 00168 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmela","family":"De Crea","sequence":"additional","affiliation":[{"name":"Divisione di Endocrinochirurgia Dipartimento di Scienze Chirurgiche Universit\u00e0 Cattolica del Sacro Cuore L. go A. Gemelli 8 00168 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierfrancesco","family":"Alesina","sequence":"additional","affiliation":[{"name":"Divisione di Endocrinochirurgia Dipartimento di Scienze Chirurgiche Universit\u00e0 Cattolica del Sacro Cuore L. go A. Gemelli 8 00168 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Traini","sequence":"additional","affiliation":[{"name":"Divisione di Endocrinochirurgia Dipartimento di Scienze Chirurgiche Universit\u00e0 Cattolica del Sacro Cuore L. go A. 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