{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:10:44Z","timestamp":1785773444881,"version":"3.56.0"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,2,28]],"date-time":"2014-02-28T00:00:00Z","timestamp":1393545600000},"content-version":"vor","delay-in-days":4107,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2002,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Primary hyperparathyroidism (pHPT) is associated with an increased fracture risk, and decreased bone density thus has been considered an indication for surgery. However, many pHPT patients have a multifactorial risk profile for osteoporosis and bone fractures. The aim of the present study was to evaluate variables associated with fracture risk within the group of pHPT patients. A series of 203 consecutive patients operated for pHPT were investigated with bone mineral content and biochemical and clinical risk factors for bone fracture. Seventeen patients (8%) had a history of at least one bone fracture up to 5 years before pHPT surgery. Twenty\u2010six patients (13%) had a history of at least one fracture during the 10\u2010year period prior to surgery. In the univariate analyses corticosteroid treatment, serum levels of alkaline phosphatase, 25\u2010hydroxyvitamin D<jats:sub>3<\/jats:sub>, type I collagen telopeptide, and bone mineral content were found to be associated with a history of bone fractures up to 10 years before surgery. Additionally, age and menopausal status were of importance for fractures during the 10\u2010year\u2010period, whereas a history of cardiovascular disease was important for fractures during the 5\u2010year\u2010period prior to surgery. Multivariate analyses showed that serum level of PTH was independently associated with bone fractures during the 5\u2010year period prior to pHPT surgery and further that serum level of 25\u2010hydroxyvitamin D<jats:sub>3<\/jats:sub> was associated with fractures up to 10 years before surgery. In conclusion, serum levels of 25\u2010hydroxyvitamin D<jats:sub>3<\/jats:sub> and PTH were independently associated with a history of bone fractures in pHPT. These variables should be considered when evaluating patients for parathyroid surgery.<\/jats:p>","DOI":"10.1007\/s00268-002-6433-2","type":"journal-article","created":{"date-parts":[[2002,12,5]],"date-time":"2002-12-05T15:48:22Z","timestamp":1039103302000},"page":"1463-1467","source":"Crossref","is-referenced-by-count":47,"title":["Multifactorial risk profile for bone fractures in primary hyperparathyroidism"],"prefix":"10.1002","volume":"26","author":[{"given":"Erik","family":"Nordenstr\u00f6m","sequence":"first","affiliation":[{"name":"Department of Surgery Lund University Hospital S\u2010221 85 Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Westerdahl","sequence":"additional","affiliation":[{"name":"Department of Surgery Lund University Hospital S\u2010221 85 Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birger","family":"Linderg\u00e5rd","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Lund University Hospital S\u2010221 85 Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"Lindblom","sequence":"additional","affiliation":[{"name":"Department of Surgery Lund University Hospital S\u2010221 85 Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Bergenfelz","sequence":"additional","affiliation":[{"name":"Department of Surgery Lund University Hospital S\u2010221 85 Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,28]]},"reference":[{"issue":"2","key":"e_1_2_1_2_1","first-page":"S63","article-title":"Clinical spectrum of primary hyperparathyroidism: evolution with changes in medical practice and technology","volume":"6","author":"Heath H","year":"1991","journal-title":"J. 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