{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T00:02:56Z","timestamp":1705017776449},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2003,4,1]],"date-time":"2003-04-01T00:00:00Z","timestamp":1049155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2003,4]]},"abstract":"<jats:p>Abstract<\/jats:p><jats:p>We investigated the incidence of recurrence after resection of small hepatocellular carcinomas (HCC) in patients infected with hepatitis C virus (HCV) to determine the appropriate surgical management of these patients. Sixty\u2010one patients with anti\u2010HCV antibody who underwent curative liver resection for small HCC (\u2266 2.0\u00a0cm in greatest diameter) were categorized into two groups. Group 1 consisted of 27 patients with serum concentrations of type IV collagen 7S domain (7S collagen), a marker for hepatic fibrosis, &lt; 8\u00a0ng\/ml. Group 2 consisted of 34 patients with serum concentrations of 7S collagen \u2267 8\u00a0ng\/ml. Serum concentration of 7S collagen correlated with the severity of active hepatitis and the degree of fibrosis in the noncancerous hepatic tissue, both of which are related to risk potential of hepatocarcinogenesis. Serum concentration of total bilirubin, aspartate aminotransferase activity, indocyanine green retention rate at 15\u00a0minutes, the proportion of patients who were Child\u2010Pugh class B, and the proportion of patients with severe active hepatitis or cirrhosis (determined by histologic examination) were significantly higher in group 2 than in group 1. Platelet count was significantly lower in group 2. Tumor\u2010free survival rates were not different between the groups. In group 1, nonanatomic resection was a risk factor for recurrence by univariate and multivariate analyses (odds ratio = 3.45, <jats:italic>p<\/jats:italic> = 0.040). In group 2, nonanatomic resection was not a risk factor for recurrence. In patients with small HCV\u2010related HCC, anatomic resection is recommended when the serum concentration of 7S collagen is low (&lt; 8\u00a0ng\/ml) because the potential of hepatocarcinogenesis may be low even after the operation.<\/jats:p>","DOI":"10.1007\/s00268-002-6475-5","type":"journal-article","created":{"date-parts":[[2003,3,25]],"date-time":"2003-03-25T19:02:58Z","timestamp":1048618978000},"page":"437-442","source":"Crossref","is-referenced-by-count":6,"title":["Appropriate Surgical Management of Small Hepatocellular Carcinomas in Patients Infected with Hepatitis C Virus"],"prefix":"10.1002","volume":"27","author":[{"given":"Shoji","family":"Kubo","sequence":"first","affiliation":[{"name":"Department of Gastroenterological and Hepato\u2010Biliary\u2010Pancreatic Surgery Osaka City University Graduate School of Medicine 1\u20104\u20103 Asahimachi, Abeno\u2010ku 545\u20108585 Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Taukamoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and Hepato\u2010Biliary\u2010Pancreatic Surgery Osaka City University Graduate School of Medicine 1\u20104\u20103 Asahimachi, Abeno\u2010ku 545\u20108585 Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Hirohashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and Hepato\u2010Biliary\u2010Pancreatic Surgery Osaka City University Graduate School of Medicine 1\u20104\u20103 Asahimachi, Abeno\u2010ku 545\u20108585 Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromu","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and Hepato\u2010Biliary\u2010Pancreatic Surgery Osaka City University Graduate School of Medicine 1\u20104\u20103 Asahimachi, Abeno\u2010ku 545\u20108585 Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taichi","family":"Shuto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and Hepato\u2010Biliary\u2010Pancreatic Surgery Osaka City University Graduate School of Medicine 1\u20104\u20103 Asahimachi, Abeno\u2010ku 545\u20108585 Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigekazu","family":"Takemura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and Hepato\u2010Biliary\u2010Pancreatic Surgery Osaka City University Graduate School of Medicine 1\u20104\u20103 Asahimachi, Abeno\u2010ku 545\u20108585 Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuichi","family":"Kawai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and Hepato\u2010Biliary\u2010Pancreatic Surgery Osaka City University Graduate School of Medicine 1\u20104\u20103 Asahimachi, Abeno\u2010ku 545\u20108585 Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Wakasa","sequence":"additional","affiliation":[{"name":"Department of Pathology Osaka City University Hospital 1\u20105\u20103 Asahimachi, Abeno\u2010ku 545\u20108586 Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and Hepato\u2010Biliary\u2010Pancreatic Surgery Osaka City University Graduate School of Medicine 1\u20104\u20103 Asahimachi, Abeno\u2010ku 545\u20108585 Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,4]]},"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-002-6475-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-002-6475-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-002-6475-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T16:17:53Z","timestamp":1704989873000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-002-6475-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,4]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2003,4]]}},"alternative-id":["10.1007\/s00268-002-6475-5"],"URL":"https:\/\/doi.org\/10.1007\/s00268-002-6475-5","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,4]]}}}