{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T10:19:47Z","timestamp":1775211587853,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,2,28]],"date-time":"2014-02-28T00:00:00Z","timestamp":1393545600000},"content-version":"vor","delay-in-days":4107,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2002,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Endoscopic thermal therapy and formalin are being increasingly recommended for the treatment of chronic hemorrhagic radiation proctitis. It may be too early, however, to discard pharmacologic agents from the management process, especially in medical institutions where specialized equipment is unavailable. We prospectively assessed the effectiveness of medical therapy in 14 consecutive patients with chronic hemorrhagic radiation proctitis from July 1999 to June 2001. All 14 subjects were women (mean age 56 years), 13 of whom had had radio\u2010therapy for Cancer of the cervix. The median time to onset of Symptoms following irradiation was 16\u00a0months. Six patients had a hemoglobin level of&lt;8\u00a0g\/dl, and blood transfusion was required in 11 patients. In five patients (36%) initially treated with hydrocortisone enemas prior to referral, this treatment continued; and the remaining nine patients were commenced on sucralfate enemas. Two patients given rectal hydrocortisone continued to bleed and were treated with sucralfate enemas and topical formalin, respectively. Rectal sucralfate Suspension effectively procured symptomatic alleviation in all 11 patients. Rectal bleeding recurred in two patients who had been managed exclusively with hydrocortisone and sucralfate enemas, respectively, over a mean follow\u2010up of 6\u00a0months. Both patients were managed with topical formalin, which con\u2010trolled their Symptoms. Even though the number of subjects in this study is small, sucralfate enema can be recommended as an effective first\u2010line agent for managing patients with chronic hemorrhagic radiation proctitis. The use of more specialized therapy can therefore be reserved for cases where primary treatment failure occurs with sucralfate therapy.<\/jats:p>","DOI":"10.1007\/s00268-002-6529-8","type":"journal-article","created":{"date-parts":[[2002,12,5]],"date-time":"2002-12-05T15:48:22Z","timestamp":1039103302000},"page":"1499-1502","source":"Crossref","is-referenced-by-count":40,"title":["Pharmacotherapy for chronic hemorrhagic radiation proctitis"],"prefix":"10.1002","volume":"26","author":[{"given":"Yunus A.","family":"Gul","sequence":"first","affiliation":[{"name":"Department of Surgery University Putra Malaysia 43400 Serdang Selangor Malaysia"},{"name":"Department of General Surgery University Putra Malaysia 8th Floor, Grand Seasons Avenue, 72\u00a0Jln Pahang 53000 Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subhita","family":"Prasannan","sequence":"additional","affiliation":[{"name":"Department of Surgery University Putra Malaysia 43400 Serdang Selangor Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faisal M.","family":"Jabar","sequence":"additional","affiliation":[{"name":"Department of Surgery University Putra Malaysia 43400 Serdang Selangor Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdul R. H.","family":"Shaker","sequence":"additional","affiliation":[{"name":"Department of Surgery University Putra Malaysia 43400 Serdang Selangor Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Moissinac","sequence":"additional","affiliation":[{"name":"Department of Surgery University Putra Malaysia 43400 Serdang Selangor Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,28]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(16)46138-4"},{"key":"e_1_2_1_3_1","first-page":"40","article-title":"The natural history of radiation\u2010induced proctosigmoiditis: an analysis of 88 patients","volume":"52","author":"Glinsky NH","year":"1983","journal-title":"Q.J. 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