{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T22:57:28Z","timestamp":1789772248725,"version":"4.0.1"},"reference-count":0,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2002,8,1]],"date-time":"2002-08-01T00:00:00Z","timestamp":1028160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2002,8]]},"abstract":"<jats:p>This study assessed the impact of parathyroidectomy on the preoperative symptoms of patients with primary hyperparathyroidism (1\u00b0 HPT) using a surgical outcome tool designed specifically for HPT. The multicenter nature of this study allowed us to validate further this disease\u2010specific outcome tool. 1\u00b0 HPT patients from Canada, the United States, and Australia filled out the questionnaire preoperatively and postoperatively on day 7 and at 3 and\n12\u00a0months. The symptoms recorded by the patients were expressed as parathyroidectomy assessment of symptoms (PAS) scores: the higher the score, the more symptomatic is the patient. Quality of Life (QOL) and self\u2010rated health uni\u2010scales were included. Altogether, 203 patients with 1\u00b0 HPT were enrolled; 27 from center A, 54 from center B, and 122 from center C; 58\nnontoxic thyroid patients were enrolled for comparison. The comparison group had no significant change in their PAS scores throughout the study (scores 184, 215, 156, 186). All three centers demonstrated a significant reduction in symptoms following surgery. The median preoperative PAS score from center B patients was 282. Following surgery, PAS scores decreased significantly: 136, 58, 0\n(p &lt;0.05). Center C patients had a median preoperative PAS score of 344, decreasing postoperatively to 228 (p\n&lt;0.05) and continuing to decrease to 190, then 180. Center A also demonstrated a significant reduction in symptoms at 3\u00a0months, from 510\npreoperatively to 209 (p &lt;0.001). Both QOL and self\u2010rated health improved in the HPT patients, whereas no change was found in the comparison group following surgery. PAS scores are a reliable, disease\u2010specific measure of symptoms seen with HPT.\nParathyroidectomy significantly reduces these preoperative symptoms,\nand this change translated into an improved health\u2010related QOL for the patients.<\/jats:p>","DOI":"10.1007\/s00268-002-6623-y","type":"journal-article","created":{"date-parts":[[2002,10,14]],"date-time":"2002-10-14T12:45:16Z","timestamp":1034599516000},"page":"942-949","source":"Crossref","is-referenced-by-count":149,"title":["Patient\u2010based Surgical Outcome Tool Demonstrating Alleviation of Symptoms following Parathyroidectomy in Patients with Primary Hyperparathyroidism"],"prefix":"10.1002","volume":"26","author":[{"given":"Janice L.","family":"Pasieka","sequence":"first","affiliation":[{"name":"Department of Surgery Division of General Surgery University of Calgary Foothills Medical Center 1403 29th Street NW Calgary Alberta Canada T2N2T9<!--<country1>CANADA<\/country1>-->"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise L.","family":"Parsons","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of General Surgery University of Calgary Foothills Medical Center 1403 29th Street NW Calgary Alberta Canada T2N2T9<!--<country1>CANADA<\/country1>-->"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Demeure","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of General Surgery Medical College of Wisconsin 9200 West Wisconsin Avenue Milwaukee Wisconsin 53226 USA<!--<country1>USA<\/country1>-->"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of General Surgery Medical College of Wisconsin 9200 West Wisconsin Avenue Milwaukee Wisconsin 53226 USA<!--<country1>USA<\/country1>-->"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Malycha","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of General Surgery University of Adelaide 333 South Terrace Adelaide South Australia 5000 Australia<!--<country1>AUSTRALIA<\/country1>-->"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of General Surgery University of Calgary Foothills Medical Center 1403 29th Street NW Calgary Alberta Canada T2N2T9<!--<country1>CANADA<\/country1>-->"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"Krzywda","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of General Surgery Medical College of Wisconsin 9200 West Wisconsin Avenue Milwaukee Wisconsin 53226 USA<!--<country1>USA<\/country1>-->"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,8]]},"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-002-6623-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-002-6623-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-002-6623-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T15:18:04Z","timestamp":1703690284000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-002-6623-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,8]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2002,8]]}},"alternative-id":["10.1007\/s00268-002-6623-y"],"URL":"https:\/\/doi.org\/10.1007\/s00268-002-6623-y","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,8]]}}}