{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T21:57:15Z","timestamp":1783634235259,"version":"3.55.0"},"reference-count":0,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2002,8,1]],"date-time":"2002-08-01T00:00:00Z","timestamp":1028160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2002,8]]},"abstract":"<jats:p>\nTumors derived from hormone\u2010producing cells are generally highly differentiated, and vast experience indicates benefit with combinations of surgical and medical treatment for metastatic disease. Tumor debulking surgery is an accepted approach for reducing hormonal symptoms and to establish better conditions for medical treatment. Radiofrequency treatment (RF), a novel method for destroying liver tumors, was used to treat 43 liver metastases in 21\npatients with endocrine tumors (12 with midgut carcinoid disease; 4\nwith nonfunctional endocrine pancreatic tumors; 1 with a VIPoma; 1 with a glucagonoma; 1 with a gastrinoma; 2 with adrenal carcinomas). Among these patients we treated with intention to cure in 14 by RF alone or RF plus surgery. Ablation was performed either percutaneously or intraoperatively using a cooled\u2010tip needle, applying 50 to 90 watts over 10 to 12\u00a0minutes under ultrasound guidance. Contrast\u2010enhanced computed tomography, liver function tests, and tumor markers were followed before and after RF. There were two complications: One patient suffered from conservatively treated bile leakage, and another had pleural effusion and fever for 7\u00a0days post\u2010RF. Two lesions developed signs of incomplete necrosis after 6\u00a0months, yielding a local recurrence rate of (4.6%). Of the 15 patients treated with curative intent, we attained cure (i.e., no residual macroscopic tumor) in 4\npatients. We conclude that RF using cooled\u2010tip needles is safe and efficient; it may be performed percutaneously and intraoperatively; and it may expand the indications for liver resection.\n<\/jats:p>","DOI":"10.1007\/s00268-002-6663-3","type":"journal-article","created":{"date-parts":[[2002,10,14]],"date-time":"2002-10-14T16:45:16Z","timestamp":1034613916000},"page":"1052-1056","source":"Crossref","is-referenced-by-count":122,"title":["Radiofrequency Tissue Ablation Using Cooled Tip for Liver Metastases of Endocrine Tumors"],"prefix":"10.1002","volume":"26","author":[{"given":"Per","family":"Hellman","sequence":"first","affiliation":[{"name":"Department of Surgery University Hospital SE\u2010751 85 Uppsala Sweden<!--<country1>SWEDEN<\/country1>-->"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Ladjevardi","sequence":"additional","affiliation":[{"name":"Department of Surgery University Hospital SE\u2010751 85 Uppsala Sweden<!--<country1>SWEDEN<\/country1>-->"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britt","family":"Skogseid","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences University Hospital SE\u2010751 85 Uppsala Sweden<!--<country1>SWEDEN<\/country1>-->"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6ran","family":"\u00c5kerstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Surgery University Hospital SE\u2010751 85 Uppsala Sweden<!--<country1>SWEDEN<\/country1>-->"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Elvin","sequence":"additional","affiliation":[{"name":"Department of Radiology Karolinska Institute 171 76 Stockholm Sweden<!--<country1>SWEDEN<\/country1>-->"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,8]]},"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-002-6663-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-002-6663-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-002-6663-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T20:18:15Z","timestamp":1703708295000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-002-6663-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,8]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2002,8]]}},"alternative-id":["10.1007\/s00268-002-6663-3"],"URL":"https:\/\/doi.org\/10.1007\/s00268-002-6663-3","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,8]]}}}