{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:15:15Z","timestamp":1791342915642,"version":"4.3.1"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2003,5,13]],"date-time":"2003-05-13T00:00:00Z","timestamp":1052784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2003,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A prospective, randomized, controlled trial was performed to determine the efficacy of somatostatin in the prevention of pancreatic stump\u2010related complications with elimination of surgeon\u2010related factors in high\u2010risk patients undergoing panceaticoduodenectomy. From August 1997 to December 2000, 54 patients, 28\u00a0men and 26 women, with age ranged from 32 to 89 years, were randomly assigned to somatostatin group (<jats:italic>n<\/jats:italic> = 27) or placebo group (<jats:italic>n<\/jats:italic> = 27). Ninety\u2010four percent of the patients had pancreatic and periampullary lesions; 6% had secondary lesion involving the duodenum such as local recurrent colon carcinoma and renal cell carcinoma. These patients received either standard pancreaticoduodenectomy or pylorus\u2010preserving pancreaticoduodenectomy. An experienced surgeon performed all operations in same fashion to minimize the surgical factor. A transanastomotic tube was inserted into the pancreatic duct for diversion of pancreatic juice in the pancreaticojejunostomy for a 3\u2010weeks period postoperatively. Intravenous infusion of somatostatin was given at a dose of 250\u03bcg\/hr in the somastotatin group and normal saline was given to the control group for 7\u00a0days postoperatively. There was one perioperative death in each group, resulting in a 3.7% mortality rate. In the somastotatin group, as compared to the placebo group, the incidence of overall morbidity and pancreatic stump related complications were significantly lower with a mean decrease of 50% pancreatic juice output and a slightly shorter duration of hospital stays. In conclusion, after excluding surgeon related factor, prophylactic use of somatostatin reduces the incidence and severity of pancreatic stump related complications in high\u2010risk patients having pancreaticoduodenectomy via decreased secretion of pancreatic exocrine.<\/jats:p>","DOI":"10.1007\/s00268-003-6693-5","type":"journal-article","created":{"date-parts":[[2004,1,28]],"date-time":"2004-01-28T21:29:48Z","timestamp":1075325388000},"page":"709-714","source":"Crossref","is-referenced-by-count":60,"title":["Role of Somatostatin in the Prevention of Pancreatic Stump\u2010related Morbidity following Elective Pancreaticoduodenectomy in High\u2010risk Patients and Elimination of Surgeon\u2010related Factors: Prospective, Randomized, Controlled Trial"],"prefix":"10.1002","volume":"27","author":[{"given":"Yan\u2010Shen","family":"Shan","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of General Surgery National Cheng Kung University 138, Sheng\u2010Li Road Tainan Taiwan"},{"name":"Institution of Clinical Medicine National Cheng Kung University 138, Sheng\u2010Li Rd Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar D.","family":"Sy","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of General Surgery National Cheng Kung University 138, Sheng\u2010Li Road Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pin\u2010Wen","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of General Surgery National Cheng Kung University 138, Sheng\u2010Li Road Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,5,13]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-194111440-00008"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198709000-00014"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1989.01410070028006"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010199709000\u201000004"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(91)91134-5"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199008000-00003"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198801000-00009"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800740803"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(16)45596-9"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(82)90064-2"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01671167"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.35.3_Suppl.S20"},{"key":"e_1_2_9_14_2","first-page":"14","volume-title":"Emerging Differences in the Therapeutic Efficacy of Somatostatin and Octreotide in Gastroenterology and Surgery","author":"Jenkins SA","year":"1996"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(88)80255-1"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000129423"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1155\/1997\/10729"},{"key":"e_1_2_9_18_2","first-page":"22","article-title":"Total pancreatic duct drainage for leakproof pancreaticojejunostomy","volume":"115","author":"Hamanaka Y","year":"1994","journal-title":"Surgery"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(78)90066-5"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1159\/000201179"},{"key":"e_1_2_9_21_2","first-page":"427","article-title":"Verhutung von postoperativen pankreatitischen koomplikationen nach duodenopankreatetomie durch somatostatin","volume":"50","author":"Klempa J","year":"1979","journal-title":"Chirurgia (Bucur)."},{"key":"e_1_2_9_22_2","first-page":"198","article-title":"Effects of somatostatin infusion on the pancreatic remnant secretions after pancreatoduodenectomy","volume":"45","author":"Gouillat C","year":"1998","journal-title":"Hepatogastroenterology."},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1159\/000051490"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(92)90264-R"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(05)80225-9"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800810237"},{"key":"e_1_2_9_27_2","first-page":"671","article-title":"Place de l\u2019octr\u00e9otide dans la pr\u00e9vention des complications chirurgicales apr\u00e8s pancr\u00e9atectome. \u00e9tude contr\u00f4l\u00e9e multicentrique","volume":"52","author":"Habib E","year":"1998","journal-title":"Ann. 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