{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T19:44:04Z","timestamp":1773085444101,"version":"3.50.1"},"reference-count":60,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,11,26]],"date-time":"2003-11-26T00:00:00Z","timestamp":1069804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There is a considerable discrepancy in the literature concerning the sensitivity of parathyroid scintigraphy (PS) with <jats:sup>99m<\/jats:sup>Tc\u2010MIBI. We therefore analyzed our own data and compared them to the literature in a metaanalysis. All patients who received <jats:sup>99m<\/jats:sup>Tc \u2010MIBI scintigraphy and subsequent surgery in our department for the detection of enlarged parathyroid glands in primary (pHPT) or secondary (sHPT) hyperparathyroidism between 1991 and 1999 were included in our retrospective analysis. The results of surgery served as the gold standard. For a true positive result, the scintigraphy had to predict the exact location of parathyroid adenoma (PA) or parathyroid hyperplasia (PH). We then compared these data to the results of a nonstatistical systematic metaanalysis of the literature. Patients (178) underwent PS between 1991 and 1999; 139 were operated on and included in this study. Of these, 109 had pHPT and 30 had sHPT. The sensitivity and specificity of the PS were found to be 45% \/ 94% for pHPT and 39% \/ 40% for sHPT. Fifty\u2010two studies concerning PS were included in the metaanalysis. Sensitivities reported varied from 39% to &gt; 90%. Consideration of the different possible techniques used for PS could not explain these discrepancies. Our data show that the sensitivity of PS in clinical routine may be lower than expected from the literature. Our data are consistent with other studies and with partially unpublished clinical observations from other university hospitals. We believe that a well\u2010designed and properly conducted prospective study is necessary to evaluate the reasons for the differences observed.<\/jats:p>","DOI":"10.1007\/s00268-003-6991-y","type":"journal-article","created":{"date-parts":[[2004,7,22]],"date-time":"2004-07-22T09:17:01Z","timestamp":1090487821000},"page":"100-107","source":"Crossref","is-referenced-by-count":89,"title":["Clinical Value of Parathyroid Scintigraphy with Technetium\u201099m Methoxyisobutylisonitrile: Discrepancies in Clinical Data and a Systematic Metaanalysis of the Literature"],"prefix":"10.1002","volume":"28","author":[{"given":"Martin","family":"Gotthardt","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine Philipps\u2010University of Marburg Baldingerstrasse 35043 Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bodo","family":"Lohmann","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Philipps\u2010University of Marburg Baldingerstrasse 35043 Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas M.","family":"Behr","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Philipps\u2010University of Marburg Baldingerstrasse 35043 Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Artur","family":"Bauhofer","sequence":"additional","affiliation":[{"name":"Department of Theoretical Surgery Philipps\u2010University of Marburg Baldingerstrasse 35043 Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiane","family":"Franzius","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University Hospital M\u00fcnster Albert\u2010Schweitzer\u2010Strasse 33 48129 M\u00fcnster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meike L.","family":"Schipper","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Philipps\u2010University of Marburg Baldingerstrasse 35043 Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Surgery Philipps\u2010University of Marburg Baldingerstrasse 35043 Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helmut","family":"H\u00f6ffken","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Philipps\u2010University of Marburg Baldingerstrasse 35043 Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helmut","family":"Sitter","sequence":"additional","affiliation":[{"name":"Department of Theoretical Surgery Philipps\u2010University of Marburg Baldingerstrasse 35043 Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Rothmund","sequence":"additional","affiliation":[{"name":"Department of Surgery Philipps\u2010University of Marburg Baldingerstrasse 35043 Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Joseph","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Philipps\u2010University of Marburg Baldingerstrasse 35043 Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Nies","sequence":"additional","affiliation":[{"name":"Department of Surgery Philipps\u2010University of Marburg Baldingerstrasse 35043 Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,11,26]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"1801","article-title":"Detection and localization of parathyroid adenomas in patients with hyperparathyroidism using a single radionuclide imaging procedure with technetium\u201099m\u2010sestamibi (double phase study)","volume":"33","author":"Taillifer R","year":"1992","journal-title":"J. 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