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It is well established that most, if not all, of these tumors develop in Barrett\u2019s esophagus via the metaplasia\u2010dysplasia\u2010carcinoma sequence and could theoretically be detected at an early stage, but despite this, the majority of these tumors are still detected late in their course. This highlights the fact that the goal of effective surveillance for patients at risk for developing an adenocarcinoma of the distal esophagus is still far off. In addition, adenocarcinomas of the esophagogastric junction and gastric cardia are also rising in incidence, but their carcinogenesis and their relation to Barrett\u2019s esophagus are still being defined, as are the meaning and significance of the relatively new entities \u201cshort\u2010segment Barrett\u2019s\u201d and \u201cultra\u2010short\u2010segment Barrett\u2019s\u201d. This review attempts to clarify the main histopathologic issues concerned with the definition of Barrett\u2019s esophagus, its distinction from intestinal metaplasia of the gastric cardia, as well as the criteria for the histologic diagnosis of dysplasia and carcinoma in Barrett\u2019s esophagus.<\/jats:p>","DOI":"10.1007\/s00268-003-7050-4","type":"journal-article","created":{"date-parts":[[2004,3,3]],"date-time":"2004-03-03T22:35:10Z","timestamp":1078353310000},"page":"148-154","source":"Crossref","is-referenced-by-count":39,"title":["Barrett\u2019s esophagus: Histopathologic definitions and diagnostic criteria"],"prefix":"10.1002","volume":"28","author":[{"given":"James","family":"Mueller","sequence":"first","affiliation":[{"name":"Department of Surgery Klinikum Rechts der Isar Technical University of Munich Ismaningerstrasse 22 D\u201081675 Munich Germany"},{"name":"Department of Pathology Bay\u2010state Medical Center 759 Chestnut Street 01199 Springfield Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Werner","sequence":"additional","affiliation":[{"name":"Institute of Pathology Klinikum Rechts der Isar Technical University of Munich Ismaningerstrasse 22 D\u201081675 Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Stolte","sequence":"additional","affiliation":[{"name":"Institute of Pathology Klinikum Bayreuth Preuschwitzerstrasse 101 D\u201095445 Bayreuth Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,2]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.265.10.1287"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)90420-H"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003\u20104975(97)01178\u20108"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098\u20102388(199707\/08)13:4<245::AID\u2010SSU5>3.0.CO;2\u20105"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889\u20108553(05)70306\u2010X"},{"key":"e_1_2_1_7_1","first-page":"3","article-title":"Esophageal cancer: screening and surveillance","volume":"9","author":"Stein HJ","year":"1996","journal-title":"Dis. 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