{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T18:08:32Z","timestamp":1780682912696,"version":"3.54.1"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2003,8,18]],"date-time":"2003-08-18T00:00:00Z","timestamp":1061164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2003,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>As in squamous cell esophageal cancer, the presence and number of lymph node metastases constitutes the major prognostic factor in patients with adenocarcinoma of the distal esophagus (the so\u2010called Barrett\u2019s cancer) who have had complete tumor resection (R0 resection). In contrast to squamous cell esophageal cancer, however, lymphatic spread in patients with Barrett\u2019s cancer appears to follow certain rules. Lymphatic spread is closely correlated with the pT category of the primary tumor; it starts only after infiltration of the basal membrane, and initially it is limited to the regional lymph nodes. Lymph node metastases at distant locations\u2014i.e., the upper mediastinum and the celiac axis\u2014are found almost exclusively in patients with multiple positive regional nodes. Skipping of regional lymph node stations occurs in less than 5% of the patients. These observations set the stage for individualized and tailored lymphadenectomy strategies. The sentinel lymphadenectomy concept may be applicable to patients with early Barrett\u2019s cancer.<\/jats:p>","DOI":"10.1007\/s00268-003-7060-2","type":"journal-article","created":{"date-parts":[[2003,11,19]],"date-time":"2003-11-19T20:53:30Z","timestamp":1069275210000},"page":"1052-1057","source":"Crossref","is-referenced-by-count":102,"title":["Pattern of Lymphatic Spread of Barrett\u2019s Cancer"],"prefix":"10.1002","volume":"27","author":[{"given":"Marcus","family":"Feith","sequence":"first","affiliation":[{"name":"Chirurgische Klinik und Poliklinik der Technischen Universit\u00e4t M\u00fcnchen Klinikum Rechts der Isar Ismaningerstrasse 22 D\u201081675 M\u00fcnchen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert J.","family":"Stein","sequence":"additional","affiliation":[{"name":"Chirurgische Klinik und Poliklinik der Technischen Universit\u00e4t M\u00fcnchen Klinikum Rechts der Isar Ismaningerstrasse 22 D\u201081675 M\u00fcnchen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. R\u00fcdiger","family":"Siewert","sequence":"additional","affiliation":[{"name":"Chirurgische Klinik und Poliklinik der Technischen Universit\u00e4t M\u00fcnchen Klinikum Rechts der Isar Ismaningerstrasse 22 D\u201081675 M\u00fcnchen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,8,18]]},"reference":[{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(94)70381-7"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010315)91:6<1098::AID-CNCR1105>3.0.CO;2-N"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199909000-00012"},{"key":"e_1_2_11_5_2","first-page":"289","article-title":"Current trends in the surgical treatment of esophageal and cardia adenocarcinoma","volume":"18","author":"Peracchia A","year":"1999","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2388(199707\/08)13:4<245::AID-SSU5>3.0.CO;2-5"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199211000-00010"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(94)90722-6"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10868"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(05)80275-2"},{"key":"e_1_2_11_11_2","first-page":"237","volume-title":"Prognostic Factors in Cancer","author":"Stein HJ","year":"2001"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010200011000\u201000017"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200109000-00010"},{"key":"e_1_2_11_14_2","first-page":"261","volume-title":"Gastrointestinal Oncology: Principles and Practice","author":"Siewert JR","year":"2002"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010200208000\u201000005"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(99)00122-0"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004230050184"},{"key":"e_1_2_11_18_2","volume-title":"International Union Against Cancer (UICC) (editors), TNM Classification of Malignant Tumors","author":"Sobin LH","year":"1997"},{"key":"e_1_2_11_19_2","volume-title":"American Joint Committee on Cancer Classification (AJCC) (editors), AJCC Cancer Staging Manual","author":"Fleming ID","year":"1997"},{"key":"e_1_2_11_20_2","first-page":"30","article-title":"Panel of Experts: Resective surgery for cancer of the thoracic esophagus","volume":"9","author":"Fumagalli U","year":"1996","journal-title":"Dis. Esoph."},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.1159\/000027165"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20001101)89:9<1874::AID-CNCR2>3.0.CO;2-M"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(99)70464-2"},{"key":"e_1_2_11_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(97)01387-8"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097\u20100142(20001101)89:9<1869::AID\u2010CNCR1>3.0.CO;2\u2010N"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2001.110024"},{"key":"e_1_2_11_27_2","first-page":"419","article-title":"Topographical distribution of lymph node metastasis in adenocarcinoma of the gastroesophageal junction","volume":"49","author":"Monig SP","year":"2002","journal-title":"Hepatogastroenterology."},{"key":"e_1_2_11_28_2","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2002.01.004"},{"key":"e_1_2_11_29_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.7.1970"},{"key":"e_1_2_11_30_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.2002.02065.x"},{"key":"e_1_2_11_31_2","first-page":"86S","article-title":"Laparoscopic detection of sentinel lymph nodes in gastrointestinal cancer: a novel and minimally invasive approach","volume":"8","author":"Kitagawa Y","year":"2001","journal-title":"Ann. Surg. Oncol."},{"key":"e_1_2_11_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004640090051"},{"key":"e_1_2_11_33_2","first-page":"191","article-title":"Individualized surgical strategies for cancer of the esophagogastric junction","volume":"89","author":"Stein HJ","year":"2000","journal-title":"Ann. Chir. Gynecol."},{"key":"e_1_2_11_34_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200012000-00002"},{"key":"e_1_2_11_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(05)70205-X"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-003-7060-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-003-7060-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-003-7060-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,24]],"date-time":"2023-12-24T09:43:41Z","timestamp":1703411021000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-003-7060-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,8,18]]},"references-count":34,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2003,9]]}},"alternative-id":["10.1007\/s00268-003-7060-2"],"URL":"https:\/\/doi.org\/10.1007\/s00268-003-7060-2","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,8,18]]}}}