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In a two\u2010institution study, the SLN procedure with isosulfan blue 1% was performed according to a standardized protocol in 31 patients with open resections for colon cancer. Data were collected prospectively. The database was analyzed retrospectively to determine factors contributing to a low identification rate. The SLN identification rate was 87% and the false negative rate was 50%. Successful SLN identification was significantly associated with application of higher volumes of dye relative to the tumor diameter (<jats:italic>p<\/jats:italic> = 0.04) and more frequent tumor localization in the sigmoid colon (<jats:italic>p<\/jats:italic> = 0.04) as compared to missing SLN identification. The tumor diameter was not significantly different in the two groups. Sentinel lymph node identification in colon cancer depends on the amount of dye injected relative to the tumor size. Application of only 1\u00a0ml of dye\u2014the amount generally recommended in the literature\u2014is not sufficient in large tumors.<\/jats:p>","DOI":"10.1007\/s00268-003-7086-5","type":"journal-article","created":{"date-parts":[[2004,7,22]],"date-time":"2004-07-22T00:55:38Z","timestamp":1090457738000},"page":"1285-1290","source":"Crossref","is-referenced-by-count":41,"title":["Identification of Sentinel Lymph Nodes in Colon Cancer Depends on the Amount of Dye Injected Relative to Tumor Size"],"prefix":"10.1002","volume":"27","author":[{"given":"Carsten T.","family":"Viehl","sequence":"first","affiliation":[{"name":"Department of Surgery Kantonsspital Olten Baslerstrasse 150 CH\u20104600 Olten Switzerland"},{"name":"Department of Surgery University of Basel CH\u20104031 Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian T.","family":"Hamel","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Basel CH\u20104031 Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter R.","family":"Marti","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Basel CH\u20104031 Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Guller","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Basel CH\u20104031 Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas","family":"Eisner","sequence":"additional","affiliation":[{"name":"Department of Surgery Kantonsspital Olten Baslerstrasse 150 CH\u20104600 Olten Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uz","family":"Stammberger","sequence":"additional","affiliation":[{"name":"Department of Surgery Kantonsspital Olten Baslerstrasse 150 CH\u20104600 Olten Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Terracciano","sequence":"additional","affiliation":[{"name":"Institute of Pathology University of Basel CH\u20104600 Olten Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans P.","family":"Spichtin","sequence":"additional","affiliation":[{"name":"Institut fuer Klinische Pathologie und Zytologie Basel Wartenbergstrasse 10 CH\u20104020 Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Harder","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Basel CH\u20104031 Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Zuber","sequence":"additional","affiliation":[{"name":"Department of Surgery Kantonsspital Olten Baslerstrasse 150 CH\u20104600 Olten Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,11,6]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096\u20109098(199803)67:3<194::AID\u2010JSO11>3.0.CO;2\u20102"},{"key":"e_1_2_7_3_2","volume-title":"American Joint Committee Cancer Staging Manual","author":"Fleming ID","year":"1997"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0011-3840(97)80013-5"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1245\/aso.2002.9.6.529"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-3656-4"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19940201)73:3<563::AID-CNCR2820730311>3.0.CO;2-D"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02049708"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711720205"},{"key":"e_1_2_7_10_2","first-page":"637","article-title":"Occurrence and prognostic importance of micrometastases in regional lymph nodes in Dukes\u2019 B colorectal carcinoma: an immunohistochemical study","volume":"162","author":"Adell G","year":"1996","journal-title":"Eur. 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