{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:00:26Z","timestamp":1792116026975,"version":"4.4.0"},"reference-count":62,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2003,10,27]],"date-time":"2003-10-27T00:00:00Z","timestamp":1067212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2003,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The apancreatic state secondary to resective surgery for chronic pancreatitis is associated with a high rate of late morbidity and mortality that is due, in part, to endocrine insufficiency. Resective procedures should, therefore, be used very selectively. Over the last 2 decades we have seen a shift from extensive distal resections to limited proximal resections. This is because of the lowering of the operative mortality of pancreatic head resection and its better results in pain relief, while preserving in situ the body and tail of the gland with its metabolic functions. Islet autotransplantation and segmental pancreatic autotransplantation were introduced in 1977 and 1978, respectively. Over 150 and 25 cases of these operations have been reported, respectively. Both techniques are evolving with a goal to improve results. Procedures placing the graft in the iliac fossa and anastomosing the pancreatic duct to the jejunum are now favored over groin placement and duct occlusion. Islet autotransplants achieve a higher yield of islet cells and decrease the exocrine impurity of the preparation. Both methods can prevent or delay the onset of diabetes mellitus, and when diabetes mellitus does occur, it is frequently easier to manage. The long\u2010term function of the grafts appears to be dependent on the \u03b2\u2010cell mass available in the diseased pancreas, the loss of cells related to the transplant procedure, and the characteristics of gradual loss of function from the type of transplant used. Although extensive pancreatic resections are occasionally required, the possibility of autotransplantation should be considered in those patients.<\/jats:p>","DOI":"10.1007\/s00268-003-7243-8","type":"journal-article","created":{"date-parts":[[2004,3,19]],"date-time":"2004-03-19T12:41:33Z","timestamp":1079700093000},"page":"1235-1240","source":"Crossref","is-referenced-by-count":17,"title":["Pancreatic Autotransplantation in Chronic Pancreatitis"],"prefix":"10.1002","volume":"27","author":[{"given":"J. Guillermo","family":"Watkins","sequence":"first","affiliation":[{"name":"Department of Surgery Universidad Cat\u00f3lica de Chile Santiago 764\u20100543 Chile"},{"name":"Hospital J. J. Aguirre Santos Dumont 999 Santiago 764\u20100543 Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred","family":"Krebs","sequence":"additional","affiliation":[{"name":"Department of Surgery Universidad Cat\u00f3lica de Chile Santiago 764\u20100543 Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo L.","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of Surgery Universidad de Chile Hospital J. J. Aguirre Santos Dumont 999 Santiago 764\u20100543 Chile"},{"name":"Surgeon Cl\u00ednica Alemana Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,10,27]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(16)43534-6"},{"key":"e_1_2_7_3_2","first-page":"162","volume-title":"Pancreatitis","author":"Rossi RL","year":"1989"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1993.01420210111015"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(81)90007-6"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01655072"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01670549"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198903000-00004"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199111000-00007"},{"key":"e_1_2_7_10_2","first-page":"820","article-title":"Course and outcome of chronic pancreatitis longitudinal study of a mixed medical\u2010surgical series of 245 patients","volume":"86","author":"Ammann RW","year":"1984","journal-title":"Gastroenterology"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102168.1998.00941.x"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-198705000-00017"},{"key":"e_1_2_7_13_2","first-page":"359","article-title":"Pancreatic autotransplantation following resection","volume":"83","author":"Hogle HH","year":"1978","journal-title":"Surgery"},{"key":"e_1_2_7_14_2","first-page":"15","article-title":"Segmental pancreas autotransplantation in man following total or near total pancreatectomy for serious recurrent chronic pancreatitis","volume":"12","author":"Tosatti E","year":"1980","journal-title":"Transplant. Proc."},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(83)90089-6"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198606000-00007"},{"key":"e_1_2_7_17_2","first-page":"111","article-title":"A clinical report of vascularized segmental pancreatic autotransplantation in chronic pancreatitis","volume":"87","author":"Tamura K","year":"1986","journal-title":"Nippon Geka Gakkai Zasshi."},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-198705000-00017"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(05)80606-3"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00311630"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198906000-00045"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198804000-00001"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(05)81142-0"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199002000-00014"},{"key":"e_1_2_7_25_2","first-page":"51","article-title":"Technical observations in segmental pancreas allografting. Observations on pancreatic blood flow","volume":"12","author":"Calne RY","year":"1980","journal-title":"Transplant. Proc."},{"key":"e_1_2_7_26_2","first-page":"40","article-title":"Pancreatic transplantation in man. Surgical technique and complications","volume":"12","author":"Dubernard JM","year":"1980","journal-title":"Transplant. Proc."},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)91616-7"},{"key":"e_1_2_7_28_2","first-page":"581","article-title":"A denervated pancreatic flap for control of chronic pain in pancreatitis","volume":"159","author":"Warren DW","year":"1984","journal-title":"Surg. Gynecol. Obstet."},{"key":"e_1_2_7_29_2","first-page":"321","article-title":"Absence of diabetes in dogs after total pancreatectomy and intrasplenic autotransplantation of pancreatic tissue","volume":"9","author":"Mirkovith V","year":"1997","journal-title":"Transplant. Proc."},{"key":"e_1_2_7_30_2","first-page":"336","article-title":"Human islet autotransplantation following pancreatectomy","volume":"11","author":"Najarian JS","year":"1979","journal-title":"Transplant. Proc."},{"key":"e_1_2_7_31_2","first-page":"581","article-title":"Long\u2010term follow\u2010up of human islet autotransplantation","volume":"26","author":"Fontana I","year":"1994","journal-title":"Transplant. Proc."},{"key":"e_1_2_7_32_2","first-page":"226","article-title":"A review of pancreatic islet autotransplantation","volume":"45","author":"Robertson G","year":"1998","journal-title":"Hepatogastroenterology."},{"key":"e_1_2_7_33_2","first-page":"238","article-title":"Bleeding esophageal varices and portal vein thrombosis after pancreatic mixed\u2010cell autotransplantation","volume":"95","author":"Memsic L","year":"1984","journal-title":"Surgery"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.46.1.23"},{"key":"e_1_2_7_35_2","first-page":"3529","article-title":"Body mass index is an important determinant for human islet isolation outcome","volume":"26","author":"Brandhorst D","year":"1994","journal-title":"Transplant. Proc."},{"key":"e_1_2_7_36_2","first-page":"829","article-title":"Islet cell autotransplantation: risks, complications, and long\u2010term follow\u2010up","volume":"16","author":"Toledo\u2010Pereyra LH","year":"1984","journal-title":"Transplant. Proc."},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-75319-0_67"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1996.01430150025004"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(80)90143-2"},{"key":"e_1_2_7_40_2","first-page":"608","article-title":"Chronic pancreatitis: long\u2010term surgical results of pancreatic duct drainage, pancreatic resection and near\u2010total pancreatectomy and islet autotransplantation","volume":"96","author":"Morrow CE","year":"1984","journal-title":"Surgery"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1159\/000171375"},{"key":"e_1_2_7_42_2","first-page":"307","article-title":"Pancreatic and islet autotransplantation","volume":"37","author":"Dafoe DC","year":"1990","journal-title":"Hepatogastroenterology."},{"key":"e_1_2_7_43_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010200103000\u201000018"},{"key":"e_1_2_7_44_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198306000-00006"},{"key":"e_1_2_7_45_2","first-page":"502","article-title":"Transplantation of irradiated heterotopic segmental human pancreas","volume":"49","author":"Tersigni R","year":"1983","journal-title":"Am. Surg."},{"key":"e_1_2_7_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(05)80606-3"},{"key":"e_1_2_7_47_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.29.1.S31"},{"key":"e_1_2_7_48_2","first-page":"485","article-title":"Portal hypertension, hepatic infarction, and liver failure complicating pancreatic islet autotransplantation","volume":"91","author":"Walsh TJ","year":"1982","journal-title":"Surgery"},{"key":"e_1_2_7_49_2","first-page":"801","article-title":"Pancreatic islet allograft prolongation by selective lymphoid irradiation (SLI), culture techniques, and ALG","volume":"13","author":"Reemtsma K","year":"1981","journal-title":"Transplant. Proc."},{"key":"e_1_2_7_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(81)80020-7"},{"key":"e_1_2_7_51_2","first-page":"590","article-title":"Transplantation register for pancreas and island of Langerhans","volume":"52","author":"Lorenz D","year":"1981","journal-title":"Chirurg"},{"key":"e_1_2_7_52_2","first-page":"2864","article-title":"Pancreatic transplantation: long\u2010term outcome of 21\u00a0grafts","volume":"21","author":"Valente U","year":"1989","journal-title":"Transplant. Proc."},{"key":"e_1_2_7_53_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1981.01380170009002"},{"key":"e_1_2_7_54_2","first-page":"91","article-title":"Allotransplantation of neonatal pancreas\u2010microfragments in man","volume":"13","author":"Dobroschke J","year":"1983","journal-title":"Horm. Metab. Res. Suppl."},{"key":"e_1_2_7_55_2","first-page":"175","article-title":"Islets of Langerhans and pancreas transplantation tomorrow","volume":"20","author":"Altman JJ","year":"1994","journal-title":"Diabete. Metab."},{"key":"e_1_2_7_56_2","first-page":"43","article-title":"A case of autotransplantation of microfragments of endocrine tissue of the pancreas after its subtotal resection","volume":"33","author":"Potashov LV","year":"1987","journal-title":"Probl. Endokrinol. (Mosk)."},{"key":"e_1_2_7_57_2","first-page":"2744","article-title":"Human islet transplantation in patients with type I diabetes","volume":"21","author":"Scharp D","year":"1989","journal-title":"Transplant. Proc."},{"key":"e_1_2_7_58_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199112000-00026"},{"key":"e_1_2_7_59_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-115-9-694"},{"key":"e_1_2_7_60_2","first-page":"3525","article-title":"Efficiency of highly purified islets autotransplanted into the portal vein after total pancreatectomy","volume":"26","author":"Hesse UJ","year":"1994","journal-title":"Transplant. Proc."},{"key":"e_1_2_7_61_2","first-page":"3521","article-title":"Delayed islet autotransplantation after total pancreatectomy","volume":"26","author":"Arias\u2010Diaz J","year":"1994","journal-title":"Transplant. Proc."},{"key":"e_1_2_7_62_2","first-page":"263","article-title":"Clinical studies of human islet transplantation","volume":"77","author":"London NJ","year":"1995","journal-title":"Ann. R. Coll. Surg. Engl."},{"key":"e_1_2_7_63_2","first-page":"223","article-title":"Total pancreatectomy for chronic pancreatitis","volume":"160","author":"Kiviluoto T","year":"1985","journal-title":"Surg. Gynecol. Obstet."}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-003-7243-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-003-7243-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-003-7243-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T12:36:18Z","timestamp":1703594178000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-003-7243-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,10,27]]},"references-count":62,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2003,11]]}},"alternative-id":["10.1007\/s00268-003-7243-8"],"URL":"https:\/\/doi.org\/10.1007\/s00268-003-7243-8","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,10,27]]}}}