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Markers chosen for evaluation included the apoptosis\u2010associated gene products (p53 and bcl\u20102), a tumor proliferation activity\u2010related factor (Ki\u201067), and the markers (MLH1 and MSH2) of DNA microsatellite instability (MSI). Results were correlated with age and the stage and location of the tumor. The average age of the early\u2010onset group was 30.7 years compared to the late\u2010onset group at 67.0 years; and the male\/female ratio was equivalent. The younger patients had a significantly higher Dukes\u2019 stage, the tumors were more poorly differentiated, and they were more frequently of the mucinous and signet ring cell histopathologic type. Expression of p53 was higher in the younger patients (<jats:italic>p<\/jats:italic> &lt; 0.001) and was independent of the degree of differentiation or the stage of the tumor. No differences of expression were noted for the other markers measured. The increased frequency of CRC in Filipino patients less than 40 years of age offers a unique opportunity to gain a better understanding of carcinogenesis, which might be exploited during diagnosis and management. The differences noted between the early\u2010 and late\u2010onset CRC are provocative and provide an impetus for increased screening in Filipinos.<\/jats:p>","DOI":"10.1007\/s00268-003-7281-4","type":"journal-article","created":{"date-parts":[[2004,3,3]],"date-time":"2004-03-03T22:35:10Z","timestamp":1078353310000},"page":"117-123","source":"Crossref","is-referenced-by-count":11,"title":["Clinical and molecular biologic characteristics of early\u2010onset versus late\u2010onset colorectal carcinoma in Filipinos"],"prefix":"10.1002","volume":"28","author":[{"given":"Gemma B.","family":"Uy","sequence":"first","affiliation":[{"name":"Department of Surgery Uniformed Services University of the Health Sciences 4301\u00a0Jones Bridge Road 29814\u20104799 Maryland Bethesda USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leoncio L.","family":"Kaw","sequence":"additional","affiliation":[{"name":"Department of Surgery Uniformed Services University of the Health Sciences 4301\u00a0Jones Bridge Road 29814\u20104799 Maryland Bethesda USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corazon K.","family":"Punzalan","sequence":"additional","affiliation":[{"name":"Division of Colorectal Surgery University of the Philippines\u2010Philippine General Hospital Taft Avenue 1100 Manila Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R Ireneo Luis C.","family":"Querol","sequence":"additional","affiliation":[{"name":"Department of Surgery Uniformed Services University of the Health Sciences 4301\u00a0Jones Bridge Road 29814\u20104799 Maryland Bethesda USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena V.","family":"Koustova","sequence":"additional","affiliation":[{"name":"Department of Surgery Uniformed Services University of the Health Sciences 4301\u00a0Jones Bridge Road 29814\u20104799 Maryland Bethesda USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark W.","family":"Bowyer","sequence":"additional","affiliation":[{"name":"Department of Surgery Uniformed Services University of the Health Sciences 4301\u00a0Jones Bridge Road 29814\u20104799 Maryland Bethesda USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine M.","family":"Hobbs","sequence":"additional","affiliation":[{"name":"Gastrointestinal Section Armed Forces Institute of Pathology 20307 Maryland Bethesda USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie H.","family":"Sobin","sequence":"additional","affiliation":[{"name":"Gastrointestinal Section Armed Forces Institute of Pathology 20307 Maryland Bethesda USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David C.","family":"Wherry","sequence":"additional","affiliation":[{"name":"Department of Surgery Uniformed Services University of the Health Sciences 4301\u00a0Jones Bridge Road 29814\u20104799 Maryland Bethesda USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,2]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"20","volume-title":"Cancer Facts and Figures 2002, Surveillance Research","year":"2002"},{"key":"e_1_2_1_3_1","first-page":"9","article-title":"Philippine Cancer Facts and Estimates, Manila","volume":"1998","author":"Laudico AV","year":"1998","journal-title":"Philippine Cancer Society"},{"key":"e_1_2_1_4_1","first-page":"563","article-title":"Colorectal cancer in patients under forty: presentation and outcome","volume":"64","author":"Parramore JB","year":"1998","journal-title":"Am. 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