{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:43:22Z","timestamp":1793321002127,"version":"4.5.0"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,2,17]],"date-time":"2004-02-17T00:00:00Z","timestamp":1076976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM 27345"],"award-info":[{"award-number":["GM 27345"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2004,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Postoperative peritoneal adhesions are common and serious complications of general abdominal and gynecological surgery that can lead to chronic abdominal pain, small\u2010bowel obstruction and infertility. The specific pathophysiology of peritoneal adhesions remains elusive and current treatment is relegated to prevention through meticulous surgical technique and protective physical barriers, gels and solutions. We have reported that reactive oxygen species (ROS), generated by phagocytic cells at the site of tissue injury, serve as major signaling molecules regulating the expression of vascular endothelial growth factor (VEGF) and subsequent wound repair. We hypothesized that peritoneal adhesions are a product of over\u2010healing surgical wounds and that, like in wound healing, ROS are implicated in their pathogenesis. We examined the presence of footprints of ROS and the ROS\u2010inducible angiogenic factor VEGF in human adhesion tissue. An experimental model of peritoneal adhesion was established in rodents to study of the dynamics of ROS\u2010induced gene expression during de novo adhesion tissue formation. Immunohistochemical analysis demonstrated presence of ROS\/oxidant and macrophages in human peritoneal tissue. The presence of ROS and ROS\u2010sensitive transcription factor EGR\u20101 was also evident in an experimental rodent peritoneal adhesion model. Along with ROS, VEGF, and a large number of mature and immature CD31\/vWF positive blood vessels were present in the adhesion tissue. These observations are not consistent with the contention that adhesions are non\u2010functional scar tissue. The newly developed rodent model of adhesion may present a useful approach to reproducibly and objectively study molecular mechanisms underlying the dynamic process of de novo adhesion tissue formation.<\/jats:p>","DOI":"10.1007\/s00268-003-7403-z","type":"journal-article","created":{"date-parts":[[2004,3,29]],"date-time":"2004-03-29T16:38:18Z","timestamp":1080578298000},"page":"316-320","source":"Crossref","is-referenced-by-count":30,"title":["Reactive Oxygen Species and EGR\u20101 Gene Expression in Surgical Postoperative Peritoneal Adhesions"],"prefix":"10.1002","volume":"28","author":[{"given":"Sashwati","family":"Roy","sequence":"first","affiliation":[{"name":"Department of Surgery, Center for Minimally Invasive Surgery, Laboratory of Molecular Medicine, Davis Heart &amp; Lung Research Institute The Ohio State University 473 W. 12th Avenue Columbus Ohio 73210 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clancy J.","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Surgery, Center for Minimally Invasive Surgery, Laboratory of Molecular Medicine, Davis Heart &amp; Lung Research Institute The Ohio State University 473 W. 12th Avenue Columbus Ohio 73210 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khashayar","family":"Mohebali","sequence":"additional","affiliation":[{"name":"Department of Surgery, Center for Minimally Invasive Surgery, Laboratory of Molecular Medicine, Davis Heart &amp; Lung Research Institute The Ohio State University 473 W. 12th Avenue Columbus Ohio 73210 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udayan","family":"Bhatt","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology The Ohio State University 473 W. 12th Avenue Columbus Ohio 43210 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A.","family":"Wallace","sequence":"additional","affiliation":[{"name":"Department of Surgery, Center for Minimally Invasive Surgery, Laboratory of Molecular Medicine, Davis Heart &amp; Lung Research Institute The Ohio State University 473 W. 12th Avenue Columbus Ohio 73210 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. Stanley","family":"Nahman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology The Ohio State University 473 W. 12th Avenue Columbus Ohio 43210 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Christopher","family":"Ellison","sequence":"additional","affiliation":[{"name":"Department of Surgery, Center for Minimally Invasive Surgery, Laboratory of Molecular Medicine, Davis Heart &amp; Lung Research Institute The Ohio State University 473 W. 12th Avenue Columbus Ohio 73210 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Scott","family":"Melvin","sequence":"additional","affiliation":[{"name":"Department of Surgery, Center for Minimally Invasive Surgery, Laboratory of Molecular Medicine, Davis Heart &amp; Lung Research Institute The Ohio State University 473 W. 12th Avenue Columbus Ohio 73210 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandan K.","family":"Sen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Center for Minimally Invasive Surgery, Laboratory of Molecular Medicine, Davis Heart &amp; Lung Research Institute The Ohio State University 473 W. 12th Avenue Columbus Ohio 73210 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,2,17]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000050149"},{"key":"e_1_2_8_3_2","first-page":"60","article-title":"Intestinal obstruction from adhesions\u07ddhow big is the problem?","volume":"72","author":"Menzies D","year":"1990","journal-title":"Ann. 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Reprod. Med."},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/1096\u20109896(2000)9999:9999<::AID\u2010PATH678>3.3.CO;2\u20105"},{"key":"e_1_2_8_18_2","first-page":"117","article-title":"Postoperative peritoneal adhesions","volume":"65","author":"Ryan GB","year":"1971","journal-title":"Am. J. Pathol."},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107236"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm905"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.3109\/07853890109002083"},{"key":"e_1_2_8_22_2","first-page":"119","article-title":"Nonsteroidal anti\u2010inflammatory drugs (NSAIDs) in the treatment of postsurgical adhesion","volume":"358","author":"Rodgers KE","year":"1990","journal-title":"Prog. Clin. Biol. 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