{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T11:25:27Z","timestamp":1765279527882},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,4,19]],"date-time":"2004-04-19T00:00:00Z","timestamp":1082332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Free malignant cells, which are frequently detected in the washing liquid from the peritoneal cavity before and after resection of human colorectal cancer, are suspected to cause recurrent peritoneal cancer. We carried out an experimental study to compare the prophylactic efficacy of washing the peritoneum with several anticancer drugs and the antiseptic povidone\u2010iodine against the development of peritoneal carcinomatosis from colonic origin in rats and nude mice. The in vitro anticancer activity of a short, 15\u2010minute exposure of pirarubicin, doxorubicin, 5\u2010fluorouracil, cisplatin, mitomycin C, and 1% povidone\u2010iodine was first evaluated by an MTT assay on DHD\/K12\/PROb rat and LS174T human colon cancer cells. For the in vivo experiments<jats:italic>,<\/jats:italic> BDIX rats were inoculated intraperitoneally (IP) with 1 x 10<jats:sup>6<\/jats:sup> DHD\/K12\/PROb cells followed by peritoneal scarring and a colocolic anastomosis. A 15\u2010minute peritoneal washing with the anticancer drugs or povidone\u2010iodine was then performed. Nude mice were IP\u2010inoculated with 1 \u00d7 10<jats:sup>7<\/jats:sup> LS174T human cells and treated 2 hours later with IP pirarubicin. Only pirarubicin, mitomycin C, and povidone\u2010iodine were fully cytotoxic in vitro against DHD\/K12\/PROb rat colon cancer cells. In contrast to pirarubicin and povidone\u2010iodine, mitomycin C was not completely active against LS174Tcells. In vivo, pirarubicin cured DHD\/K12\/PROb\u2010inoculated rats, even at the site of the peritoneal scarring and intestinal anastomosis. IP pirarubicin prevented the development of peritoneal carcinomatosis and liver metastasis in LS174T\u2010inoculated mice. IP washing with pirarubicin cured 2\u2010day\u2010old, but not 7\u2010day\u2010old, peritoneal carcinomatosis in rats. Short exposure to IP pirarubicin is nontoxic and more active than povidone\u2010iodine and other anticancer drugs in preventing the development of peritoneal carcinomatosis from colonic origin in rats and mice. The prophylactic effect of preoperative peritoneal washing with pirarubicin on the development of recurrent peritoneal cancer should be evaluated in a randomized clinical trial.<\/jats:p>","DOI":"10.1007\/s00268-004-6927-1","type":"journal-article","created":{"date-parts":[[2004,4,15]],"date-time":"2004-04-15T20:39:18Z","timestamp":1082061558000},"page":"451-456","source":"Crossref","is-referenced-by-count":8,"title":["Prevention of Peritoneal Carcinomatosis from Colon Cancer Cell Seeding Using a Pirarubicin Solution in Rats and Nude Mice"],"prefix":"10.1002","volume":"28","author":[{"given":"Patrick","family":"Favoulet","sequence":"first","affiliation":[{"name":"Unit\u00e9 INSERM 517, Faculty of Medicine 7 Bd Jeanne d\u2019Arc 21000 Dijon France"},{"name":"Department of Visceral, Thoracic and Oncologic Surgery University Hospital 1 Bd Mal Lattre de Tassigny 21000 Dijon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Benoit","sequence":"additional","affiliation":[{"name":"Unit\u00e9 INSERM 517, Faculty of Medicine 7 Bd Jeanne d\u2019Arc 21000 Dijon France"},{"name":"Regional Anticancer Centre 1 Rue du Pr Marion 21000 Dijon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliana","family":"Osmak","sequence":"additional","affiliation":[{"name":"Unit\u00e9 INSERM 517, Faculty of Medicine 7 Bd Jeanne d\u2019Arc 21000 Dijon France"},{"name":"Department of Visceral, Thoracic and Oncologic Surgery University Hospital 1 Bd Mal Lattre de Tassigny 21000 Dijon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Polycarpe","sequence":"additional","affiliation":[{"name":"Unit\u00e9 INSERM 517, Faculty of Medicine 7 Bd Jeanne d\u2019Arc 21000 Dijon France"},{"name":"Department of Visceral, Thoracic and Oncologic Surgery University Hospital 1 Bd Mal Lattre de Tassigny 21000 Dijon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Esquis","sequence":"additional","affiliation":[{"name":"Unit\u00e9 INSERM 517, Faculty of Medicine 7 Bd Jeanne d\u2019Arc 21000 Dijon France"},{"name":"Department of Visceral, Thoracic and Oncologic Surgery University Hospital 1 Bd Mal Lattre de Tassigny 21000 Dijon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Duvillard","sequence":"additional","affiliation":[{"name":"Unit\u00e9 INSERM 517, Faculty of Medicine 7 Bd Jeanne d\u2019Arc 21000 Dijon France"},{"name":"Department of Head and Neck Surgery University Hospital Bd Faubourg Raynes 21000 Dijon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris","family":"Guiu","sequence":"additional","affiliation":[{"name":"Unit\u00e9 INSERM 517, Faculty of Medicine 7 Bd Jeanne d\u2019Arc 21000 Dijon France"},{"name":"Department of Visceral, Thoracic and Oncologic Surgery University Hospital 1 Bd Mal Lattre de Tassigny 21000 Dijon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Rat","sequence":"additional","affiliation":[{"name":"Department of Visceral, Thoracic and Oncologic Surgery University Hospital 1 Bd Mal Lattre de Tassigny 21000 Dijon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Pierre","family":"Favre","sequence":"additional","affiliation":[{"name":"Department of Visceral, Thoracic and Oncologic Surgery University Hospital 1 Bd Mal Lattre de Tassigny 21000 Dijon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Chauffert","sequence":"additional","affiliation":[{"name":"Unit\u00e9 INSERM 517, Faculty of Medicine 7 Bd Jeanne d\u2019Arc 21000 Dijon France"},{"name":"Regional Anticancer Centre 1 Rue du Pr Marion 21000 Dijon France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,4,19]]},"reference":[{"key":"e_1_2_8_2_2","first-page":"83","article-title":"Rationale for integrating early postoperative intraperitoneal chemotherapy into the surgical treatment of gastrointestinal cancer","volume":"16","author":"Sugarbaker PH","year":"1989","journal-title":"Semin. 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