{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T05:06:48Z","timestamp":1761109608493},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,5,19]],"date-time":"2004-05-19T00:00:00Z","timestamp":1084924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The efficacy of technetium\u201099m methoxyisobutylisonitrile (<jats:sup>99m<\/jats:sup>Tc\u2010MIBI)\u2010guided surgery for detecting abnormal parathyroid glands in patients with secondary hyperparathyroidism (2\u2010HPT) was evaluated and compared with the results from the same examination in patients with primary hyperparathyroidism (1\u2010HPT). The results were also compared with those found by ultrasonography (US) and preoperative <jats:sup>99m<\/jats:sup>Tc\u2010MIBI scintigraphy was also made. At operation <jats:sup>99m<\/jats:sup>Tc\u2010MIBI accumulated in 64\u00a0nodules of 15 cases of 2\u2010HPT, and all of 60 parathyroid swellings were detected (true\u2010positives 60, sensitivity 100%, accuracy 94%). In the cases of 1\u2010HPT, <jats:sup>99m<\/jats:sup>Tc\u2010MIBI revealed 11 hot nodules in 10 cases, and the evaluation was true\u2010positive 10, sensitivity 100%, and accuracy 91%. US and preoperative <jats:sup>99m<\/jats:sup>Tc\u2010MIBI scintigraphy in patients with 2\u2010HPT had a sensitivity of 75% and 67% and an accuracy of 70% and 66%, respectively. The usefulness of <jats:sup>99m<\/jats:sup>Tc\u2010MIBI\u2010guided surgery for detecting abnormal parathyroid tissue in 2\u2010HPT patients was similar to that in 1\u2010HPT patients but was superior to US and preoperative <jats:sup>99m<\/jats:sup>Tc\u2010MIBI scintigraphy. Intraoperative <jats:sup>9m<\/jats:sup>Tc\u2010MIBI for patients with 2\u2010HPT is effective and makes the surgery easier, especially when the parathyroid glands are ectopic or when a few glands are markedly enlarged but the other glands are atrophied.<\/jats:p>","DOI":"10.1007\/s00268-004-7227-5","type":"journal-article","created":{"date-parts":[[2004,5,14]],"date-time":"2004-05-14T20:45:48Z","timestamp":1084567548000},"page":"576-582","source":"Crossref","is-referenced-by-count":17,"title":["Usefulness of Radio\u2010guided Surgery Using Technetium\u201099m Methoxyisobutylisonitrile for Primary and Secondary Hyperparathyroidism"],"prefix":"10.1002","volume":"28","author":[{"given":"Hiroshi","family":"Takeyama","sequence":"first","affiliation":[{"name":"Department of Surgery Jikei University School of Medicine 3\u201025\u20108 Nishi\u2010sinbashi 105\u20108461 Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisashi","family":"Shioya","sequence":"additional","affiliation":[{"name":"Department of Surgery Jikei University School of Medicine 3\u201025\u20108 Nishi\u2010sinbashi 105\u20108461 Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Radiology Jikei University School of Medicine 3\u201025\u20108 Nishi\u2010sinbashi 105\u20108461 Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeyuki","family":"Ogi","sequence":"additional","affiliation":[{"name":"Department of Radiology Jikei University School of Medicine 3\u201025\u20108 Nishi\u2010sinbashi 105\u20108461 Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyasu","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Jikei University School of Medicine 3\u201025\u20108 Nishi\u2010sinbashi 105\u20108461 Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naohiko","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Jikei University School of Medicine 3\u201025\u20108 Nishi\u2010sinbashi 105\u20108461 Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoki","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"Department of Surgery Jikei University School of Medicine 3\u201025\u20108 Nishi\u2010sinbashi 105\u20108461 Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Surgery Jikei University School of Medicine 3\u201025\u20108 Nishi\u2010sinbashi 105\u20108461 Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Surgery Jikei University School of Medicine 3\u201025\u20108 Nishi\u2010sinbashi 105\u20108461 Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoji","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Department of Surgery Jikei University School of Medicine 3\u201025\u20108 Nishi\u2010sinbashi 105\u20108461 Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,5,19]]},"reference":[{"key":"e_1_2_8_2_2","first-page":"1646","article-title":"Effect of mitochondrial and plasma membrane potentials on accumulation of hexakis (2\u2010methoxyisobutylisonitrile) technetium(I) in cultured mouse fibroblast","volume":"31","author":"Chiu LM","year":"1990","journal-title":"J. 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