{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T18:27:40Z","timestamp":1787855260013,"version":"build-2784847793"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2004,9,29]],"date-time":"2004-09-29T00:00:00Z","timestamp":1096416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2004,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Little is known about the relation between liver regeneration and splenic size. We monitored serial changes in liver and spleen volumes using computed tomography in 24 patients with biliary cancer who underwent right hepatectomy or more extensive liver resection following portal vein embolization (PVE). Nonembolized hepatic segments increased in volume from 316 \u00b1 97\u00a0cm<jats:sup>3<\/jats:sup> (34% \u00b1 8% of total liver volume) before PVE to 410 \u00b1 115\u00a0cm<jats:sup>3<\/jats:sup> (44% \u00b1 8%) after PVE. The volume of nonembolized hepatic segments (i.e., remnant liver) increased to 617 \u00b1 111\u00a0cm<jats:sup>3<\/jats:sup> (59% \u00b1 10% of total liver volume before PVE) 14\u00a0days after hepatectomy and then increased slowly to reach 795 \u00b1 231\u00a0cm<jats:sup>3<\/jats:sup> (76% \u00b1 16%) 1 year after hepatectomy. Splenic volume increased from 87 \u00b1 29\u00a0cm<jats:sup>3<\/jats:sup> before PVE to 104 \u00b1 38\u00a0cm<jats:sup>3<\/jats:sup> (119% \u00b1 17% of original volume) after PVE. Splenic volume increased to 137 \u00b1 65\u00a0cm<jats:sup>3<\/jats:sup> (155% \u00b1 40%) by 14\u00a0days after hepatectomy and to 155 \u00b1 67\u00a0cm<jats:sup>3<\/jats:sup> (179% \u00b1 41%) by 28\u00a0days after hepatectomy, with no further change at 1 year after hepatectomy (153 \u00b1 92\u00a0cm<jats:sup>3<\/jats:sup>; 174% \u00b1 79%). The rate of increase in splenic volume within the first 14\u00a0days after hepatectomy was 2.7 \u00b1 3.6\u00a0cm<jats:sup>3<\/jats:sup>\/day, correlating well with increases in remnant liver volume (<jats:italic>r<\/jats:italic> = 0.64, <jats:italic>p<\/jats:italic> = 0.0006). These data indicate that the spleen is enlarged during liver regeneration, suggesting that the liver and spleen share certain common growth regulatory mechanisms.<\/jats:p>","DOI":"10.1007\/s00268-004-7435-z","type":"journal-article","created":{"date-parts":[[2004,10,2]],"date-time":"2004-10-02T03:41:56Z","timestamp":1096688516000},"page":"977-981","source":"Crossref","is-referenced-by-count":22,"title":["Changes in Splenic Volume during Liver Regeneration"],"prefix":"10.1002","volume":"28","author":[{"given":"Hideya","family":"Ando","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology Nagoya University Graduate School of Medicine 466\u20108550 Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Nagino","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology Nagoya University Graduate School of Medicine 466\u20108550 Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Arai","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology Nagoya University Graduate School of Medicine 466\u20108550 Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Nishio","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology Nagoya University Graduate School of Medicine 466\u20108550 Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Nimura","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology Nagoya University Graduate School of Medicine 466\u20108550 Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,9,29]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198707000-00005"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0270\u20109139(93)90510\u2010T"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00309384"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01211346"},{"key":"e_1_2_8_6_2","first-page":"364","article-title":"Liver regeneration after extended right hemihepatectomy in patients with hilar or diffuse bile duct carcinoma","volume":"46","author":"Miyagawa S","year":"1999","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0007\u20101323.2001.01832.x"},{"key":"e_1_2_8_8_2","first-page":"248","article-title":"Role of the spleen in regeneration of the liver: an experimental study","volume":"7","author":"Perez\u2010Tamayo R","year":"1958","journal-title":"Lab. 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