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Multivariate analysis found that the following were risk factors for surgical mortality: \u03b3\u2010glutamyltransferase level &gt; 75 UI\/ml (<jats:italic>p<\/jats:italic>= 0.007), weight loss = 10% (<jats:italic>p<\/jats:italic>= 0.05), and digestive toxicity World Health Organization grade III or IV during PRCT (<jats:italic>p<\/jats:italic>= 0.019). The median overall survival was 24.9\u00a0months. The 5\u2010year overall survival (OS) and disease\u2010free survival (DFS) were, respectively, 33.1% and 33.2%. Complete responder patients had a 71.8% 5\u2010year OS (<jats:italic>p<\/jats:italic>= 0.01) and a 71.8% 5\u2010year DFS (<jats:italic>p<\/jats:italic>= 0.009). The rate of recurrence was 37.5%. Multivariate analysis found that female gender (<jats:italic>p<\/jats:italic>= 0.03), weight loss = 10% (<jats:italic>p<\/jats:italic>= 0.03), preoperative computed tomography scan bronchial contact (<jats:italic>p<\/jats:italic>= 0.01), and N+ status (pN+) at pathology examination (<jats:italic>p<\/jats:italic>= 0.0001) were predictors of poor oncologic results. Patients with high preoperative risk of surgical mortality need to be selected for intensive perioperative management. In association with surgery, PRCT improves the local control, DFS, and OS of responder patients. Morphologic evaluation for staging esophageal cancer in predicting the pathologic response after PRCT is poor or controversial. Only surgical resection can provide accurate prognostic information for staging esophageal cancer and improving local control.<\/jats:p>","DOI":"10.1007\/s00268-004-7455-8","type":"journal-article","created":{"date-parts":[[2005,2,22]],"date-time":"2005-02-22T10:32:47Z","timestamp":1109068367000},"page":"32-38","source":"Crossref","is-referenced-by-count":4,"title":["Surgery for Esophageal Cancer after Concomitant Radiochemotherapy: Oncologic and Functional Results"],"prefix":"10.1002","volume":"29","author":[{"given":"Nicolas","family":"Plaisant","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology Centre Regional de Lutte Centre le Cancer 208 Rue des Apothicaires, Parc Euromedecine 34298 Montpellier, Cedex 5 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Senesse","sequence":"additional","affiliation":[{"name":"Department of Medical Digestive Oncology Centre Regional de Lutte Centre le Cancer 208 Rue des Apothicaires, Parc Euromedecine 34298 Montpellier, Cedex 5 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Azria","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy Centre Regional de Lutte Contre le Cancer 208 Rue des Apothicaires, Parc Euromedecine 34298 Montpellier, Cedex 5 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Lemanski","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy Centre Regional de Lutte Contre le Cancer 208 Rue des Apothicaires, Parc Euromedecine 34298 Montpellier, Cedex 5 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Ychou","sequence":"additional","affiliation":[{"name":"Department of Medical Digestive Oncology Centre Regional de Lutte Centre le Cancer 208 Rue des Apothicaires, Parc Euromedecine 34298 Montpellier, Cedex 5 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francois","family":"Quenet","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Centre Regional de Lutte Centre le Cancer 208 Rue des Apothicaires, Parc Euromedecine 34298 Montpellier, Cedex 5 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Saint\u2010Aubert","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Centre Regional de Lutte Centre le Cancer 208 Rue des Apothicaires, Parc Euromedecine 34298 Montpellier, Cedex 5 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Rouanet","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Centre Regional de Lutte Centre le Cancer 208 Rue des Apothicaires, Parc Euromedecine 34298 Montpellier, Cedex 5 France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,12,9]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800670602"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800770804"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800830134"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/ejso.1999.0929"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02067069"},{"key":"e_1_2_7_7_2","first-page":"690","article-title":"Preoperative radiotherapy for carcinoma of the esophagus","volume":"153","author":"Launois B","year":"1981","journal-title":"Surg. 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