{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T03:30:30Z","timestamp":1768966230439,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,1,20]],"date-time":"2005-01-20T00:00:00Z","timestamp":1106179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2005,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Few studies have reported the incidence and clinical outcomes of gallstone disease after extended (D2) lymph node dissection for gastric cancer. The present study was designed to retrospectively compare limited (D1) and D2 dissections in terms of gallstone formation, presentation of gallstones, and surgery for gallstone disease. A total of 805\u00a0Japanese gastric cancer patients (595\u00a0male, 210 female) who underwent curative resection with D1 (<jats:italic>n<\/jats:italic> = 490) or D2 (<jats:italic>n<\/jats:italic><jats:italic>=<\/jats:italic> 315) dissection were retrospectively reviewed. Of those subjects followed for 70.5 \u00b1 44.3\u00a0months (range: 2\u2010196\u00a0months), 102 (12.7%) developed gallstones. The incidence of gallstone formation was higher in the D2\u00a0group than in the D1\u00a0group (17.8% vs. 9.4%, <jats:italic>p<\/jats:italic><jats:italic>=<\/jats:italic> 0.001). The interval between gastrectomy and detection of gallstones was shorter in the D2\u00a0group than in the Dl group (18.8 \u00b1 11.4\u00a0months vs. 29.4 \u00b1 18.3\u00a0months, <jats:italic>p<\/jats:italic> = 0.002). Of those with gallstones followed for 48.0 \u00b1 28.6\u00a0months (range: 1\u2010158\u00a0months), 74 (72.5%) remained asymptomatic, and 15 (14.7%) experienced mild biliary pain. Thirteen patients (12.7%) developed recurrent biliary pain (<jats:italic>n<\/jats:italic> = 3) or biliary complications (<jats:italic>n<\/jats:italic> = 10; 6 acute cholecystitis, 3 obstructive jaundice, and 1 cholangitis), and required surgical treatment. Surgery was more frequently sought in the D2\u00a0group than in the D1\u00a0group (19.5% vs. 4.3%, <jats:italic>p<\/jats:italic> = 0.033). In conclusion, patients with D2 dissection developed gallstones more frequently and earlier than patients with D1 dissection. Of those with gallstones, patients with D2 dissection required surgery more often than patients with D1 dissection. A closer follow\u2010up should be mandatory for gallstone disease after D2 dissection, but further studies are needed before generalizations can be made.<\/jats:p>","DOI":"10.1007\/s00268-004-7482-5","type":"journal-article","created":{"date-parts":[[2005,1,15]],"date-time":"2005-01-15T16:44:55Z","timestamp":1105807495000},"page":"182-186","source":"Crossref","is-referenced-by-count":45,"title":["Gallstone Disease after Extended (D2) Lymph Node Dissection for Gastric Cancer"],"prefix":"10.1002","volume":"29","author":[{"given":"Tomotaka","family":"Akatsu","sequence":"first","affiliation":[{"name":"Department of Surgery Keio University School of Medicine 35 Shinanomachi 160\u20108582 Shinjyuku\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Surgery Keio University School of Medicine 35 Shinanomachi 160\u20108582 Shinjyuku\u2010ku Tokyo 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