{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:57:15Z","timestamp":1785891435098,"version":"3.56.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,1,20]],"date-time":"2005-01-20T00:00:00Z","timestamp":1106179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2005,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Most commercial assays for intact parathyroid hormone (iPTH) cross\u2010react with non\u2010PTH1\u201084 fragments (likely to be PTH7\u201084). We aimed to evaluate a whole PTH assay that measured only PTH1\u201084 by comparing it with an assay measuring iPTH levels during parathyroidectomy in secondary hyperparathyroidism (HPT). Twenty\u2010eight patients with secondary HPT who underwent total parathyroidectomy with autotransplantation served as subjects. Blood samples for postoperative assay were drawn after anesthesia; immediately prior to excision of the last parathyroid gland; and at 5, 10, and 15\u00a0minutes after excision. The PTH7\u201084 level was calculated by subtracting the whole PTH value from the iPTH value. Plasma whole PTH decreased more rapidly than iPTH after parathyroidectomy (<jats:italic>p<\/jats:italic> &lt; 0.0001). PTH levels that decreased by 50% or more from levels prior to excision to 10\u00a0minutes after excision were used to predict successful parathyroidectomy; decreases in whole PTH substantiated curative surgery for all patients without introducing false\u2010positive and false\u2010negative results. iPTH levels decreased by at least 50% in only 16 patients at 10\u00a0minutes after excision without false\u2010positive results. Out of 11 cases in which iPTH decreased less than 50%, two were true\u2010negatives and nine were false\u2010negatives. Decreases in whole PTH levels more accurately reflect surgical outcome than do decreases in iPTH levels during parathyroidectomy in secondary HPT patients. Even though the quick iPTH assay is used infrequently during surgery for secondary HPT, our results suggest that a quick whole PTH assay may be more useful than the iPTH assay currently used in parathyroidectomy procedures for secondary HPT.<\/jats:p>","DOI":"10.1007\/s00268-004-7489-y","type":"journal-article","created":{"date-parts":[[2005,1,13]],"date-time":"2005-01-13T08:51:31Z","timestamp":1105606291000},"page":"169-173","source":"Crossref","is-referenced-by-count":24,"title":["Sequential Changes in Plasma Intact and Whole Parathyroid Hormone Levels during Parathyroidectomy for Secondary Hyperparathyroidism"],"prefix":"10.1002","volume":"29","author":[{"given":"Hiroyuki","family":"Yamashita","sequence":"first","affiliation":[{"name":"Noguchi Thyroid Clinic and Hospital Foundation 6\u201033 Noguchi\u2010Nakamachi 874\u20100932 Beppu Oita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Cantor","sequence":"additional","affiliation":[{"name":"Scantibodies Laboratory Inc. 9336 Abraham Way, Santee California 92071 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Uchino","sequence":"additional","affiliation":[{"name":"Noguchi Thyroid Clinic and Hospital Foundation 6\u201033 Noguchi\u2010Nakamachi 874\u20100932 Beppu Oita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Noguchi Thyroid Clinic and Hospital Foundation 6\u201033 Noguchi\u2010Nakamachi 874\u20100932 Beppu Oita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Noguchi Thyroid Clinic and Hospital Foundation 6\u201033 Noguchi\u2010Nakamachi 874\u20100932 Beppu Oita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiki","family":"Moriyama","sequence":"additional","affiliation":[{"name":"Noguchi Thyroid Clinic and Hospital Foundation 6\u201033 Noguchi\u2010Nakamachi 874\u20100932 Beppu Oita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Takamatsu","sequence":"additional","affiliation":[{"name":"Noguchi Thyroid Clinic and Hospital Foundation 6\u201033 Noguchi\u2010Nakamachi 874\u20100932 Beppu Oita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Fukagawa","sequence":"additional","affiliation":[{"name":"Division of Dialysis and Metabolism Kobe University School of Medicine 7\u20105\u20102 Kusunoki\u2010cho 650\u20100017 Tyuou\u2010ku Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiro","family":"Noguchi","sequence":"additional","affiliation":[{"name":"Noguchi Thyroid Clinic and Hospital Foundation 6\u201033 Noguchi\u2010Nakamachi 874\u20100932 Beppu Oita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,1,20]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"70","article-title":"Long\u2010term results after surgical treatment of renal hyperparathyroidism when fewer than four glands are identified at operation","volume":"184","author":"Donckier V","year":"1997","journal-title":"J. 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