{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T22:59:33Z","timestamp":1783983573200,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,1,20]],"date-time":"2005-01-20T00:00:00Z","timestamp":1106179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2005,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The objective of this study was to assess the long\u2010term effects of adrenalectomy on the blood pressure and antihypertensive medication in patients with primary aldosteronism (PA). Twenty\u2010four patients (15 female and 9\u00a0male) with a mean age of 48.3 \u00b1 10.8 years underwent surgery for PA in our institution between 1988 and 2001. All subjects were re\u2010examined with a complete clinical work\u2010up after a mean follow\u2010up period of 86 \u00b1 48\u00a0months, including blood pressure readings (&lt;140\/90\u00a0mmHg defined as normal), endocrine adrenal function, and specific medication. All patients suffered from hypertension (onset 8.5 \u00b1 5.5 years prior to surgery). In 92% of the patients, hypokalemia was present (onset 2.0 \u00b1 2.6 years prior to surgery). The histopathologic examinations revealed unilateral adenomas in 23 patients and a bilateral hyperplasia in one patient. At follow\u2010up, 33% (8) of the patients were completely cured (normal blood pressure and no antihypertensive treatment), with seven of these eight patients being under 50 years of age at the time of surgery. One patient revealed a contralateral aldosterone\u2010secreting adrenal adenoma during the subsequent endocrine and imaging examination 44\u00a0months after the first operation. Despite normalized plasma\u2010aldosterone concentration (PAC), plasma\u2010renin\u2010activity (PRA) and serum potassium levels, a long\u2010lasting insufficiently treated hypertension due to the delayed diagnosis in patients with PA may explain the persistent blood pressure elevation, indicating the necessity of a life\u2010long, regular control of the blood pressure and antihypertensive medication.<\/jats:p>","DOI":"10.1007\/s00268-004-7496-z","type":"journal-article","created":{"date-parts":[[2005,1,13]],"date-time":"2005-01-13T08:51:31Z","timestamp":1105606291000},"page":"155-159","source":"Crossref","is-referenced-by-count":78,"title":["Long\u2010term Follow\u2010up after Adrenalectomy for Primary Aldosteronism"],"prefix":"10.1002","volume":"29","author":[{"given":"Andreas","family":"Meyer","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Viszeral\u2010 und Transplantationschirurgie, Medizinische Hochschule Hannover Carl\u2010Neuberg\u2010Str. 1 30625 Hannover Germany"},{"name":"Abt. f\u00fcr Strahlentherapie und spezielle Onkologie Medizinische Hochschule Hannover Carl\u2010Neuberg\u2010Str. 1 30625 Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Brabant","sequence":"additional","affiliation":[{"name":"Abt. f\u00fcr Gastroenterologie, Hepatologie und Endokrinologie Medizinische Hochschule Hannover Carl\u2010Neuberg\u2010Str. 1 30625 Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Behrend","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Viszeral\u2010 und Transplantationschirurgie, Medizinische Hochschule Hannover Carl\u2010Neuberg\u2010Str. 1 30625 Hannover Germany"},{"name":"Klinik f\u00fcr Viszeral\u2010, Thorax\u2010, Gefa\u03b2\u2010 und Kinderchirurgie Klinikum Deggendorf Perlasberger Str. 41 94469 Deggendorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,1,20]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"6","article-title":"Primary aldosteronism: a new clinical syndrome","volume":"45","author":"Conn JW","year":"1955","journal-title":"J. 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