{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T17:09:10Z","timestamp":1762016950157},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,1,18]],"date-time":"2005-01-18T00:00:00Z","timestamp":1106006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2005,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To reduce the chance of recurrent hyperthyroidism, two methods of subtotal thyroidectomy were performed and compared. From January 1998 to December 2002, 340 patients were operated on with subtotal thyroidectomy. They were prospectively randomized into two groups. Group A included 166 patients and group B 174 patients. Group A patients had a 2.5 \u00d7 1 \u00d7 1\u00a0cm thyroid remnant on each side and group B patients had a 2.5 \u00d71 \u00d7 1\u00a0cm remnant on one side plus total lobectomy on the other side. Thyroid function tests including T<jats:sub>3<\/jats:sub>, T<jats:sub>4<\/jats:sub>, TSH, and antimicrosomal antibody (AMA) were checked preoperatively and in the follow\u2010up period of 3\u00a0months, and later up to 26.4 \u00b1 1.1\u00a0months (mean \u00b1 SE). The age, sex, duration of oral medicine, and blood loss of the two groups were not significantly different during surgery and the follow\u2010up period. The operative time was less in group A (113 \u00b1 3.3\u00a0minutes) than that in group B (131 \u00b1 3.2\u00a0minutes) (<jats:italic>p<\/jats:italic> &lt; 0.001). In the long\u2010term follow\u2010up period, recurrent hyperthyroidism was noted in 15 patients in group A and 3 patients in group B. The difference was significant (<jats:italic>p<\/jats:italic> = 0.003). Hypothyroidism was noted in 35 of the group A patients and in 46 of the group B patients. The differences between the two groups regarding hypothyroidism was not significant (<jats:italic>p<\/jats:italic> = 0.181). Multivariate logistic regression analysis revealed preoperative titers of AMA \u2265 6400, which was the only factor affecting the incidence of hypothyroidism in the later follow\u2010up period. In consideration of hypothyroidism, recurrent hyperthyroidism, and postoperative complications, subtotal thyroidectomy with total lobectomy plus subtotal lobectomy provides a better outcome than bilateral subtotal lobectomy.<\/jats:p>","DOI":"10.1007\/s00268-004-7529-7","type":"journal-article","created":{"date-parts":[[2005,1,13]],"date-time":"2005-01-13T08:51:31Z","timestamp":1105606291000},"page":"160-163","source":"Crossref","is-referenced-by-count":34,"title":["A Prospective Randomized Comparison of Bilateral Subtotal Thyroidectomy Versus Unilateral Total and Contralateral Subtotal Thyroidectomy for Graves\u2019 Disease"],"prefix":"10.1002","volume":"29","author":[{"given":"Shun\u2010Yu","family":"Chi","sequence":"first","affiliation":[{"name":"Division of General Surgery, Department of Surgery Chang Gung Memorial Hospital at Kaohsioung 123 Ta Pei Road Niao\u2010Sung Hsiang Kaohsiung Hsien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun\u2010Chou","family":"Hsei","sequence":"additional","affiliation":[{"name":"Division of General Surgery, Department of Surgery Chang Gung Memorial Hospital at Kaohsioung 123 Ta Pei Road Niao\u2010Sung Hsiang Kaohsiung Hsien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shyr\u2010Ming","family":"Sheen\u2010Chen","sequence":"additional","affiliation":[{"name":"Division of General Surgery, Department of Surgery Chang Gung Memorial Hospital at Kaohsioung 123 Ta Pei Road Niao\u2010Sung Hsiang Kaohsiung Hsien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fong\u2010Fu","family":"Chou","sequence":"additional","affiliation":[{"name":"Division of General Surgery, Department of Surgery Chang Gung Memorial Hospital at Kaohsioung 123 Ta Pei Road Niao\u2010Sung Hsiang Kaohsiung Hsien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,1,18]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200010263431707"},{"key":"e_1_2_5_3_2","first-page":"1315","article-title":"Diagnosis and management of thyrotoxicosis","volume":"54","author":"Hennessey JV","year":"1996","journal-title":"Am. 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