{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,12,25]],"date-time":"2023-12-25T00:23:33Z","timestamp":1703463813538},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2004,11,11]],"date-time":"2004-11-11T00:00:00Z","timestamp":1100131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patients with primary hyperparathyroidism (pHPT) are sometimes treated with bisphosphonates (BPs) as an alternative to surgery despite sparse documentation of the efficacy in this disorder. It is therefore of interest to study the biochemical effects from BPs in patients with pHPT. A series of 21 pHPT patients with serum calcium levels &gt; 2.8\u00a0mmol\/L were included. One month before surgery the patients underwent intravenous infusions of 30 to 40\u00a0mg pamidronate. Study parameters were total and ionized serum calcium, intact parathormone (PTH), alkaline phosphatase (ALP) and isoenzymes, creatinine, osteocalcin, 25\u2010OH vitamin D<jats:sub>3<\/jats:sub>, 1,25\u2010OH<jats:sub>2<\/jats:sub> vitamin D<jats:sub>3<\/jats:sub>, urine calcium\/creatinine, and osmolality. Registration of hypercalcemia\u2010related symptoms were done by questionnaire. After pamidronate there was a temporary reduction in serum calcium with a nadir at 6 to 10\u00a0days. Normalization of serum calcium was achieved only by surgery. Intact PTH rose after pamidronate, with a maximum on day 6. Urinary calcium excretion was reduced after both pamidronate and surgery. ALP was reduced 30\u00a0days after pamidronate and also after surgery. Serum osteocalcin was not influenced by pamidronate. No statistically significant differences in symptoms were reported after treatment. In conclusion, there was a short, limited calcium\u2010lowering effect from pamidronate in pHPT patients and a transient increase in PTH corresponding to the reduced calcium concentration. An obvious change in bone markers was found only after surgery. Treatment with BPs should not be considered an alternative to surgery, which is still the only method to cure patients with pHPT.<\/jats:p>","DOI":"10.1007\/s00268-004-7611-1","type":"journal-article","created":{"date-parts":[[2004,11,5]],"date-time":"2004-11-05T17:17:42Z","timestamp":1099675062000},"page":"1293-1297","source":"Crossref","is-referenced-by-count":10,"title":["Biochemical Effects from Treatment with Bisphosphonate and Surgery in Patients with Primary Hyperparathyroidism"],"prefix":"10.1002","volume":"28","author":[{"given":"Svante","family":"Jansson","sequence":"first","affiliation":[{"name":"Department of Surgery Sahlgrenska University Hospital SE\u2010413 45 G\u00f6teborg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Morgan","sequence":"additional","affiliation":[{"name":"Department of Surgery Sahlgrenska University Hospital SE\u2010413 45 G\u00f6teborg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,11,11]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1976.tb08208.x"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039\u20106060(97)90357\u20103"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8529(18)30360-8"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002689910092"},{"key":"e_1_2_8_6_2","first-page":"N68","article-title":"Clinical presentation of primary hyperparathyroidism in Europe\u07ddnationwide cohort analysis on mortality from nonmalignant causes","volume":"17","author":"Nilsson IL","year":"2002","journal-title":"J. Bone Miner. Res."},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102362.1998.00289.x"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01658740"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V12suppl_1s3"},{"issue":"2","key":"e_1_2_8_10_2","first-page":"S1","volume":"6","author":"Potts JT","year":"1991","journal-title":"Bone Miner. Res."},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021370"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8529(05)70149-3"},{"key":"e_1_2_8_13_2","first-page":"N141","article-title":"Calcimimetics in the treatment of primary hyperparathyroidism","volume":"17","author":"Antoniucci DM","year":"2002","journal-title":"J. Bone Miner. Res."},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00041552\u2010200109000\u201000005"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523\u20101755.63.s85.22.x"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0690(02)00069-1"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7413.469"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1586\/14737140.3.2.241"},{"key":"e_1_2_8_19_2","first-page":"N57","article-title":"Asymptomatic primary hyperparathyroidism: new issues and new questions: bridging the past with the future","volume":"17","author":"Bilezikian JP","year":"2002","journal-title":"J. Bone Miner. Res."},{"key":"e_1_2_8_20_2","first-page":"N150","article-title":"Bisphosphonates and primary hyperparathyroidism","volume":"17","author":"Rodan GA","year":"2002","journal-title":"J. Bone Miner. Res."},{"key":"e_1_2_8_21_2","first-page":"N24","article-title":"The pathophysiology of primary hyperparathyroidism","volume":"17","author":"Brown EM","year":"2002","journal-title":"J. Bone Miner. Res."},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1053\/jarr.2002.34841"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1159\/000048935"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.3.5.521"},{"key":"e_1_2_8_25_2","first-page":"179","article-title":"Pathogenesis and management of cancer associated hypercalcaemia","volume":"21","author":"Ralston SH","year":"1994","journal-title":"Cancer Surv."},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(72)90173\u20100"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-125-5-199609010-00002"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.5.1901"},{"key":"e_1_2_8_29_2","first-page":"N154","article-title":"The basis for the post\u2010parathyroidectomy increase in bone mass","volume":"17","author":"Heaney RP","year":"2002","journal-title":"J. Bone Miner. Res."},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097\u20100142(20000615)88:12+<2961::AID\u2010CNCR12>3.3.CO;2\u2010C"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.2174\/1566524023362104"},{"key":"e_1_2_8_32_2","first-page":"N141","article-title":"Calcimimetics in the treatment of primary hyperparathyroidism","volume":"17","author":"Antoniucci DM","year":"2002","journal-title":"J. Bone Miner. Res."}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-004-7611-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-004-7611-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-004-7611-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,24]],"date-time":"2023-12-24T10:02:33Z","timestamp":1703412153000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-004-7611-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11,11]]},"references-count":31,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2004,12]]}},"alternative-id":["10.1007\/s00268-004-7611-1"],"URL":"https:\/\/doi.org\/10.1007\/s00268-004-7611-1","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,11,11]]}}}