{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:04:12Z","timestamp":1787497452395,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,3,23]],"date-time":"2005-03-23T00:00:00Z","timestamp":1111536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    In recent years considerable attention has been paid to the treatment of postoperative pain, with regard to the favorable effect of adequate analgesia on patient outcome. Multimodal analgesia (e.g., opioids and nonsteroidal anti\u2010inflammatory drugs [NSAIDs] or local anesthetics) is recommended for effective postoperative pain relief. There are few data on the use of NSAIDs in postoperative pain treatment after abdominal surgery. We conducted a randomized, double\u2010blind, placebo\u2010controlled study to assess the analgesic efficacy and safety of ketoprofen after major abdominal surgery. One and nine hours postoperatively patients received 100\u00a0mg of ketoprofen i.v. (\n                    <jats:italic>n<\/jats:italic>\n                    = 21) or placebo (\n                    <jats:italic>n<\/jats:italic>\n                    = 22) in addition to a pain\u2010treatment protocol consisting of continuous infusion of tramadol 200\u00a0mg and metamizol 5 g over 24 hours with additional 25\u00a0mg i.v. tramadol in case of inadequate analgesia. Pain was assessed by numeric rating scale at rest and at deep breath 3, 6, 12, and 24 hours postoperatively and the total dose of tramadol used in the first 24 hours was recorded. Patients in the ketoprofen group had significantly lower pain scores both at rest and at deep breath, at 3 (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.01), 6, and 12 hours (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05) postoperatively. The 24\u2010hour use of tramadol was significantly lower in the ketoprofen group (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.01), with less nausea and vomiting. There were no bleeding complications or other adverse events related to ketoprofen therapy. The study showed the value of short\u2010term use of ketoprofen to improve the quality of analgesia after major abdominal surgery without significant adverse effects.\n                  <\/jats:p>","DOI":"10.1007\/s00268-004-7612-0","type":"journal-article","created":{"date-parts":[[2005,3,16]],"date-time":"2005-03-16T15:39:53Z","timestamp":1110987593000},"page":"446-449","source":"Crossref","is-referenced-by-count":33,"title":["Intravenous Ketoprofen in Postoperative Pain Treatment after Major Abdominal Surgery"],"prefix":"10.1002","volume":"29","author":[{"given":"Dagmar","family":"Oberhofer","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Sveti Duh General Hospital Sveti Duh 64 10000 Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasna","family":"Skok","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Sveti Duh General Hospital Sveti Duh 64 10000 Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Visnja","family":"Nesek\u2010Adam","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Sveti Duh General Hospital Sveti Duh 64 10000 Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,3,23]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/87.1.62"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.3.11.1599"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199311000-00030"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0952\u20108180(01)00320\u20108"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/66.6.703"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1987.tb05317.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1987.tb05377.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/67.3.235"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199406000-00015"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(82)91089\u20103"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X0002800103"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X9402200105"},{"key":"e_1_2_5_14_2","first-page":"687","volume-title":"\u201cAnalgesic\u2010antipyretic and antiinflammatory agents and drugs employed in the treatment of gout\u201d","author":"Roberts LJ","year":"2001"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1191\/096813098668122984"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.311.7013.1145"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/85.2.217"},{"key":"e_1_2_5_18_2","first-page":"113","article-title":"Control of acute pain after major abdominal surgery in 585 patients given tramadol and ketorolac by intravenous infusion","volume":"28","author":"Pieri M","year":"2002","journal-title":"Drugs Exp. Clin. Res."}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-004-7612-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-004-7612-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-004-7612-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,24]],"date-time":"2023-12-24T06:38:03Z","timestamp":1703399883000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-004-7612-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3,23]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,4]]}},"alternative-id":["10.1007\/s00268-004-7612-0"],"URL":"https:\/\/doi.org\/10.1007\/s00268-004-7612-0","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,3,23]]}}}